Glutathione S-transferase M1, T1 and P1 polymorphisms and bladder cancer risk in Egyptians.

2.50
Hdl Handle:
http://hdl.handle.net/10541/74821
Title:
Glutathione S-transferase M1, T1 and P1 polymorphisms and bladder cancer risk in Egyptians.
Authors:
Saad, Abir A; O'Connor, Peter J; Mostafa, Mostafa H; Metwalli, Nabila E; Cooper, Donald P; Povey, Andrew C; Margison, Geoffrey P
Abstract:
Previous studies suggest that bladder cancer risk may vary with GST genotype but these results are inconsistent. The aim of this study was to explore whether GSTM1, GSTT1 and GSTP polymorphisms were associated with increased bladder cancer risk in an Egyptian population. GSTM1, GSTT1 and GSTP1 genotype frequencies were determined in bladder cancer cases (n=72) and healthy controls with no history of malignancies (n=82) using PCR-based techniques. The GSTT1*2 genotype was particularly associated with increased risk (OR 2.71, 95%CI 1.27-5.73) and the GSTM1*2 genotype to a lesser extent (OR 1.63, 95%CI 0.85-3.10). 18.1% of cases but only 7.3% of controls were GSTP1*B*B homozygotes (OR 2.38, 95%CI 0.83-6.87). The presence of two or more a priori at-risk genotypes was associated with increased bladder cancer risk (OR 2.42; 95%CI 1.47-3.97). These results suggest that polymorphisms in the GST genes are associated with increased risk of bladder cancer among Egyptians.
Affiliation:
Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom.
Citation:
Glutathione S-transferase M1, T1 and P1 polymorphisms and bladder cancer risk in Egyptians., 20 (1):69-72 Int. J. Biol. Markers
Journal:
The International Journal of Biological Markers
Issue Date:
2005
URI:
http://hdl.handle.net/10541/74821
PubMed ID:
15832776
Type:
Article
Language:
en
ISSN:
0393-6155
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorSaad, Abir A-
dc.contributor.authorO'Connor, Peter J-
dc.contributor.authorMostafa, Mostafa H-
dc.contributor.authorMetwalli, Nabila E-
dc.contributor.authorCooper, Donald P-
dc.contributor.authorPovey, Andrew C-
dc.contributor.authorMargison, Geoffrey P-
dc.date.accessioned2009-07-21T16:52:32Z-
dc.date.available2009-07-21T16:52:32Z-
dc.date.issued2005-
dc.identifier.citationGlutathione S-transferase M1, T1 and P1 polymorphisms and bladder cancer risk in Egyptians., 20 (1):69-72 Int. J. Biol. Markersen
dc.identifier.issn0393-6155-
dc.identifier.pmid15832776-
dc.identifier.urihttp://hdl.handle.net/10541/74821-
dc.description.abstractPrevious studies suggest that bladder cancer risk may vary with GST genotype but these results are inconsistent. The aim of this study was to explore whether GSTM1, GSTT1 and GSTP polymorphisms were associated with increased bladder cancer risk in an Egyptian population. GSTM1, GSTT1 and GSTP1 genotype frequencies were determined in bladder cancer cases (n=72) and healthy controls with no history of malignancies (n=82) using PCR-based techniques. The GSTT1*2 genotype was particularly associated with increased risk (OR 2.71, 95%CI 1.27-5.73) and the GSTM1*2 genotype to a lesser extent (OR 1.63, 95%CI 0.85-3.10). 18.1% of cases but only 7.3% of controls were GSTP1*B*B homozygotes (OR 2.38, 95%CI 0.83-6.87). The presence of two or more a priori at-risk genotypes was associated with increased bladder cancer risk (OR 2.42; 95%CI 1.47-3.97). These results suggest that polymorphisms in the GST genes are associated with increased risk of bladder cancer among Egyptians.en
dc.language.isoenen
dc.subjectUrinary Bladder Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshEgypt-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGlutathione S-Transferase pi-
dc.subject.meshGlutathione Transferase-
dc.subject.meshHumans-
dc.subject.meshIsoenzymes-
dc.subject.meshMiddle Aged-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshUrinary Bladder Neoplasms-
dc.titleGlutathione S-transferase M1, T1 and P1 polymorphisms and bladder cancer risk in Egyptians.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom.en
dc.identifier.journalThe International Journal of Biological Markersen

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