2.50
Hdl Handle:
http://hdl.handle.net/10541/74018
Title:
GSTM1 copy number and lung cancer risk.
Authors:
Crosbie, Philip A J; Barber, Philip V; Harrison, Kathryn L; Gibbs, Alan R; Agius, Raymond M; Margison, Geoffrey P; Povey, Andrew C
Abstract:
The GSTM1 null genotype is associated with a small increased lung cancer risk when compared to controls with at least one copy of the GSTM1 gene. As two copies of the GSTM1 gene might provide more protection than a single copy, we have determined GSTM1 copy number in a lung cancer case-control study. Cases with incident lung cancer were identified through a Bronchoscopy Unit and two separate hospital based control groups with non-malignant disease were selected with one from the same Bronchoscopy Unit and the other from a chest clinic at the same hospital. Subjects with at least one GSTM1 copy had a decreased lung cancer risk whatever the control group: the odds ratio (95% CI), after adjustment for age, gender and smoking duration, was 0.64 (0.41-0.98) and 0.54 (0.32-0.91) with bronchoscopy and chest clinic controls, respectively. Lung cancer risk varied with GSTM1 copy number with chest clinic controls only: the OR was 0.56 (0.32-0.97) for one copy of the GSTM1 gene and with two copies 0.43 (0.15-1.22), a trend that was significant (p=0.02): with bronchoscopy controls the trend was not significant (p=0.07). Results then confirm that the presence of GSTM1 provides protection against the risk of lung cancer. In addition there is equivocal evidence that this protection varies with the number of gene copies.
Affiliation:
Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom.
Citation:
GSTM1 copy number and lung cancer risk. 2009, 664 (1-2):1-5 Mutat. Res.
Journal:
Mutation Research
Issue Date:
12-May-2009
URI:
http://hdl.handle.net/10541/74018
DOI:
10.1016/j.mrfmmm.2009.01.006
PubMed ID:
19428374
Type:
Article
Language:
en
ISSN:
0027-5107
Appears in Collections:
All Paterson Institute for Cancer Research; Carcinogenesis Group

Full metadata record

DC FieldValue Language
dc.contributor.authorCrosbie, Philip A J-
dc.contributor.authorBarber, Philip V-
dc.contributor.authorHarrison, Kathryn L-
dc.contributor.authorGibbs, Alan R-
dc.contributor.authorAgius, Raymond M-
dc.contributor.authorMargison, Geoffrey P-
dc.contributor.authorPovey, Andrew C-
dc.date.accessioned2009-07-15T16:16:47Z-
dc.date.available2009-07-15T16:16:47Z-
dc.date.issued2009-05-12-
dc.identifier.citationGSTM1 copy number and lung cancer risk. 2009, 664 (1-2):1-5 Mutat. Res.en
dc.identifier.issn0027-5107-
dc.identifier.pmid19428374-
dc.identifier.doi10.1016/j.mrfmmm.2009.01.006-
dc.identifier.urihttp://hdl.handle.net/10541/74018-
dc.description.abstractThe GSTM1 null genotype is associated with a small increased lung cancer risk when compared to controls with at least one copy of the GSTM1 gene. As two copies of the GSTM1 gene might provide more protection than a single copy, we have determined GSTM1 copy number in a lung cancer case-control study. Cases with incident lung cancer were identified through a Bronchoscopy Unit and two separate hospital based control groups with non-malignant disease were selected with one from the same Bronchoscopy Unit and the other from a chest clinic at the same hospital. Subjects with at least one GSTM1 copy had a decreased lung cancer risk whatever the control group: the odds ratio (95% CI), after adjustment for age, gender and smoking duration, was 0.64 (0.41-0.98) and 0.54 (0.32-0.91) with bronchoscopy and chest clinic controls, respectively. Lung cancer risk varied with GSTM1 copy number with chest clinic controls only: the OR was 0.56 (0.32-0.97) for one copy of the GSTM1 gene and with two copies 0.43 (0.15-1.22), a trend that was significant (p=0.02): with bronchoscopy controls the trend was not significant (p=0.07). Results then confirm that the presence of GSTM1 provides protection against the risk of lung cancer. In addition there is equivocal evidence that this protection varies with the number of gene copies.en
dc.language.isoenen
dc.subjectLung Canceren
dc.subjectTobacco Smokeen
dc.subjectGSTM1en
dc.titleGSTM1 copy number and lung cancer risk.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom.en
dc.identifier.journalMutation Researchen

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