An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: an elevation of carbonic anhydrase activity.

2.50
Hdl Handle:
http://hdl.handle.net/10541/72953
Title:
An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: an elevation of carbonic anhydrase activity.
Authors:
Ozensoy, Ozen; Kockar, Feray; Arslan, Oktay; Isik, Semra; Supuran, Claudiu T; Lyon, Malcolm
Abstract:
OBJECTIVES: The antioxidant enzyme catalase and the CO2/HCO3- exchange enzyme carbonic anhydrase are both present in significant amounts in the cytosol of erythrocytes. The aim of the present study was to investigate whether these erythrocyte enzyme activities are altered in patients who have carcinoma. DESIGN AND METHODS: Cytosolic erythrocyte enzyme activities were measured in 108 cancer patients presenting with carcinoma at one of variable sites, prior to clinical treatment. These were compared with an age- and sex-matched control group of 31 healthy volunteers. RESULTS: Mean (+/-SD) catalase activities did not differ significantly, i.e. 0.0035 (+/-0.0015) EU/ml in carcinoma patients vs. 0.0031 (+/-0.00075) EU/ml in controls. However, mean carbonic anhydrase activities of 204 (+/-91) EU/ml in the carcinoma patients were significantly higher than the 158 (+/-35) EU/ml in controls (P value of 0.0065). CONCLUSION: Cytosolic erythrocyte carbonic anhydrase levels may warrant further investigation as a potential peripheral marker in cancer.
Affiliation:
Balikesir University Faculty of Science and Literature, Department of Chemistry, Soma Street, 10100 Balikesir, Turkey. ozensoy@balikesir.edu.tr
Citation:
An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: an elevation of carbonic anhydrase activity. 2006, 39 (8):804-9 Clin. Biochem.
Journal:
Clinical Biochemistry
Issue Date:
Aug-2006
URI:
http://hdl.handle.net/10541/72953
DOI:
10.1016/j.clinbiochem.2006.03.001
PubMed ID:
16624271
Type:
Article
Language:
en
ISSN:
0009-9120
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorOzensoy, Ozen-
dc.contributor.authorKockar, Feray-
dc.contributor.authorArslan, Oktay-
dc.contributor.authorIsik, Semra-
dc.contributor.authorSupuran, Claudiu T-
dc.contributor.authorLyon, Malcolm-
dc.date.accessioned2009-07-08T09:14:35Z-
dc.date.available2009-07-08T09:14:35Z-
dc.date.issued2006-08-
dc.identifier.citationAn evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: an elevation of carbonic anhydrase activity. 2006, 39 (8):804-9 Clin. Biochem.en
dc.identifier.issn0009-9120-
dc.identifier.pmid16624271-
dc.identifier.doi10.1016/j.clinbiochem.2006.03.001-
dc.identifier.urihttp://hdl.handle.net/10541/72953-
dc.description.abstractOBJECTIVES: The antioxidant enzyme catalase and the CO2/HCO3- exchange enzyme carbonic anhydrase are both present in significant amounts in the cytosol of erythrocytes. The aim of the present study was to investigate whether these erythrocyte enzyme activities are altered in patients who have carcinoma. DESIGN AND METHODS: Cytosolic erythrocyte enzyme activities were measured in 108 cancer patients presenting with carcinoma at one of variable sites, prior to clinical treatment. These were compared with an age- and sex-matched control group of 31 healthy volunteers. RESULTS: Mean (+/-SD) catalase activities did not differ significantly, i.e. 0.0035 (+/-0.0015) EU/ml in carcinoma patients vs. 0.0031 (+/-0.00075) EU/ml in controls. However, mean carbonic anhydrase activities of 204 (+/-91) EU/ml in the carcinoma patients were significantly higher than the 158 (+/-35) EU/ml in controls (P value of 0.0065). CONCLUSION: Cytosolic erythrocyte carbonic anhydrase levels may warrant further investigation as a potential peripheral marker in cancer.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAdult-
dc.subject.meshCarbonic Anhydrases-
dc.subject.meshCase-Control Studies-
dc.subject.meshCatalase-
dc.subject.meshCytosol-
dc.subject.meshErythrocytes-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshNeoplasms-
dc.titleAn evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: an elevation of carbonic anhydrase activity.en
dc.typeArticleen
dc.contributor.departmentBalikesir University Faculty of Science and Literature, Department of Chemistry, Soma Street, 10100 Balikesir, Turkey. ozensoy@balikesir.edu.tren
dc.identifier.journalClinical Biochemistryen

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