2.50
Hdl Handle:
http://hdl.handle.net/10541/72861
Title:
Imaging vascular physiology to monitor cancer treatment.
Authors:
Laking, George R; West, Catharine M L; Buckley, David L; Matthews, Julian C; Price, Patricia M
Abstract:
The primary physiological function of the vasculature is to support perfusion, the nutritive flow of blood through the tissues. Vascular physiology can be studied non-invasively in human subjects using imaging methods such as positron emission tomography (PET), magnetic resonance imaging (MRI), X-ray computed tomography (CT), and Doppler ultrasound (DU). We describe the physiological rationale for imaging vascular physiology with these methods. We review the published data on repeatability. We review the literature on 'before-and-after' studies using these methods to monitor response to treatment in human subjects, in five broad clinical settings: (1) antiangiogenic agents, (2) vascular disruptive agents, (3) conventional cytotoxic drugs, (4) radiation treatment, and (5) agents affecting drug delivery. We argue that imaging of vascular physiology offers an attractive 'functional endpoint' for clinical trials of anticancer treatment. More conventional measures of tumour response, such as size criteria and the uptake of fluorodeoxyglucose, may be insensitive to therapeutically important changes in vascular function.
Affiliation:
Cancer Research UK PET Oncology Group, University of Manchester, Wolfson Molecular Imaging Centre, Manchester M203LJ, UK. george.laking@manchester.ac.uk
Citation:
Imaging vascular physiology to monitor cancer treatment. 2006, 58 (2):95-113 Crit. Rev. Oncol. Hematol.
Journal:
Critical Reviews in Oncology/Hematology
Issue Date:
May-2006
URI:
http://hdl.handle.net/10541/72861
DOI:
10.1016/j.critrevonc.2005.10.006
PubMed ID:
16387510
Type:
Article
Language:
en
ISSN:
1040-8428
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLaking, George R-
dc.contributor.authorWest, Catharine M L-
dc.contributor.authorBuckley, David L-
dc.contributor.authorMatthews, Julian C-
dc.contributor.authorPrice, Patricia M-
dc.date.accessioned2009-07-07T15:42:04Z-
dc.date.available2009-07-07T15:42:04Z-
dc.date.issued2006-05-
dc.identifier.citationImaging vascular physiology to monitor cancer treatment. 2006, 58 (2):95-113 Crit. Rev. Oncol. Hematol.en
dc.identifier.issn1040-8428-
dc.identifier.pmid16387510-
dc.identifier.doi10.1016/j.critrevonc.2005.10.006-
dc.identifier.urihttp://hdl.handle.net/10541/72861-
dc.description.abstractThe primary physiological function of the vasculature is to support perfusion, the nutritive flow of blood through the tissues. Vascular physiology can be studied non-invasively in human subjects using imaging methods such as positron emission tomography (PET), magnetic resonance imaging (MRI), X-ray computed tomography (CT), and Doppler ultrasound (DU). We describe the physiological rationale for imaging vascular physiology with these methods. We review the published data on repeatability. We review the literature on 'before-and-after' studies using these methods to monitor response to treatment in human subjects, in five broad clinical settings: (1) antiangiogenic agents, (2) vascular disruptive agents, (3) conventional cytotoxic drugs, (4) radiation treatment, and (5) agents affecting drug delivery. We argue that imaging of vascular physiology offers an attractive 'functional endpoint' for clinical trials of anticancer treatment. More conventional measures of tumour response, such as size criteria and the uptake of fluorodeoxyglucose, may be insensitive to therapeutically important changes in vascular function.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAngiogenesis Inhibitors-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshBlood Flow Velocity-
dc.subject.meshClinical Trials as Topic-
dc.subject.meshDiagnostic Imaging-
dc.subject.meshDrug Monitoring-
dc.subject.meshHumans-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMonitoring, Physiologic-
dc.subject.meshNeoplasms-
dc.subject.meshNeovascularization, Pathologic-
dc.subject.meshPositron-Emission Tomography-
dc.subject.meshReproducibility of Results-
dc.subject.meshUltrasonography, Doppler-
dc.titleImaging vascular physiology to monitor cancer treatment.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK PET Oncology Group, University of Manchester, Wolfson Molecular Imaging Centre, Manchester M203LJ, UK. george.laking@manchester.ac.uken
dc.identifier.journalCritical Reviews in Oncology/Hematologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.