Affiliation
Cancer Research UK PET Oncology Group, University of Manchester, Wolfson Molecular Imaging Centre, Manchester M203LJ, UK. george.laking@manchester.ac.ukIssue Date
2006-05
Metadata
Show full item recordAbstract
The primary physiological function of the vasculature is to support perfusion, the nutritive flow of blood through the tissues. Vascular physiology can be studied non-invasively in human subjects using imaging methods such as positron emission tomography (PET), magnetic resonance imaging (MRI), X-ray computed tomography (CT), and Doppler ultrasound (DU). We describe the physiological rationale for imaging vascular physiology with these methods. We review the published data on repeatability. We review the literature on 'before-and-after' studies using these methods to monitor response to treatment in human subjects, in five broad clinical settings: (1) antiangiogenic agents, (2) vascular disruptive agents, (3) conventional cytotoxic drugs, (4) radiation treatment, and (5) agents affecting drug delivery. We argue that imaging of vascular physiology offers an attractive 'functional endpoint' for clinical trials of anticancer treatment. More conventional measures of tumour response, such as size criteria and the uptake of fluorodeoxyglucose, may be insensitive to therapeutically important changes in vascular function.Citation
Imaging vascular physiology to monitor cancer treatment. 2006, 58 (2):95-113 Crit. Rev. Oncol. Hematol.Journal
Critical Reviews in Oncology/HematologyDOI
10.1016/j.critrevonc.2005.10.006PubMed ID
16387510Type
ArticleLanguage
enISSN
1040-8428ae974a485f413a2113503eed53cd6c53
10.1016/j.critrevonc.2005.10.006
Scopus Count
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