2.50
Hdl Handle:
http://hdl.handle.net/10541/72840
Title:
Hypoxia in head and neck cancer.
Authors:
Isa, Aidah Y; Ward, Timothy H; West, Catharine M L; Slevin, Nicholas J ( 0000-0002-3367-7013 ) ; Homer, Jarrod J
Abstract:
A high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the status of research into finding a practical method for measuring hypoxia and treating hypoxic tumours. The application of such methodology would enable the selection of head and neck cancer treatment based on an individual's tumour oxygenation status. This individualization would include the selection not only of surgery or radiotherapy, but also of novel hypoxia-modification strategies.
Affiliation:
Department of Surgery, Christie Hospital, Manchester, UK.
Citation:
Hypoxia in head and neck cancer. 2006, 79 (946):791-8 Br J Radiol
Journal:
The British Journal of Radiology
Issue Date:
Oct-2006
URI:
http://hdl.handle.net/10541/72840
DOI:
10.1259/bjr/17904358
PubMed ID:
16854964
Type:
Article
Language:
en
ISSN:
1748-880X
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorIsa, Aidah Y-
dc.contributor.authorWard, Timothy H-
dc.contributor.authorWest, Catharine M L-
dc.contributor.authorSlevin, Nicholas J-
dc.contributor.authorHomer, Jarrod J-
dc.date.accessioned2009-07-07T15:58:45Z-
dc.date.available2009-07-07T15:58:45Z-
dc.date.issued2006-10-
dc.identifier.citationHypoxia in head and neck cancer. 2006, 79 (946):791-8 Br J Radiolen
dc.identifier.issn1748-880X-
dc.identifier.pmid16854964-
dc.identifier.doi10.1259/bjr/17904358-
dc.identifier.urihttp://hdl.handle.net/10541/72840-
dc.description.abstractA high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the status of research into finding a practical method for measuring hypoxia and treating hypoxic tumours. The application of such methodology would enable the selection of head and neck cancer treatment based on an individual's tumour oxygenation status. This individualization would include the selection not only of surgery or radiotherapy, but also of novel hypoxia-modification strategies.en
dc.language.isoenen
dc.subjectHaemoglobinsen
dc.subjectHead and Neck Canceren
dc.subject.meshAntibiotics, Antineoplastic-
dc.subject.meshBasic Helix-Loop-Helix Transcription Factors-
dc.subject.meshBiological Markers-
dc.subject.meshCell Hypoxia-
dc.subject.meshComet Assay-
dc.subject.meshHead and Neck Neoplasms-
dc.subject.meshHemoglobins-
dc.subject.meshHumans-
dc.subject.meshHypoxia-Inducible Factor 1, alpha Subunit-
dc.subject.meshMicroelectrodes-
dc.subject.meshNitroimidazoles-
dc.subject.meshOxygen-
dc.subject.meshPositron-Emission Tomography-
dc.subject.meshPrognosis-
dc.subject.meshRadiation-Sensitizing Agents-
dc.titleHypoxia in head and neck cancer.en
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, Christie Hospital, Manchester, UK.en
dc.identifier.journalThe British Journal of Radiologyen

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