The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study.

2.50
Hdl Handle:
http://hdl.handle.net/10541/72836
Title:
The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study.
Authors:
Nordsmark, Marianne; Loncaster, Juliette A; Aquino-Parsons, Christina; Chou, Shu-Chuan; Gebski, Val; West, Catharine M L; Lindegaard, Jacob C; Havsteen, Hanne; Davidson, Susan E; Hunter, Robin D; Raleigh, James A; Overgaard, Jens
Abstract:
BACKGROUND AND PURPOSE: Hypoxia adversely affects treatment outcome in human uterine cervical cancer. Here, we present the results of a prospective international multi-centre study evaluating the prognostic value of pre-treatment tumour oxygen partial pressure (pO(2)) and the hypoxia marker pimonidazole (pimo). MATERIALS AND METHODS: One hundred and twenty-seven patients with primary cervix cancer were entered. Pre-treatment tumour pO(2) measurements were obtained, and reported by the median tumour pO(2), the fraction of pO(2) values <or=10 mmHg (HP(10)), <or=5 mmHg (HP(5)) and <or=2.5 mmHg (HP(2.5)). Following intravenous pimonidazole administration, biopsies were taken, stained for pimonidazole adducts, and scored for the area of labelled tumour cells on a scale from 0 to 4. Treatment modalities were surgery (11%), radiotherapy (98%), chemotherapy (33%) and carbogen (14%). RESULTS: None of the hypoxia descriptors were statistically significant prognostic factors for loco-regional tumour control or overall survival when analyzed as continuous variables or divided by the sample median. By univariate analysis only tumour size and nodal status were significant prognostic factors for local control. Tumour size and FIGO stage were significant for overall survival. In a multivariate analysis stratified by centre, only tumour size above 5 cm and lower pre-treatment haemoglobin predicted poorer overall survival among FIGO stage, nodal involvement, tumour size, pre-treatment haemoglobin dichotomized at 12 g/dl and pimo 1, pimo 4 and HP(5) as continuous variables. CONCLUSION: Neither Eppendorf nor pimonidazole should be dismissed based on the current results. However, further investigations are needed to readdress the hypotheses of the current study having optimized statistical designs, and a population of sufficient size treated more homogenously following rigorous protocols.
Affiliation:
Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark. marianne@oncology.dk <marianne@oncology.dk>
Citation:
The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study. 2006, 80 (2):123-31 Radiother Oncol
Journal:
Radiotherapy and Oncology
Issue Date:
Aug-2006
URI:
http://hdl.handle.net/10541/72836
DOI:
10.1016/j.radonc.2006.07.010
PubMed ID:
16890316
Type:
Article
Language:
en
ISSN:
0167-8140
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorNordsmark, Marianne-
dc.contributor.authorLoncaster, Juliette A-
dc.contributor.authorAquino-Parsons, Christina-
dc.contributor.authorChou, Shu-Chuan-
dc.contributor.authorGebski, Val-
dc.contributor.authorWest, Catharine M L-
dc.contributor.authorLindegaard, Jacob C-
dc.contributor.authorHavsteen, Hanne-
dc.contributor.authorDavidson, Susan E-
dc.contributor.authorHunter, Robin D-
dc.contributor.authorRaleigh, James A-
dc.contributor.authorOvergaard, Jens-
dc.date.accessioned2009-07-07T15:22:05Z-
dc.date.available2009-07-07T15:22:05Z-
dc.date.issued2006-08-
dc.identifier.citationThe prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study. 2006, 80 (2):123-31 Radiother Oncolen
dc.identifier.issn0167-8140-
dc.identifier.pmid16890316-
dc.identifier.doi10.1016/j.radonc.2006.07.010-
dc.identifier.urihttp://hdl.handle.net/10541/72836-
dc.description.abstractBACKGROUND AND PURPOSE: Hypoxia adversely affects treatment outcome in human uterine cervical cancer. Here, we present the results of a prospective international multi-centre study evaluating the prognostic value of pre-treatment tumour oxygen partial pressure (pO(2)) and the hypoxia marker pimonidazole (pimo). MATERIALS AND METHODS: One hundred and twenty-seven patients with primary cervix cancer were entered. Pre-treatment tumour pO(2) measurements were obtained, and reported by the median tumour pO(2), the fraction of pO(2) values <or=10 mmHg (HP(10)), <or=5 mmHg (HP(5)) and <or=2.5 mmHg (HP(2.5)). Following intravenous pimonidazole administration, biopsies were taken, stained for pimonidazole adducts, and scored for the area of labelled tumour cells on a scale from 0 to 4. Treatment modalities were surgery (11%), radiotherapy (98%), chemotherapy (33%) and carbogen (14%). RESULTS: None of the hypoxia descriptors were statistically significant prognostic factors for loco-regional tumour control or overall survival when analyzed as continuous variables or divided by the sample median. By univariate analysis only tumour size and nodal status were significant prognostic factors for local control. Tumour size and FIGO stage were significant for overall survival. In a multivariate analysis stratified by centre, only tumour size above 5 cm and lower pre-treatment haemoglobin predicted poorer overall survival among FIGO stage, nodal involvement, tumour size, pre-treatment haemoglobin dichotomized at 12 g/dl and pimo 1, pimo 4 and HP(5) as continuous variables. CONCLUSION: Neither Eppendorf nor pimonidazole should be dismissed based on the current results. However, further investigations are needed to readdress the hypotheses of the current study having optimized statistical designs, and a population of sufficient size treated more homogenously following rigorous protocols.en
dc.language.isoenen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshCell Hypoxia-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshNitroimidazoles-
dc.subject.meshOxygen-
dc.subject.meshPartial Pressure-
dc.subject.meshPrognosis-
dc.subject.meshProspective Studies-
dc.subject.meshRadiation-Sensitizing Agents-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleThe prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Clinical Oncology, Aarhus University Hospital, Denmark. marianne@oncology.dk <marianne@oncology.dk>en
dc.identifier.journalRadiotherapy and Oncologyen

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