2.50
Hdl Handle:
http://hdl.handle.net/10541/72747
Title:
Breast stem cells and cancer.
Authors:
Farnie, Gillian; Clarke, Robert B
Abstract:
Recent results have increased our understanding of normal stem cells and the signalling pathways which regulate them during the development of the mammary gland. Tumours in many tissues are now thought to develop from dysregulated stem cells and depend on activated stem cell self-renewal pathways such as Notch for their tumourigenic capacity. These cancer stem cells are recognised by specific cell surface proteins that they express and their capacity to grow tumours in vivo or spheres in vitro. We have described human breast DCIS mammospheres grown from cancer stem cells and demonstrated their dependence on the EGF and Notch receptor pathways. Stem cell self-renewal pathways such as these may represent novel therapeutic targets to prevent recurrence of pre-invasive and invasive breast cancer.
Affiliation:
Breast Biology Group, School of Cancer and Imaging Sciences, Faculty of Medicine and Human Sciences, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX Manchester, UK.
Citation:
Breast stem cells and cancer. 2006 (5):141-53 Ernst Schering Found Symp Proc
Journal:
Ernst Schering Foundation Symposium Proceedings
Issue Date:
2006
URI:
http://hdl.handle.net/10541/72747
DOI:
10.1007/2789_2007_049
PubMed ID:
17939300
Type:
Article
Language:
en
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorFarnie, Gillian-
dc.contributor.authorClarke, Robert B-
dc.date.accessioned2009-07-07T11:59:47Z-
dc.date.available2009-07-07T11:59:47Z-
dc.date.issued2006-
dc.identifier.citationBreast stem cells and cancer. 2006 (5):141-53 Ernst Schering Found Symp Procen
dc.identifier.pmid17939300-
dc.identifier.doi10.1007/2789_2007_049-
dc.identifier.urihttp://hdl.handle.net/10541/72747-
dc.description.abstractRecent results have increased our understanding of normal stem cells and the signalling pathways which regulate them during the development of the mammary gland. Tumours in many tissues are now thought to develop from dysregulated stem cells and depend on activated stem cell self-renewal pathways such as Notch for their tumourigenic capacity. These cancer stem cells are recognised by specific cell surface proteins that they express and their capacity to grow tumours in vivo or spheres in vitro. We have described human breast DCIS mammospheres grown from cancer stem cells and demonstrated their dependence on the EGF and Notch receptor pathways. Stem cell self-renewal pathways such as these may represent novel therapeutic targets to prevent recurrence of pre-invasive and invasive breast cancer.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshBreast-
dc.subject.meshBreast Neoplasms-
dc.subject.meshEpidermal Growth Factor-
dc.subject.meshHumans-
dc.subject.meshReceptors, Notch-
dc.subject.meshSignal Transduction-
dc.subject.meshStem Cells-
dc.titleBreast stem cells and cancer.en
dc.typeArticleen
dc.contributor.departmentBreast Biology Group, School of Cancer and Imaging Sciences, Faculty of Medicine and Human Sciences, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX Manchester, UK.en
dc.identifier.journalErnst Schering Foundation Symposium Proceedingsen

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