High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?

2.50
Hdl Handle:
http://hdl.handle.net/10541/72739
Title:
High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?
Authors:
Sims, Andrew H; Ong, Kai Ren; Clarke, Robert B; Howell, Anthony ( 0000-0002-3879-5991 )
Abstract:
Gene expression profiling is a relatively new technology for the study of breast cancers, but within the past few years there has been a rapid rise in interest in its potential to improve the clinical management of breast cancer. This technology has contributed to our knowledge of the molecular pathology of breast tumours and shows promise as a tool to predict response to therapy and outcome, such as risk of metastasis. Microarray technology is continually developing and it is becoming apparent that, despite the various platforms available, robust conclusions can still be drawn that apply across the different array types. Gene expression profiling is beginning to appear in the breast cancer clinic but it is not yet fully evaluated. This review explores the questions that must be addressed before this technology can become an everyday clinical tool.
Affiliation:
Breast Biology Group, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK.
Citation:
High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic? 2006, 8 (5):214 Breast Cancer Res.
Journal:
Breast Cancer Research
Issue Date:
2006
URI:
http://hdl.handle.net/10541/72739
DOI:
10.1186/bcr1605
PubMed ID:
17076877
Type:
Article
Language:
en
ISSN:
1465-542X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorSims, Andrew H-
dc.contributor.authorOng, Kai Ren-
dc.contributor.authorClarke, Robert B-
dc.contributor.authorHowell, Anthony-
dc.date.accessioned2009-07-07T11:22:35Z-
dc.date.available2009-07-07T11:22:35Z-
dc.date.issued2006-
dc.identifier.citationHigh-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic? 2006, 8 (5):214 Breast Cancer Res.en
dc.identifier.issn1465-542X-
dc.identifier.pmid17076877-
dc.identifier.doi10.1186/bcr1605-
dc.identifier.urihttp://hdl.handle.net/10541/72739-
dc.description.abstractGene expression profiling is a relatively new technology for the study of breast cancers, but within the past few years there has been a rapid rise in interest in its potential to improve the clinical management of breast cancer. This technology has contributed to our knowledge of the molecular pathology of breast tumours and shows promise as a tool to predict response to therapy and outcome, such as risk of metastasis. Microarray technology is continually developing and it is becoming apparent that, despite the various platforms available, robust conclusions can still be drawn that apply across the different array types. Gene expression profiling is beginning to appear in the breast cancer clinic but it is not yet fully evaluated. This review explores the questions that must be addressed before this technology can become an everyday clinical tool.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshBreast Neoplasms-
dc.subject.meshClinical Trials as Topic-
dc.subject.meshCost-Benefit Analysis-
dc.subject.meshFemale-
dc.subject.meshGene Expression Profiling-
dc.subject.meshHumans-
dc.subject.meshOligonucleotide Array Sequence Analysis-
dc.subject.meshPrognosis-
dc.subject.meshTechnology Transfer-
dc.titleHigh-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?en
dc.typeArticleen
dc.contributor.departmentBreast Biology Group, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK.en
dc.identifier.journalBreast Cancer Researchen

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