Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: A pooled analysis of three clinical trials.

2.50
Hdl Handle:
http://hdl.handle.net/10541/72734
Title:
Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: A pooled analysis of three clinical trials.
Authors:
Trumper, M; Ross, P J; Cunningham, David; Norman, A; Hawkins, Robert E; Seymour, M T; Harper, P; Iveson, T; Nicolson, M; Hickish, T
Abstract:
The aim of this study was to determine the benefits of chemotherapy for oesophago-gastric cancer (OGC) in patients 70 years and above (> or =70) in comparison to younger patients. 1080 patients were enrolled into three randomised controlled trials assessing fluorouracil-based combination chemotherapy. Patients received either a platinum-containing regimen (ECF, MCF), PVI 5-FU (protracted venous infusion of 5-fluorouracil)+/-mitomycin C (MMC), or FAMTX. Of the 1080 patients randomised, 257 (23.8%) were aged > or =70 years. There were no significant differences in the incidence of grades 3/4 toxicity between the two cohorts. Objective and symptomatic response rates, failure-free and overall survival were not significantly different. In a multivariate analysis, independent prognostic factors for survival were performance status and locally advanced disease, not age. Patients > or =70 years with OGC obtained similar benefits from palliative chemotherapy with respect to symptomatic response, tumour regression and survival, without increased toxicities.
Affiliation:
Section of Medicine, Gastrointestinal Unit, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, United Kingdom.
Citation:
Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: A pooled analysis of three clinical trials. 2006, 42 (7):827-34 Eur. J. Cancer
Journal:
European Journal of Cancer
Issue Date:
May-2006
URI:
http://hdl.handle.net/10541/72734
DOI:
10.1016/j.ejca.2005.08.044
PubMed ID:
16466913
Type:
Article
Language:
en
ISSN:
0959-8049
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorTrumper, M-
dc.contributor.authorRoss, P J-
dc.contributor.authorCunningham, David-
dc.contributor.authorNorman, A-
dc.contributor.authorHawkins, Robert E-
dc.contributor.authorSeymour, M T-
dc.contributor.authorHarper, P-
dc.contributor.authorIveson, T-
dc.contributor.authorNicolson, M-
dc.contributor.authorHickish, T-
dc.date.accessioned2009-07-07T11:10:55Z-
dc.date.available2009-07-07T11:10:55Z-
dc.date.issued2006-05-
dc.identifier.citationEfficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: A pooled analysis of three clinical trials. 2006, 42 (7):827-34 Eur. J. Canceren
dc.identifier.issn0959-8049-
dc.identifier.pmid16466913-
dc.identifier.doi10.1016/j.ejca.2005.08.044-
dc.identifier.urihttp://hdl.handle.net/10541/72734-
dc.description.abstractThe aim of this study was to determine the benefits of chemotherapy for oesophago-gastric cancer (OGC) in patients 70 years and above (> or =70) in comparison to younger patients. 1080 patients were enrolled into three randomised controlled trials assessing fluorouracil-based combination chemotherapy. Patients received either a platinum-containing regimen (ECF, MCF), PVI 5-FU (protracted venous infusion of 5-fluorouracil)+/-mitomycin C (MMC), or FAMTX. Of the 1080 patients randomised, 257 (23.8%) were aged > or =70 years. There were no significant differences in the incidence of grades 3/4 toxicity between the two cohorts. Objective and symptomatic response rates, failure-free and overall survival were not significantly different. In a multivariate analysis, independent prognostic factors for survival were performance status and locally advanced disease, not age. Patients > or =70 years with OGC obtained similar benefits from palliative chemotherapy with respect to symptomatic response, tumour regression and survival, without increased toxicities.en
dc.language.isoenen
dc.subjectOesophageal Canceren
dc.subjectStomach Canceren
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshDisease-Free Survival-
dc.subject.meshEsophageal Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshRandomized Controlled Trials as Topic-
dc.subject.meshStomach Neoplasms-
dc.subject.meshTreatment Outcome-
dc.titleEfficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: A pooled analysis of three clinical trials.en
dc.typeArticleen
dc.contributor.departmentSection of Medicine, Gastrointestinal Unit, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, United Kingdom.en
dc.identifier.journalEuropean Journal of Canceren

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