Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI.

2.50
Hdl Handle:
http://hdl.handle.net/10541/72716
Title:
Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI.
Authors:
Parker, Geoff J M; Roberts, Caleb; Macdonald, Andrew; Buonaccorsi, Giovanni A; Cheung, Susan; Buckley, David L; Jackson, Alan; Watson, Yvonne; Davies, Karen; Jayson, Gordon C ( 0000-0002-8515-8944 )
Abstract:
Rapid T(1)-weighted 3D spoiled gradient-echo (GRE) data sets were acquired in the abdomen of 23 cancer patients during a total of 113 separate visits to allow dynamic contrast-enhanced MRI (DCE-MRI) analysis of tumor microvasculature. The arterial input function (AIF) was measured in each patient at each visit using an automated AIF extraction method following a standardized bolus administration of gadodiamide. The AIFs for each patient were combined to obtain a mean AIF that is representative for any individual. The functional form of this general AIF may be useful for studies in which AIF measurements are not possible. Improvements in the reproducibility of DCE-MRI model parameters (K(trans), v(e), and v(p)) were observed when this new, high-temporal-resolution population AIF was used, indicating the potential for increased sensitivity to therapy-induced change.
Affiliation:
Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK. geoff.parker@manchester.ac.uk
Citation:
Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI. 2006, 56 (5):993-1000 Magn Reson Med
Journal:
Magnetic Resonance in Medicine
Issue Date:
Nov-2006
URI:
http://hdl.handle.net/10541/72716
DOI:
10.1002/mrm.21066
PubMed ID:
17036301
Type:
Article
Language:
en
ISSN:
0740-3194
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorParker, Geoff J M-
dc.contributor.authorRoberts, Caleb-
dc.contributor.authorMacdonald, Andrew-
dc.contributor.authorBuonaccorsi, Giovanni A-
dc.contributor.authorCheung, Susan-
dc.contributor.authorBuckley, David L-
dc.contributor.authorJackson, Alan-
dc.contributor.authorWatson, Yvonne-
dc.contributor.authorDavies, Karen-
dc.contributor.authorJayson, Gordon C-
dc.date.accessioned2009-07-07T10:42:43Z-
dc.date.available2009-07-07T10:42:43Z-
dc.date.issued2006-11-
dc.identifier.citationExperimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI. 2006, 56 (5):993-1000 Magn Reson Meden
dc.identifier.issn0740-3194-
dc.identifier.pmid17036301-
dc.identifier.doi10.1002/mrm.21066-
dc.identifier.urihttp://hdl.handle.net/10541/72716-
dc.description.abstractRapid T(1)-weighted 3D spoiled gradient-echo (GRE) data sets were acquired in the abdomen of 23 cancer patients during a total of 113 separate visits to allow dynamic contrast-enhanced MRI (DCE-MRI) analysis of tumor microvasculature. The arterial input function (AIF) was measured in each patient at each visit using an automated AIF extraction method following a standardized bolus administration of gadodiamide. The AIFs for each patient were combined to obtain a mean AIF that is representative for any individual. The functional form of this general AIF may be useful for studies in which AIF measurements are not possible. Improvements in the reproducibility of DCE-MRI model parameters (K(trans), v(e), and v(p)) were observed when this new, high-temporal-resolution population AIF was used, indicating the potential for increased sensitivity to therapy-induced change.en
dc.language.isoenen
dc.subjectAbdominal Canceren
dc.subjectPelvic Canceren
dc.subject.meshAbdominal Neoplasms-
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAlgorithms-
dc.subject.meshArteries-
dc.subject.meshComputer Simulation-
dc.subject.meshContrast Media-
dc.subject.meshEcho-Planar Imaging-
dc.subject.meshFemale-
dc.subject.meshGadolinium DTPA-
dc.subject.meshHumans-
dc.subject.meshImage Enhancement-
dc.subject.meshImage Interpretation, Computer-Assisted-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshModels, Biological-
dc.subject.meshModels, Statistical-
dc.subject.meshPelvic Neoplasms-
dc.subject.meshReproducibility of Results-
dc.subject.meshSensitivity and Specificity-
dc.titleExperimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI.en
dc.typeArticleen
dc.contributor.departmentImaging Science and Biomedical Engineering, University of Manchester, Manchester, UK. geoff.parker@manchester.ac.uken
dc.identifier.journalMagnetic Resonance in Medicineen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.