2.50
Hdl Handle:
http://hdl.handle.net/10541/72713
Title:
Human breast epithelial stem cells and their regulation.
Authors:
Kalirai, Helen; Clarke, Robert B
Abstract:
This review summarizes the current evidence for the existence of human breast stem cells and the pathways involved in their regulation, and discusses how the disruption of these pathways may result in the generation of a population of cells with the capacity for unlimited self-renewal. Relevant data from mouse model systems are also discussed where appropriate. By understanding the molecular pathways that regulate self-renewal of normal mammary stem cells, it may be possible to target the activation of these pathways in breast tumours.
Affiliation:
Breast Biology Group, Division of Cancer Studies, University of Manchester, Christie Hospital, Wilmslow Road, Manchester, M20 4BX, UK.
Citation:
Human breast epithelial stem cells and their regulation. 2006, 208 (1):7-16 J. Pathol.
Journal:
The Journal of Pathology
Issue Date:
Jan-2006
URI:
http://hdl.handle.net/10541/72713
DOI:
10.1002/path.1881
PubMed ID:
16294373
Type:
Article
Language:
en
ISSN:
0022-3417
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorKalirai, Helen-
dc.contributor.authorClarke, Robert B-
dc.date.accessioned2009-07-07T10:03:36Z-
dc.date.available2009-07-07T10:03:36Z-
dc.date.issued2006-01-
dc.identifier.citationHuman breast epithelial stem cells and their regulation. 2006, 208 (1):7-16 J. Pathol.en
dc.identifier.issn0022-3417-
dc.identifier.pmid16294373-
dc.identifier.doi10.1002/path.1881-
dc.identifier.urihttp://hdl.handle.net/10541/72713-
dc.description.abstractThis review summarizes the current evidence for the existence of human breast stem cells and the pathways involved in their regulation, and discusses how the disruption of these pathways may result in the generation of a population of cells with the capacity for unlimited self-renewal. Relevant data from mouse model systems are also discussed where appropriate. By understanding the molecular pathways that regulate self-renewal of normal mammary stem cells, it may be possible to target the activation of these pathways in breast tumours.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectCancer Genesen
dc.subject.meshAdult-
dc.subject.meshBreast-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCell Division-
dc.subject.meshEpithelial Cells-
dc.subject.meshEstrogen Receptor alpha-
dc.subject.meshFemale-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshGenes, Neoplasm-
dc.subject.meshHumans-
dc.subject.meshMammary Glands, Human-
dc.subject.meshModels, Biological-
dc.subject.meshSignal Transduction-
dc.subject.meshStem Cells-
dc.titleHuman breast epithelial stem cells and their regulation.en
dc.typeArticleen
dc.contributor.departmentBreast Biology Group, Division of Cancer Studies, University of Manchester, Christie Hospital, Wilmslow Road, Manchester, M20 4BX, UK.en
dc.identifier.journalThe Journal of Pathologyen

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