Analysis of metal radioisotope impurities generated in [(18)O]H(2)O during the cyclotron production of fluorine-18.

2.50
Hdl Handle:
http://hdl.handle.net/10541/72681
Title:
Analysis of metal radioisotope impurities generated in [(18)O]H(2)O during the cyclotron production of fluorine-18.
Authors:
Gillies, James M; Najim, N; Zweit, Jamal
Abstract:
We show the separation of metal radioisotope impurities using capillary electrophoresis (CE). The methodology used is an improvement of existent protocols for separation of stable metal ions. Production of fluorine-18 using [(18)O]H(2)O-enriched water encased in a titanium target body results in the production of several metal radioisotope impurities. Optimisation of the conditions for CE separation of the metal radioisotope impurities incorporated the use of 6 mM 18-Crown-6 in combination with 12 mM glycolic acid as complexing agents within the running buffer (10 mM pyridine, pH 4.0). Using this optimised procedure, we were able to separate and detect a number of metal radioisotopes, including chromium, cobalt, manganese, vanadium and berillium, within the fM concentration range.
Affiliation:
Cancer Research-UK/UMIST Radiochemical Targeting and Imaging Group, Christie Hospital NHS Trust, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK. jgillies@picr.man.ac.uk
Citation:
Analysis of metal radioisotope impurities generated in [(18)O]H(2)O during the cyclotron production of fluorine-18. 2006, 64 (4):431-4 Appl Radiat Isot
Journal:
Applied Radiation and Isotopes
Issue Date:
Apr-2006
URI:
http://hdl.handle.net/10541/72681
DOI:
10.1016/j.apradiso.2005.08.008
PubMed ID:
16290946
Type:
Article
Language:
en
ISSN:
0969-8043
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorGillies, James M-
dc.contributor.authorNajim, N-
dc.contributor.authorZweit, Jamal-
dc.date.accessioned2009-07-07T10:06:02Z-
dc.date.available2009-07-07T10:06:02Z-
dc.date.issued2006-04-
dc.identifier.citationAnalysis of metal radioisotope impurities generated in [(18)O]H(2)O during the cyclotron production of fluorine-18. 2006, 64 (4):431-4 Appl Radiat Isoten
dc.identifier.issn0969-8043-
dc.identifier.pmid16290946-
dc.identifier.doi10.1016/j.apradiso.2005.08.008-
dc.identifier.urihttp://hdl.handle.net/10541/72681-
dc.description.abstractWe show the separation of metal radioisotope impurities using capillary electrophoresis (CE). The methodology used is an improvement of existent protocols for separation of stable metal ions. Production of fluorine-18 using [(18)O]H(2)O-enriched water encased in a titanium target body results in the production of several metal radioisotope impurities. Optimisation of the conditions for CE separation of the metal radioisotope impurities incorporated the use of 6 mM 18-Crown-6 in combination with 12 mM glycolic acid as complexing agents within the running buffer (10 mM pyridine, pH 4.0). Using this optimised procedure, we were able to separate and detect a number of metal radioisotopes, including chromium, cobalt, manganese, vanadium and berillium, within the fM concentration range.en
dc.language.isoenen
dc.subject.meshCyclotrons-
dc.subject.meshElectrophoresis, Capillary-
dc.subject.meshFluorine Radioisotopes-
dc.subject.meshMetals-
dc.subject.meshOxygen Isotopes-
dc.subject.meshWater-
dc.titleAnalysis of metal radioisotope impurities generated in [(18)O]H(2)O during the cyclotron production of fluorine-18.en
dc.typeArticleen
dc.contributor.departmentCancer Research-UK/UMIST Radiochemical Targeting and Imaging Group, Christie Hospital NHS Trust, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK. jgillies@picr.man.ac.uken
dc.identifier.journalApplied Radiation and Isotopesen

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