Analysis of metal radioisotope impurities generated in [(18)O]H(2)O during the cyclotron production of fluorine-18.
Affiliation
Cancer Research-UK/UMIST Radiochemical Targeting and Imaging Group, Christie Hospital NHS Trust, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK. jgillies@picr.man.ac.ukIssue Date
2006-04
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Show full item recordAbstract
We show the separation of metal radioisotope impurities using capillary electrophoresis (CE). The methodology used is an improvement of existent protocols for separation of stable metal ions. Production of fluorine-18 using [(18)O]H(2)O-enriched water encased in a titanium target body results in the production of several metal radioisotope impurities. Optimisation of the conditions for CE separation of the metal radioisotope impurities incorporated the use of 6 mM 18-Crown-6 in combination with 12 mM glycolic acid as complexing agents within the running buffer (10 mM pyridine, pH 4.0). Using this optimised procedure, we were able to separate and detect a number of metal radioisotopes, including chromium, cobalt, manganese, vanadium and berillium, within the fM concentration range.Citation
Analysis of metal radioisotope impurities generated in [(18)O]H(2)O during the cyclotron production of fluorine-18. 2006, 64 (4):431-4 Appl Radiat IsotJournal
Applied Radiation and IsotopesDOI
10.1016/j.apradiso.2005.08.008PubMed ID
16290946Type
ArticleLanguage
enISSN
0969-8043ae974a485f413a2113503eed53cd6c53
10.1016/j.apradiso.2005.08.008