Measurement of single kidney function using dynamic contrast-enhanced MRI: comparison of two models in human subjects.

2.50
Hdl Handle:
http://hdl.handle.net/10541/72625
Title:
Measurement of single kidney function using dynamic contrast-enhanced MRI: comparison of two models in human subjects.
Authors:
Buckley, David L; Shurrab, Ala'a E; Cheung, Ching M; Jones, Andrew P; Mamtora, Hari; Kalra, Philip A
Abstract:
PURPOSE: To compare two methods for assessing the single kidney glomerular filtration rate (SK-GFR) in humans using dynamic contrast-enhanced (DCE)-MRI. MATERIALS AND METHODS: Images were acquired from 39 separate MR studies of patients with atherosclerotic renovascular disease (ARVD). Data from the kidneys and descending aorta were analyzed using both a Rutland-Patlak plot and a compartmental model. MR estimates of the SK-GFR were compared with standard radioisotope measures in a total of 75 kidneys. RESULTS: Estimates of renal function using both techniques correlated well with radioisotope-assessed SK-GFR (Spearman's rho=0.81, Rutland-Patlak; rho=0.71, compartmental model). The Rutland-Patlak approach provided a near one-to-one correspondence, while the compartmental method tended to overestimate SK-GFR. However, the compartmental model fits to the experimental data were significantly better than those obtained using the Rutland-Patlak approach. CONCLUSION: DCE-MRI of the kidneys provides data that correlate well with reference measures of SK-GFR. However, further work, including image registration, is needed to isolate measurement of glomerular filtration to the level of the renal cortex.
Affiliation:
Imaging Science and Biomedical Engineering, University of Manchester, Manchester, and Department of Renal Medicine, Hope Hospital, Salford, United Kingdom. david.buckley@manchester.ac.uk
Citation:
Measurement of single kidney function using dynamic contrast-enhanced MRI: comparison of two models in human subjects. 2006, 24 (5):1117-23 J Magn Reson Imaging
Journal:
Journal of Magnetic Resonance Imaging
Issue Date:
Nov-2006
URI:
http://hdl.handle.net/10541/72625
DOI:
10.1002/jmri.20699
PubMed ID:
16941606
Type:
Article
Language:
en
ISSN:
1053-1807
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBuckley, David L-
dc.contributor.authorShurrab, Ala'a E-
dc.contributor.authorCheung, Ching M-
dc.contributor.authorJones, Andrew P-
dc.contributor.authorMamtora, Hari-
dc.contributor.authorKalra, Philip A-
dc.date.accessioned2009-07-06T15:45:05Z-
dc.date.available2009-07-06T15:45:05Z-
dc.date.issued2006-11-
dc.identifier.citationMeasurement of single kidney function using dynamic contrast-enhanced MRI: comparison of two models in human subjects. 2006, 24 (5):1117-23 J Magn Reson Imagingen
dc.identifier.issn1053-1807-
dc.identifier.pmid16941606-
dc.identifier.doi10.1002/jmri.20699-
dc.identifier.urihttp://hdl.handle.net/10541/72625-
dc.description.abstractPURPOSE: To compare two methods for assessing the single kidney glomerular filtration rate (SK-GFR) in humans using dynamic contrast-enhanced (DCE)-MRI. MATERIALS AND METHODS: Images were acquired from 39 separate MR studies of patients with atherosclerotic renovascular disease (ARVD). Data from the kidneys and descending aorta were analyzed using both a Rutland-Patlak plot and a compartmental model. MR estimates of the SK-GFR were compared with standard radioisotope measures in a total of 75 kidneys. RESULTS: Estimates of renal function using both techniques correlated well with radioisotope-assessed SK-GFR (Spearman's rho=0.81, Rutland-Patlak; rho=0.71, compartmental model). The Rutland-Patlak approach provided a near one-to-one correspondence, while the compartmental method tended to overestimate SK-GFR. However, the compartmental model fits to the experimental data were significantly better than those obtained using the Rutland-Patlak approach. CONCLUSION: DCE-MRI of the kidneys provides data that correlate well with reference measures of SK-GFR. However, further work, including image registration, is needed to isolate measurement of glomerular filtration to the level of the renal cortex.en
dc.language.isoenen
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAlgorithms-
dc.subject.meshComputer Simulation-
dc.subject.meshContrast Media-
dc.subject.meshFemale-
dc.subject.meshGadolinium DTPA-
dc.subject.meshHumans-
dc.subject.meshImage Enhancement-
dc.subject.meshImage Interpretation, Computer-Assisted-
dc.subject.meshKidney-
dc.subject.meshKidney Diseases-
dc.subject.meshKidney Function Tests-
dc.subject.meshKinetics-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshModels, Biological-
dc.subject.meshReproducibility of Results-
dc.subject.meshSensitivity and Specificity-
dc.titleMeasurement of single kidney function using dynamic contrast-enhanced MRI: comparison of two models in human subjects.en
dc.typeArticleen
dc.contributor.departmentImaging Science and Biomedical Engineering, University of Manchester, Manchester, and Department of Renal Medicine, Hope Hospital, Salford, United Kingdom. david.buckley@manchester.ac.uken
dc.identifier.journalJournal of Magnetic Resonance Imagingen
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