Measurement of single kidney function using dynamic contrast-enhanced MRI: comparison of two models in human subjects.
Affiliation
Imaging Science and Biomedical Engineering, University of Manchester, Manchester, and Department of Renal Medicine, Hope Hospital, Salford, United Kingdom. david.buckley@manchester.ac.ukIssue Date
2006-11
Metadata
Show full item recordAbstract
PURPOSE: To compare two methods for assessing the single kidney glomerular filtration rate (SK-GFR) in humans using dynamic contrast-enhanced (DCE)-MRI. MATERIALS AND METHODS: Images were acquired from 39 separate MR studies of patients with atherosclerotic renovascular disease (ARVD). Data from the kidneys and descending aorta were analyzed using both a Rutland-Patlak plot and a compartmental model. MR estimates of the SK-GFR were compared with standard radioisotope measures in a total of 75 kidneys. RESULTS: Estimates of renal function using both techniques correlated well with radioisotope-assessed SK-GFR (Spearman's rho=0.81, Rutland-Patlak; rho=0.71, compartmental model). The Rutland-Patlak approach provided a near one-to-one correspondence, while the compartmental method tended to overestimate SK-GFR. However, the compartmental model fits to the experimental data were significantly better than those obtained using the Rutland-Patlak approach. CONCLUSION: DCE-MRI of the kidneys provides data that correlate well with reference measures of SK-GFR. However, further work, including image registration, is needed to isolate measurement of glomerular filtration to the level of the renal cortex.Citation
Measurement of single kidney function using dynamic contrast-enhanced MRI: comparison of two models in human subjects. 2006, 24 (5):1117-23 J Magn Reson ImagingJournal
Journal of Magnetic Resonance ImagingDOI
10.1002/jmri.20699PubMed ID
16941606Type
ArticleLanguage
enISSN
1053-1807ae974a485f413a2113503eed53cd6c53
10.1002/jmri.20699
Scopus Count
Collections
Related articles
- Measurement of single-kidney glomerular filtration rate using a contrast-enhanced dynamic gradient-echo sequence and the Rutland-Patlak plot technique.
- Authors: Hackstein N, Heckrodt J, Rau WS
- Issue date: 2003 Dec
- Reproducibility of the aortic input function (AIF) derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the kidneys in a volunteer study.
- Authors: Mendichovszky IA, Cutajar M, Gordon I
- Issue date: 2009 Sep
- Feasibility study of high-resolution DCE-MRI for glomerular filtration rate (GFR) measurement in a routine clinical modal.
- Authors: Zhang YD, Wu CJ, Zhang J, Wang XN, Liu XS, Shi HB
- Issue date: 2015 Oct
- Tracer kinetics analysis of dynamic contrast-enhanced CT and MR data in patients with squamous cell carcinoma of the upper aerodigestive tract: comparison of the results.
- Authors: Bisdas S, Baghi M, Wagenblast J, Bisdas T, Thng CH, Mack MG, Koh TS, Ernemann U
- Issue date: 2009 Sep
- Quantitative analysis of dynamic contrast enhanced MRI for assessment of bowel inflammation in Crohn's disease pilot study.
- Authors: Oto A, Fan X, Mustafi D, Jansen SA, Karczmar GS, Rubin DT, Kayhan A
- Issue date: 2009 Oct