Second primary tumors in neurofibromatosis 1 patients treated for optic glioma: substantial risks after radiotherapy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/72619
Title:
Second primary tumors in neurofibromatosis 1 patients treated for optic glioma: substantial risks after radiotherapy.
Authors:
Sharif, Saba; Ferner, Rosalie; Birch, Jillian M; Gillespie, James E; Gattamaneni, Rao; Baser, Michael E; Evans, D Gareth R
Abstract:
PURPOSE: Optic pathway gliomas (OPGs) are the most common CNS tumor in neurofibromatosis 1 (NF1) patients. We evaluated the long-term risk of second tumors in NF1-related OPGs after radiotherapy. PATIENTS AND METHODS: We reviewed 80 NF1 OPG patients from two NF1 clinics to evaluate the long-term risk of developing subsequent nervous system tumors, with or without radiotherapy. RESULTS: Fifty-eight patients were assessable for second tumors. Nine (50%) of 18 patients who received radiotherapy after their OPGs developed 12 second tumors in 308 person-years of follow-up after radiotherapy. Eight (20%) of 40 patients who were not treated with radiotherapy developed nine tumors in 721 person-years of follow-up after diagnosis of their OPGs. The relative risk of second nervous system tumor after radiotherapy was 3.04 (95% CI, 1.29 to 7.15). CONCLUSION: There is a significantly increased risk of second nervous system tumors in those NF1 patients who received radiotherapy for their OPGs, especially when treated in childhood. Thus radiotherapy should only be used if absolutely essential in children with NF1.
Affiliation:
Department of Clinical Genetics, St Mary's Hospital, Manchester, United Kingdom.
Citation:
Second primary tumors in neurofibromatosis 1 patients treated for optic glioma: substantial risks after radiotherapy. 2006, 24 (16):2570-5 J. Clin. Oncol.
Journal:
Journal of Clinical Oncology
Issue Date:
1-Jun-2006
URI:
http://hdl.handle.net/10541/72619
DOI:
10.1200/JCO.2005.03.8349
PubMed ID:
16735710
Type:
Article
Language:
en
ISSN:
1527-7755
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorSharif, Saba-
dc.contributor.authorFerner, Rosalie-
dc.contributor.authorBirch, Jillian M-
dc.contributor.authorGillespie, James E-
dc.contributor.authorGattamaneni, Rao-
dc.contributor.authorBaser, Michael E-
dc.contributor.authorEvans, D Gareth R-
dc.date.accessioned2009-07-06T15:21:40Z-
dc.date.available2009-07-06T15:21:40Z-
dc.date.issued2006-06-01-
dc.identifier.citationSecond primary tumors in neurofibromatosis 1 patients treated for optic glioma: substantial risks after radiotherapy. 2006, 24 (16):2570-5 J. Clin. Oncol.en
dc.identifier.issn1527-7755-
dc.identifier.pmid16735710-
dc.identifier.doi10.1200/JCO.2005.03.8349-
dc.identifier.urihttp://hdl.handle.net/10541/72619-
dc.description.abstractPURPOSE: Optic pathway gliomas (OPGs) are the most common CNS tumor in neurofibromatosis 1 (NF1) patients. We evaluated the long-term risk of second tumors in NF1-related OPGs after radiotherapy. PATIENTS AND METHODS: We reviewed 80 NF1 OPG patients from two NF1 clinics to evaluate the long-term risk of developing subsequent nervous system tumors, with or without radiotherapy. RESULTS: Fifty-eight patients were assessable for second tumors. Nine (50%) of 18 patients who received radiotherapy after their OPGs developed 12 second tumors in 308 person-years of follow-up after radiotherapy. Eight (20%) of 40 patients who were not treated with radiotherapy developed nine tumors in 721 person-years of follow-up after diagnosis of their OPGs. The relative risk of second nervous system tumor after radiotherapy was 3.04 (95% CI, 1.29 to 7.15). CONCLUSION: There is a significantly increased risk of second nervous system tumors in those NF1 patients who received radiotherapy for their OPGs, especially when treated in childhood. Thus radiotherapy should only be used if absolutely essential in children with NF1.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshMale-
dc.subject.meshNeoplasms, Second Primary-
dc.subject.meshNeurofibromatosis 1-
dc.subject.meshOptic Nerve Glioma-
dc.subject.meshRadiotherapy-
dc.subject.meshRisk Assessment-
dc.subject.meshRisk Factors-
dc.titleSecond primary tumors in neurofibromatosis 1 patients treated for optic glioma: substantial risks after radiotherapy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Genetics, St Mary's Hospital, Manchester, United Kingdom.en
dc.identifier.journalJournal of Clinical Oncologyen

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