Effect of growth hormone in an experimental model of protein hypercatabolism induced by glucocorticoids.

2.50
Hdl Handle:
http://hdl.handle.net/10541/72616
Title:
Effect of growth hormone in an experimental model of protein hypercatabolism induced by glucocorticoids.
Authors:
Cantón, A; Trainer, Peter J; Martinez-Cáceres, E; Simó, R
Abstract:
OBJECTIVE: The aims of the study were to evaluate whether growth hormone could be beneficial in a model of hypercatabolism induced by glucocorticoids and to examine its effects on ACTH, corticosterone and IGF-1 levels. The effects of growth hormone on the expression of both glucocorticoid receptor and tyrosine aminotransferase were also evaluated. METHODS: Fifty Wistar rats were divided into five groups and treated as follows: (A) daily subcutaneous injection of growth hormone (4.8 IU/kg/day) and oral placebo, (B) daily injection of placebo and oral dexamethasone (3 mg/kg/day), (C) daily injection of growth hormone and oral dexamethasone, (D) daily injection of placebo and oral placebo, and (E) no treatment. The animals were decapitated seven days after initiating treatment. RESULTS: Growth hormone did not modify the weight loss induced by dexamethasone. Glucocorticoid receptor expression was significantly lower in group A than in group E. An increase in tyrosine aminotransferase was observed in group C. CONCLUSION: Growth hormone did not exert any beneficial effect in this model of hypercatabolism. Growth hormone decreased glucocorticoid receptor expression. This fact could explain its beneficial effect when protein hypercatabolism is not the predominant phenomenon. Growth hormone induced the hyperexpression of tyrosine aminotransferase, thus suggesting an amplifying effect on the glucocorticoid action.
Affiliation:
Department of Endocrinology, St Bartholomew's Hospital, London, UK. acanton.germanstrias@gencat.net
Citation:
Effect of growth hormone in an experimental model of protein hypercatabolism induced by glucocorticoids. 2006, 38 (9):556-62 Horm. Metab. Res.
Journal:
Hormone and Metabolic Research
Issue Date:
Sep-2006
URI:
http://hdl.handle.net/10541/72616
DOI:
10.1055/s-2006-950501
PubMed ID:
16981136
Type:
Article
Language:
en
ISSN:
1439-4286
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCantón, A-
dc.contributor.authorTrainer, Peter J-
dc.contributor.authorMartinez-Cáceres, E-
dc.contributor.authorSimó, R-
dc.date.accessioned2009-07-06T14:52:24Z-
dc.date.available2009-07-06T14:52:24Z-
dc.date.issued2006-09-
dc.identifier.citationEffect of growth hormone in an experimental model of protein hypercatabolism induced by glucocorticoids. 2006, 38 (9):556-62 Horm. Metab. Res.en
dc.identifier.issn1439-4286-
dc.identifier.pmid16981136-
dc.identifier.doi10.1055/s-2006-950501-
dc.identifier.urihttp://hdl.handle.net/10541/72616-
dc.description.abstractOBJECTIVE: The aims of the study were to evaluate whether growth hormone could be beneficial in a model of hypercatabolism induced by glucocorticoids and to examine its effects on ACTH, corticosterone and IGF-1 levels. The effects of growth hormone on the expression of both glucocorticoid receptor and tyrosine aminotransferase were also evaluated. METHODS: Fifty Wistar rats were divided into five groups and treated as follows: (A) daily subcutaneous injection of growth hormone (4.8 IU/kg/day) and oral placebo, (B) daily injection of placebo and oral dexamethasone (3 mg/kg/day), (C) daily injection of growth hormone and oral dexamethasone, (D) daily injection of placebo and oral placebo, and (E) no treatment. The animals were decapitated seven days after initiating treatment. RESULTS: Growth hormone did not modify the weight loss induced by dexamethasone. Glucocorticoid receptor expression was significantly lower in group A than in group E. An increase in tyrosine aminotransferase was observed in group C. CONCLUSION: Growth hormone did not exert any beneficial effect in this model of hypercatabolism. Growth hormone decreased glucocorticoid receptor expression. This fact could explain its beneficial effect when protein hypercatabolism is not the predominant phenomenon. Growth hormone induced the hyperexpression of tyrosine aminotransferase, thus suggesting an amplifying effect on the glucocorticoid action.en
dc.language.isoenen
dc.subject.meshAdrenocorticotropic Hormone-
dc.subject.meshAnimals-
dc.subject.meshBody Weight-
dc.subject.meshCorticosterone-
dc.subject.meshDexamethasone-
dc.subject.meshDisease Models, Animal-
dc.subject.meshGene Expression Regulation-
dc.subject.meshGlucocorticoids-
dc.subject.meshHuman Growth Hormone-
dc.subject.meshInsulin-Like Growth Factor I-
dc.subject.meshMale-
dc.subject.meshMetabolic Diseases-
dc.subject.meshProteins-
dc.subject.meshRats-
dc.subject.meshRats, Wistar-
dc.subject.meshReceptors, Glucocorticoid-
dc.subject.meshTyrosine Transaminase-
dc.titleEffect of growth hormone in an experimental model of protein hypercatabolism induced by glucocorticoids.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, St Bartholomew's Hospital, London, UK. acanton.germanstrias@gencat.neten
dc.identifier.journalHormone and Metabolic Researchen
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