Adolescents with childhood-onset GHD: how do we get them to peak bone mass?

2.50
Hdl Handle:
http://hdl.handle.net/10541/72615
Title:
Adolescents with childhood-onset GHD: how do we get them to peak bone mass?
Authors:
Shalet, Stephen M
Abstract:
The development of osteoporosis, with its attendant risk of fragility fracture, is in part related to the peak bone mass (PBM) achieved in early adulthood. Adolescence is a critical time for the acquisition of bone mass, with around 40% of skeletal mass being accrued during pubertal maturation. Growth hormone (GH) plays an integral role in the achievement of PBM after completion of linear growth, and several recent studies have suggested that GH replacement should continue in individuals with childhood-onset GHD until PBM has been attained - irrespective of the height achieved. In those with severe GHD after growth and pubertal development are complete, a seamless transition of GH therapy into adult life may be preferable to allowing a gap in GH treatment. The 'window of opportunity' concept for achieving PBM will, nevertheless, continue to be challenged by GHD teenagers who may resent the seamless continuation of GH replacement beyond adolescence. Preparation for this possibility should therefore begin during childhood, with all GHD teenagers being encouraged to remain on GH therapy until at least their mid-20s.
Affiliation:
Christie Hospital NHS Trust, Manchester, UK. stephen.m.shalet@man.ac.uk
Citation:
Adolescents with childhood-onset GHD: how do we get them to peak bone mass? 2006, 65 Suppl 2:17-22 Horm. Res.
Journal:
Hormone Research
Issue Date:
2006
URI:
http://hdl.handle.net/10541/72615
DOI:
10.1159/000091750
PubMed ID:
16707905
Type:
Article
Language:
en
ISSN:
0301-0163
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorShalet, Stephen M-
dc.date.accessioned2009-07-06T14:51:24Z-
dc.date.available2009-07-06T14:51:24Z-
dc.date.issued2006-
dc.identifier.citationAdolescents with childhood-onset GHD: how do we get them to peak bone mass? 2006, 65 Suppl 2:17-22 Horm. Res.en
dc.identifier.issn0301-0163-
dc.identifier.pmid16707905-
dc.identifier.doi10.1159/000091750-
dc.identifier.urihttp://hdl.handle.net/10541/72615-
dc.description.abstractThe development of osteoporosis, with its attendant risk of fragility fracture, is in part related to the peak bone mass (PBM) achieved in early adulthood. Adolescence is a critical time for the acquisition of bone mass, with around 40% of skeletal mass being accrued during pubertal maturation. Growth hormone (GH) plays an integral role in the achievement of PBM after completion of linear growth, and several recent studies have suggested that GH replacement should continue in individuals with childhood-onset GHD until PBM has been attained - irrespective of the height achieved. In those with severe GHD after growth and pubertal development are complete, a seamless transition of GH therapy into adult life may be preferable to allowing a gap in GH treatment. The 'window of opportunity' concept for achieving PBM will, nevertheless, continue to be challenged by GHD teenagers who may resent the seamless continuation of GH replacement beyond adolescence. Preparation for this possibility should therefore begin during childhood, with all GHD teenagers being encouraged to remain on GH therapy until at least their mid-20s.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshBody Height-
dc.subject.meshBone Density-
dc.subject.meshHuman Growth Hormone-
dc.subject.meshHumans-
dc.titleAdolescents with childhood-onset GHD: how do we get them to peak bone mass?en
dc.typeArticleen
dc.contributor.departmentChristie Hospital NHS Trust, Manchester, UK. stephen.m.shalet@man.ac.uken
dc.identifier.journalHormone Researchen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.