X-ray volumetric imaging in image-guided radiotherapy: the new standard in on-treatment imaging.

2.50
Hdl Handle:
http://hdl.handle.net/10541/72601
Title:
X-ray volumetric imaging in image-guided radiotherapy: the new standard in on-treatment imaging.
Authors:
McBain, Catherine A; Henry, Ann M; Sykes, Jonathan R; Amer, Ali M; Marchant, Thomas E; Moore, Christopher J; Davies, Julie; Stratford, Julia; McCarthy, Claire; Porritt, Bridget; Williams, Peter C; Khoo, Vincent S; Price, Patricia M
Abstract:
PURPOSE: X-ray volumetric imaging (XVI) for the first time allows for the on-treatment acquisition of three-dimensional (3D) kV cone beam computed tomography (CT) images. Clinical imaging using the Synergy System (Elekta, Crawley, UK) commenced in July 2003. This study evaluated image quality and dose delivered and assessed clinical utility for treatment verification at a range of anatomic sites. METHODS AND MATERIALS: Single XVIs were acquired from 30 patients undergoing radiotherapy for tumors at 10 different anatomic sites. Patients were imaged in their setup position. Radiation doses received were measured using TLDs on the skin surface. The utility of XVI in verifying target volume coverage was qualitatively assessed by experienced clinicians. RESULTS: X-ray volumetric imaging acquisition was completed in the treatment position at all anatomic sites. At sites where a full gantry rotation was not possible, XVIs were reconstructed from projection images acquired from partial rotations. Soft-tissue definition of organ boundaries allowed direct assessment of 3D target volume coverage at all sites. Individual image quality depended on both imaging parameters and patient characteristics. Radiation dose ranged from 0.003 Gy in the head to 0.03 Gy in the pelvis. CONCLUSIONS: On-treatment XVI provided 3D verification images with soft-tissue definition at all anatomic sites at acceptably low radiation doses. This technology sets a new standard in treatment verification and will facilitate novel adaptive radiotherapy techniques.
Affiliation:
Academic Department of Radiation Oncology, Christie Hospital NHS Trust, Manchester, England, United Kingdom. catherine.mcbain@christie-tr.nwest.nhs.uk
Citation:
X-ray volumetric imaging in image-guided radiotherapy: the new standard in on-treatment imaging. 2006, 64 (2):625-34 Int. J. Radiat. Oncol. Biol. Phys.
Journal:
International Journal of Radiation Oncology, Biology, Physics
Issue Date:
1-Feb-2006
URI:
http://hdl.handle.net/10541/72601
DOI:
10.1016/j.ijrobp.2005.09.018
PubMed ID:
16343802
Type:
Article
Language:
en
ISSN:
0360-3016
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMcBain, Catherine A-
dc.contributor.authorHenry, Ann M-
dc.contributor.authorSykes, Jonathan R-
dc.contributor.authorAmer, Ali M-
dc.contributor.authorMarchant, Thomas E-
dc.contributor.authorMoore, Christopher J-
dc.contributor.authorDavies, Julie-
dc.contributor.authorStratford, Julia-
dc.contributor.authorMcCarthy, Claire-
dc.contributor.authorPorritt, Bridget-
dc.contributor.authorWilliams, Peter C-
dc.contributor.authorKhoo, Vincent S-
dc.contributor.authorPrice, Patricia M-
dc.date.accessioned2009-07-06T14:17:25Z-
dc.date.available2009-07-06T14:17:25Z-
dc.date.issued2006-02-01-
dc.identifier.citationX-ray volumetric imaging in image-guided radiotherapy: the new standard in on-treatment imaging. 2006, 64 (2):625-34 Int. J. Radiat. Oncol. Biol. Phys.en
dc.identifier.issn0360-3016-
dc.identifier.pmid16343802-
dc.identifier.doi10.1016/j.ijrobp.2005.09.018-
dc.identifier.urihttp://hdl.handle.net/10541/72601-
dc.description.abstractPURPOSE: X-ray volumetric imaging (XVI) for the first time allows for the on-treatment acquisition of three-dimensional (3D) kV cone beam computed tomography (CT) images. Clinical imaging using the Synergy System (Elekta, Crawley, UK) commenced in July 2003. This study evaluated image quality and dose delivered and assessed clinical utility for treatment verification at a range of anatomic sites. METHODS AND MATERIALS: Single XVIs were acquired from 30 patients undergoing radiotherapy for tumors at 10 different anatomic sites. Patients were imaged in their setup position. Radiation doses received were measured using TLDs on the skin surface. The utility of XVI in verifying target volume coverage was qualitatively assessed by experienced clinicians. RESULTS: X-ray volumetric imaging acquisition was completed in the treatment position at all anatomic sites. At sites where a full gantry rotation was not possible, XVIs were reconstructed from projection images acquired from partial rotations. Soft-tissue definition of organ boundaries allowed direct assessment of 3D target volume coverage at all sites. Individual image quality depended on both imaging parameters and patient characteristics. Radiation dose ranged from 0.003 Gy in the head to 0.03 Gy in the pelvis. CONCLUSIONS: On-treatment XVI provided 3D verification images with soft-tissue definition at all anatomic sites at acceptably low radiation doses. This technology sets a new standard in treatment verification and will facilitate novel adaptive radiotherapy techniques.en
dc.language.isoenen
dc.subjectAbdominal Canceren
dc.subjectCentral Nervous System Canceren
dc.subjectHead and Neck Canceren
dc.subjectPelvic Canceren
dc.subjectThoracic Canceren
dc.subject.meshAbdominal Neoplasms-
dc.subject.meshCentral Nervous System Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHead and Neck Neoplasms-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshNeoplasms-
dc.subject.meshPelvic Neoplasms-
dc.subject.meshProspective Studies-
dc.subject.meshRadiographic Image Interpretation, Computer-Assisted-
dc.subject.meshRadiotherapy Dosage-
dc.subject.meshRadiotherapy Planning, Computer-Assisted-
dc.subject.meshRadiotherapy, Intensity-Modulated-
dc.subject.meshThoracic Neoplasms-
dc.subject.meshTomography, X-Ray Computed-
dc.titleX-ray volumetric imaging in image-guided radiotherapy: the new standard in on-treatment imaging.en
dc.typeArticleen
dc.contributor.departmentAcademic Department of Radiation Oncology, Christie Hospital NHS Trust, Manchester, England, United Kingdom. catherine.mcbain@christie-tr.nwest.nhs.uken
dc.identifier.journalInternational Journal of Radiation Oncology, Biology, Physicsen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.