Pathophysiology of radiation-induced growth hormone deficiency: efficacy and safety of GH replacement.

2.50
Hdl Handle:
http://hdl.handle.net/10541/72598
Title:
Pathophysiology of radiation-induced growth hormone deficiency: efficacy and safety of GH replacement.
Authors:
Darzy, Ken H; Shalet, Stephen M
Abstract:
Radiation-induced growth hormone deficiency (GHD) is primarily due to hypothalamic damage. GH secretion by the pituitary may be affected either secondary to some degree of quantitative deprivation of hypothalamic input or, if the radiation dose is high enough, by direct pituitary damage. As a consequence, the neurosecretory profile of GH secretion in an irradiated patient remains pulsatile and qualitatively intact. The frequency of pulse generation is unaffected, but the amplitude of the GH pulses is markedly reduced. Over the last 25 years, the final heights achieved by children receiving GH replacement for radiation-induced GHD have improved; these improvements are attributable to refinements in GH dosing schedules, increased use of GnRH analogues for radiation-induced precocious puberty, and a reduced time interval between completion of irradiation and initiation of GH therapy. When retested at the completion of growth, 80-90% of these teenagers are likely to prove severely GH deficient and, therefore, will potentially benefit from GH replacement in adult life. Such long-term GH treatment in patients treated previously for a brain tumor means that critical and continuous surveillance must be devoted to the risk of tumor recurrence and the possibility of second neoplasms.
Affiliation:
Department of Endocrinology, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, United Kingdom.
Citation:
Pathophysiology of radiation-induced growth hormone deficiency: efficacy and safety of GH replacement. 2006, 16 Suppl A:S30-40 Growth Horm. IGF Res.
Journal:
Growth Hormone & IGF Research
Issue Date:
Jul-2006
URI:
http://hdl.handle.net/10541/72598
DOI:
10.1016/j.ghir.2006.03.002
PubMed ID:
16624606
Type:
Article
Language:
en
ISSN:
1096-6374
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorDarzy, Ken H-
dc.contributor.authorShalet, Stephen M-
dc.date.accessioned2009-07-06T14:07:58Z-
dc.date.available2009-07-06T14:07:58Z-
dc.date.issued2006-07-
dc.identifier.citationPathophysiology of radiation-induced growth hormone deficiency: efficacy and safety of GH replacement. 2006, 16 Suppl A:S30-40 Growth Horm. IGF Res.en
dc.identifier.issn1096-6374-
dc.identifier.pmid16624606-
dc.identifier.doi10.1016/j.ghir.2006.03.002-
dc.identifier.urihttp://hdl.handle.net/10541/72598-
dc.description.abstractRadiation-induced growth hormone deficiency (GHD) is primarily due to hypothalamic damage. GH secretion by the pituitary may be affected either secondary to some degree of quantitative deprivation of hypothalamic input or, if the radiation dose is high enough, by direct pituitary damage. As a consequence, the neurosecretory profile of GH secretion in an irradiated patient remains pulsatile and qualitatively intact. The frequency of pulse generation is unaffected, but the amplitude of the GH pulses is markedly reduced. Over the last 25 years, the final heights achieved by children receiving GH replacement for radiation-induced GHD have improved; these improvements are attributable to refinements in GH dosing schedules, increased use of GnRH analogues for radiation-induced precocious puberty, and a reduced time interval between completion of irradiation and initiation of GH therapy. When retested at the completion of growth, 80-90% of these teenagers are likely to prove severely GH deficient and, therefore, will potentially benefit from GH replacement in adult life. Such long-term GH treatment in patients treated previously for a brain tumor means that critical and continuous surveillance must be devoted to the risk of tumor recurrence and the possibility of second neoplasms.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAbnormalities, Radiation-Induced-
dc.subject.meshAdult-
dc.subject.meshChild-
dc.subject.meshDrug Toxicity-
dc.subject.meshDwarfism, Pituitary-
dc.subject.meshGrowth Hormone-
dc.subject.meshGrowth and Development-
dc.subject.meshHormone Replacement Therapy-
dc.subject.meshHumans-
dc.subject.meshNeoplasms-
dc.subject.meshRadiobiology-
dc.subject.meshSurvivors-
dc.subject.meshTreatment Outcome-
dc.titlePathophysiology of radiation-induced growth hormone deficiency: efficacy and safety of GH replacement.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, United Kingdom.en
dc.identifier.journalGrowth Hormone & IGF Researchen

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