The putative role of transforming viruses in childhood acute lymphoblastic leukemia.

2.50
Hdl Handle:
http://hdl.handle.net/10541/72583
Title:
The putative role of transforming viruses in childhood acute lymphoblastic leukemia.
Authors:
MacKenzie, Jane; Greaves, Mel F; Eden, Tim O B; Clayton, Rob A; Perry, Jacqueline; Wilson, Katherine S; Jarrett, Ruth F
Abstract:
Epidemiological evidence suggests that infection is involved in the etiology of common acute lymphoblastic leukemia, either by stimulating an inappropriate immune response or in the form of a classical transforming agent. In an attempt to elucidate the role that infection is playing in this disease, we used representational difference analysis (RDA) to examine tumor samples for the presence of exogenous genomes. Twenty RDA experiments were carried out, using four different restriction enzymes, but no exogenous sequences were identified within leukemic cells. These results suggest that it is unlikely that a single, direct transforming agent is involved in the pathogenesis of common acute lymphoblastic leukemia.
Affiliation:
LRF Virus Centre, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK.
Citation:
The putative role of transforming viruses in childhood acute lymphoblastic leukemia. 2006, 91 (2):240-3 Haematologica
Journal:
Haematologica
Issue Date:
Feb-2006
URI:
http://hdl.handle.net/10541/72583
PubMed ID:
16461310
Type:
Article
Language:
en
ISSN:
1592-8721
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMacKenzie, Jane-
dc.contributor.authorGreaves, Mel F-
dc.contributor.authorEden, Tim O B-
dc.contributor.authorClayton, Rob A-
dc.contributor.authorPerry, Jacqueline-
dc.contributor.authorWilson, Katherine S-
dc.contributor.authorJarrett, Ruth F-
dc.date.accessioned2009-07-06T12:33:22Z-
dc.date.available2009-07-06T12:33:22Z-
dc.date.issued2006-02-
dc.identifier.citationThe putative role of transforming viruses in childhood acute lymphoblastic leukemia. 2006, 91 (2):240-3 Haematologicaen
dc.identifier.issn1592-8721-
dc.identifier.pmid16461310-
dc.identifier.urihttp://hdl.handle.net/10541/72583-
dc.description.abstractEpidemiological evidence suggests that infection is involved in the etiology of common acute lymphoblastic leukemia, either by stimulating an inappropriate immune response or in the form of a classical transforming agent. In an attempt to elucidate the role that infection is playing in this disease, we used representational difference analysis (RDA) to examine tumor samples for the presence of exogenous genomes. Twenty RDA experiments were carried out, using four different restriction enzymes, but no exogenous sequences were identified within leukemic cells. These results suggest that it is unlikely that a single, direct transforming agent is involved in the pathogenesis of common acute lymphoblastic leukemia.en
dc.language.isoenen
dc.subjectLeukaemia Lymphomaen
dc.subject.meshAdolescent-
dc.subject.meshCell Transformation, Viral-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshDNA, Neoplasm-
dc.subject.meshGenome, Viral-
dc.subject.meshGenomics-
dc.subject.meshHumans-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.titleThe putative role of transforming viruses in childhood acute lymphoblastic leukemia.en
dc.typeArticleen
dc.contributor.departmentLRF Virus Centre, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK.en
dc.identifier.journalHaematologicaen

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