Prospects for the development of long-acting formulations of human somatropin.

2.50
Hdl Handle:
http://hdl.handle.net/10541/72530
Title:
Prospects for the development of long-acting formulations of human somatropin.
Authors:
Jostel, Andreas; Shalet, Stephen M
Abstract:
In healthy humans, growth hormone (GH) is secreted in distinct pulses with an underlying nyctohemeral pattern. Current forms of somatropin replacement are unable to closely mimic such a release pattern, but are still able to exert the beneficial action of GH. A limited number of short-term studies in rodents and humans suggest that longitudinal growth may be superior when somatropin is given with a pulsatile mode of administration, whereas hepatic insulin-like growth factor-I generation and beneficial changes in body composition appear to be equal or even enhanced with continuous somatropin administration.Recent developments in drug delivery technology have allowed the use of slow-release preparations of somatropin in humans. The most successful technology so far has been the encapsulation of somatropin molecules in poly(D,L-lactic-co-glycolic acid) biodegradable microspheres. Pharmacokinetic and pharmacodynamic data have been published on two such preparations; Nutropin Depot((R)) and hGH-Biosphere((R)). The latter has a superior release profile, but outcomes data from multicenter trials in both children and adults have been presented for the former: catch-up growth was observed in children, although to a lesser degree than historic comparative data obtained with the use of daily somatropin injections and the effects on metabolic derangements in GH-deficient patients appeared similar to those observed with daily injections. Improved sustained-release somatropin preparations will need further study of their long-term efficacy, but, if successful, will be highly attractive in terms of patient compliance and convenience.
Affiliation:
Department of Endocrinology, Christie Hospital, Manchester, UK.
Citation:
Prospects for the development of long-acting formulations of human somatropin. 2006, 5 (3):139-45 Treat Endocrinol
Journal:
Treatments in Endocrinology
Issue Date:
2006
URI:
http://hdl.handle.net/10541/72530
DOI:
10.2165/00024677-200605030-00002
PubMed ID:
16677056
Type:
Article
Language:
en
ISSN:
1175-6349
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorJostel, Andreas-
dc.contributor.authorShalet, Stephen M-
dc.date.accessioned2009-07-06T09:02:09Z-
dc.date.available2009-07-06T09:02:09Z-
dc.date.issued2006-
dc.identifier.citationProspects for the development of long-acting formulations of human somatropin. 2006, 5 (3):139-45 Treat Endocrinolen
dc.identifier.issn1175-6349-
dc.identifier.pmid16677056-
dc.identifier.doi10.2165/00024677-200605030-00002-
dc.identifier.urihttp://hdl.handle.net/10541/72530-
dc.description.abstractIn healthy humans, growth hormone (GH) is secreted in distinct pulses with an underlying nyctohemeral pattern. Current forms of somatropin replacement are unable to closely mimic such a release pattern, but are still able to exert the beneficial action of GH. A limited number of short-term studies in rodents and humans suggest that longitudinal growth may be superior when somatropin is given with a pulsatile mode of administration, whereas hepatic insulin-like growth factor-I generation and beneficial changes in body composition appear to be equal or even enhanced with continuous somatropin administration.Recent developments in drug delivery technology have allowed the use of slow-release preparations of somatropin in humans. The most successful technology so far has been the encapsulation of somatropin molecules in poly(D,L-lactic-co-glycolic acid) biodegradable microspheres. Pharmacokinetic and pharmacodynamic data have been published on two such preparations; Nutropin Depot((R)) and hGH-Biosphere((R)). The latter has a superior release profile, but outcomes data from multicenter trials in both children and adults have been presented for the former: catch-up growth was observed in children, although to a lesser degree than historic comparative data obtained with the use of daily somatropin injections and the effects on metabolic derangements in GH-deficient patients appeared similar to those observed with daily injections. Improved sustained-release somatropin preparations will need further study of their long-term efficacy, but, if successful, will be highly attractive in terms of patient compliance and convenience.en
dc.language.isoenen
dc.subjectHuman Growth Hormoneen
dc.subjectSomatropinen
dc.subjectTreatment Outcomeen
dc.titleProspects for the development of long-acting formulations of human somatropin.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Manchester, UK.en
dc.identifier.journalTreatments in Endocrinologyen

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