Silent growth hormone secreting pituitary adenomas: IGF-1 is not sufficient to exclude growth hormone excess.

2.50
Hdl Handle:
http://hdl.handle.net/10541/71979
Title:
Silent growth hormone secreting pituitary adenomas: IGF-1 is not sufficient to exclude growth hormone excess.
Authors:
Kalavalapalli, S; Reid, H; Kane, J; Buckler, H; Trainer, Peter J; Heald, A H
Abstract:
Circulating insulin-like growth factor-1 (IGF-1) is increasingly being used as a screening test and in ongoing monitoring of treated acromegaly. We here present three cases of women (two of whom were on the oestrogen containing contraceptive pill at the time of presentation) who had normal circulating IGF-1 and no overt clinical features of acromegaly at the time of their pituitary surgery. Postoperatively, all were confirmed to have growth hormone excess in keeping with the presence of active somatotroph pituitary adenomas. We suggest that for optimal patient management, formal evaluation of growth hormone status with oral glucose tolerance testing should ideally be performed on all individuals for whom pituitary surgery is planned.
Affiliation:
Department of Endocrinology, University of Manchester, Salford NHS Trust, Salford M6 8HD, UK.
Citation:
Silent growth hormone secreting pituitary adenomas: IGF-1 is not sufficient to exclude growth hormone excess. 2007, 44 (Pt 1):89-93 Ann. Clin. Biochem.
Journal:
Annals of Clinical Biochemistry
Issue Date:
Jan-2007
URI:
http://hdl.handle.net/10541/71979
DOI:
10.1258/000456307779596075
PubMed ID:
17270100
Type:
Article
Language:
en
ISSN:
0004-5632
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorKalavalapalli, S-
dc.contributor.authorReid, H-
dc.contributor.authorKane, J-
dc.contributor.authorBuckler, H-
dc.contributor.authorTrainer, Peter J-
dc.contributor.authorHeald, A H-
dc.date.accessioned2009-06-30T14:27:24Z-
dc.date.available2009-06-30T14:27:24Z-
dc.date.issued2007-01-
dc.identifier.citationSilent growth hormone secreting pituitary adenomas: IGF-1 is not sufficient to exclude growth hormone excess. 2007, 44 (Pt 1):89-93 Ann. Clin. Biochem.en
dc.identifier.issn0004-5632-
dc.identifier.pmid17270100-
dc.identifier.doi10.1258/000456307779596075-
dc.identifier.urihttp://hdl.handle.net/10541/71979-
dc.description.abstractCirculating insulin-like growth factor-1 (IGF-1) is increasingly being used as a screening test and in ongoing monitoring of treated acromegaly. We here present three cases of women (two of whom were on the oestrogen containing contraceptive pill at the time of presentation) who had normal circulating IGF-1 and no overt clinical features of acromegaly at the time of their pituitary surgery. Postoperatively, all were confirmed to have growth hormone excess in keeping with the presence of active somatotroph pituitary adenomas. We suggest that for optimal patient management, formal evaluation of growth hormone status with oral glucose tolerance testing should ideally be performed on all individuals for whom pituitary surgery is planned.en
dc.language.isoenen
dc.subject.meshAcromegaly-
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshContraceptives, Oral, Hormonal-
dc.subject.meshFemale-
dc.subject.meshGrowth Hormone-
dc.subject.meshGrowth Hormone-Secreting Pituitary Adenoma-
dc.subject.meshHumans-
dc.subject.meshInsulin-Like Growth Factor I-
dc.titleSilent growth hormone secreting pituitary adenomas: IGF-1 is not sufficient to exclude growth hormone excess.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, University of Manchester, Salford NHS Trust, Salford M6 8HD, UK.en
dc.identifier.journalAnnals of Clinical Biochemistryen
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