Metabolic effects of growth hormone (GH) replacement in children and adolescents with severe isolated GH deficiency due to a GHRH receptor mutation.

2.50
Hdl Handle:
http://hdl.handle.net/10541/71962
Title:
Metabolic effects of growth hormone (GH) replacement in children and adolescents with severe isolated GH deficiency due to a GHRH receptor mutation.
Authors:
Gleeson, Helena K; Barreto, Elenilde S de A; Salvatori, Roberto; Costa, Liana; Oliveira, Carla R P; Pereira, Rossana M C; Clayton, Peter E; Aguiar-Oliveira, Manuel H
Abstract:
BACKGROUND: The interpretation of the true effect of GH replacement therapy (GHRT) on metabolic status in GH deficiency (GHD) is often complicated by differing aetiologies of GHD and by the presence of additional hormone deficits. OBJECTIVE: To study the growth and response of the lipid profile and body composition to GHRT in a cohort of children with the same mutation in the GHRH receptor gene. Design Nine GH-deficient subjects (mean age 12.8 years, range 5-17.5 years; three male) in a rural community in Northeast Brazil were treated with GHRT for 2 years and compared with indigenous normal controls. MAIN OUTCOME MEASURES: Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG) and body composition were measured at baseline and after 3, 12 and 24 months of GHRT. RESULTS: At baseline, the subjects with GHD had an adverse lipid profile, including elevated TC, elevated LDL-C and elevated TG. GHRT normalized TG in 3 months, LDL-C in 12 months and TC in 24 months. At baseline, older pubertal subjects with GHD had adverse body composition, including higher percentage fat mass (%FM), and GHRT induced a reduction in %FM that was maintained after 24 months. By contrast, younger prepubertal subjects did not have an adverse body composition. CONCLUSIONS: Lipid profile was abnormal at baseline, while abnormal body composition was only seen in older subjects in late puberty, indicating that body composition is less sensitive to the effect of GHD than lipid profile. GHRT improves lipid profile at all ages, while it affects body composition only towards the end of growth, emphasizing its importance in achieving normal somatic development in the transition period.
Affiliation:
Christie Hospital, Department of Endocrinology, Manchester, UK. helena@kgleeson99.freeserve.co.uk
Citation:
Metabolic effects of growth hormone (GH) replacement in children and adolescents with severe isolated GH deficiency due to a GHRH receptor mutation. 2007, 66 (4):466-74 Clin. Endocrinol.
Journal:
Clinical Endocrinology
Issue Date:
Apr-2007
URI:
http://hdl.handle.net/10541/71962
DOI:
10.1111/j.1365-2265.2007.02753.x
PubMed ID:
17371461
Type:
Article
Language:
en
ISSN:
0300-0664
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorGleeson, Helena K-
dc.contributor.authorBarreto, Elenilde S de A-
dc.contributor.authorSalvatori, Roberto-
dc.contributor.authorCosta, Liana-
dc.contributor.authorOliveira, Carla R P-
dc.contributor.authorPereira, Rossana M C-
dc.contributor.authorClayton, Peter E-
dc.contributor.authorAguiar-Oliveira, Manuel H-
dc.date.accessioned2009-06-30T14:20:17Z-
dc.date.available2009-06-30T14:20:17Z-
dc.date.issued2007-04-
dc.identifier.citationMetabolic effects of growth hormone (GH) replacement in children and adolescents with severe isolated GH deficiency due to a GHRH receptor mutation. 2007, 66 (4):466-74 Clin. Endocrinol.en
dc.identifier.issn0300-0664-
dc.identifier.pmid17371461-
dc.identifier.doi10.1111/j.1365-2265.2007.02753.x-
dc.identifier.urihttp://hdl.handle.net/10541/71962-
dc.description.abstractBACKGROUND: The interpretation of the true effect of GH replacement therapy (GHRT) on metabolic status in GH deficiency (GHD) is often complicated by differing aetiologies of GHD and by the presence of additional hormone deficits. OBJECTIVE: To study the growth and response of the lipid profile and body composition to GHRT in a cohort of children with the same mutation in the GHRH receptor gene. Design Nine GH-deficient subjects (mean age 12.8 years, range 5-17.5 years; three male) in a rural community in Northeast Brazil were treated with GHRT for 2 years and compared with indigenous normal controls. MAIN OUTCOME MEASURES: Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG) and body composition were measured at baseline and after 3, 12 and 24 months of GHRT. RESULTS: At baseline, the subjects with GHD had an adverse lipid profile, including elevated TC, elevated LDL-C and elevated TG. GHRT normalized TG in 3 months, LDL-C in 12 months and TC in 24 months. At baseline, older pubertal subjects with GHD had adverse body composition, including higher percentage fat mass (%FM), and GHRT induced a reduction in %FM that was maintained after 24 months. By contrast, younger prepubertal subjects did not have an adverse body composition. CONCLUSIONS: Lipid profile was abnormal at baseline, while abnormal body composition was only seen in older subjects in late puberty, indicating that body composition is less sensitive to the effect of GHD than lipid profile. GHRT improves lipid profile at all ages, while it affects body composition only towards the end of growth, emphasizing its importance in achieving normal somatic development in the transition period.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAnalysis of Variance-
dc.subject.meshBody Composition-
dc.subject.meshCase-Control Studies-
dc.subject.meshChild-
dc.subject.meshCholesterol-
dc.subject.meshCholesterol, HDL-
dc.subject.meshCholesterol, LDL-
dc.subject.meshFemale-
dc.subject.meshGene Deletion-
dc.subject.meshGrowth Disorders-
dc.subject.meshGrowth Hormone-
dc.subject.meshHemoglobin A, Glycosylated-
dc.subject.meshHomozygote-
dc.subject.meshHormone Replacement Therapy-
dc.subject.meshHuman Growth Hormone-
dc.subject.meshHumans-
dc.subject.meshInsulin-Like Growth Factor I-
dc.subject.meshMale-
dc.subject.meshMutation-
dc.subject.meshReceptors, Neuropeptide-
dc.subject.meshReceptors, Pituitary Hormone-Regulating Hormone-
dc.subject.meshTreatment Outcome-
dc.subject.meshTriglycerides-
dc.titleMetabolic effects of growth hormone (GH) replacement in children and adolescents with severe isolated GH deficiency due to a GHRH receptor mutation.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital, Department of Endocrinology, Manchester, UK. helena@kgleeson99.freeserve.co.uken
dc.identifier.journalClinical Endocrinologyen

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