Arthritic pain is processed in brain areas concerned with emotions and fear.

2.50
Hdl Handle:
http://hdl.handle.net/10541/71960
Title:
Arthritic pain is processed in brain areas concerned with emotions and fear.
Authors:
Kulkarni, Bhavna; Bentley, D E; Elliott, R; Julyan, Peter J; Boger, E; Watson, A; Boyle, Y; El-Deredy, W; Jones, Anthony K P
Abstract:
OBJECTIVE: Functional neuroimaging studies have shown that experimentally induced acute pain is processed within at least 2 parallel networks of brain structures collectively known as the pain matrix. The relevance of this finding to clinical pain is not known, because no direct comparisons of experimental and clinical pain have been performed in the same group of patients. The aim of this study was to compare directly the brain areas involved in processing arthritic pain and experimental pain in a group of patients with osteoarthritis (OA). METHODS: Twelve patients with knee OA underwent positron emission tomography of the brain, using (18)F-fluorodeoxyglucose (FDG). Scanning was performed during 3 different pain states: arthritic knee pain, experimental knee pain, and pain-free. Significant differences in the neuronal uptake of FDG between different pain states were investigated using statistical parametric mapping software. RESULTS: Both pain conditions activated the pain matrix, but arthritic pain was associated with increased activity in the cingulate cortex, the thalamus, and the amygdala; these areas are involved in the processing of fear, emotions, and in aversive conditioning. CONCLUSION: Our results suggest that studies of experimental pain provide a relevant but quantitatively incomplete picture of brain activity during arthritic pain. The search for new analgesics for arthritis that act on the brain should focus on drugs that modify this circuitry.
Affiliation:
Human Pain Research Group, University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford, UK. bhavna.kulkarni@manchester.ac.uk
Citation:
Arthritic pain is processed in brain areas concerned with emotions and fear. 2007, 56 (4):1345-54 Arthritis Rheum.
Journal:
Arthritis and Rheumatism
Issue Date:
Apr-2007
URI:
http://hdl.handle.net/10541/71960
DOI:
10.1002/art.22460
PubMed ID:
17393440
Type:
Article
Language:
en
ISSN:
0004-3591
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorKulkarni, Bhavna-
dc.contributor.authorBentley, D E-
dc.contributor.authorElliott, R-
dc.contributor.authorJulyan, Peter J-
dc.contributor.authorBoger, E-
dc.contributor.authorWatson, A-
dc.contributor.authorBoyle, Y-
dc.contributor.authorEl-Deredy, W-
dc.contributor.authorJones, Anthony K P-
dc.date.accessioned2009-06-30T14:16:36Z-
dc.date.available2009-06-30T14:16:36Z-
dc.date.issued2007-04-
dc.identifier.citationArthritic pain is processed in brain areas concerned with emotions and fear. 2007, 56 (4):1345-54 Arthritis Rheum.en
dc.identifier.issn0004-3591-
dc.identifier.pmid17393440-
dc.identifier.doi10.1002/art.22460-
dc.identifier.urihttp://hdl.handle.net/10541/71960-
dc.description.abstractOBJECTIVE: Functional neuroimaging studies have shown that experimentally induced acute pain is processed within at least 2 parallel networks of brain structures collectively known as the pain matrix. The relevance of this finding to clinical pain is not known, because no direct comparisons of experimental and clinical pain have been performed in the same group of patients. The aim of this study was to compare directly the brain areas involved in processing arthritic pain and experimental pain in a group of patients with osteoarthritis (OA). METHODS: Twelve patients with knee OA underwent positron emission tomography of the brain, using (18)F-fluorodeoxyglucose (FDG). Scanning was performed during 3 different pain states: arthritic knee pain, experimental knee pain, and pain-free. Significant differences in the neuronal uptake of FDG between different pain states were investigated using statistical parametric mapping software. RESULTS: Both pain conditions activated the pain matrix, but arthritic pain was associated with increased activity in the cingulate cortex, the thalamus, and the amygdala; these areas are involved in the processing of fear, emotions, and in aversive conditioning. CONCLUSION: Our results suggest that studies of experimental pain provide a relevant but quantitatively incomplete picture of brain activity during arthritic pain. The search for new analgesics for arthritis that act on the brain should focus on drugs that modify this circuitry.en
dc.language.isoenen
dc.subject.meshAged-
dc.subject.meshBrain-
dc.subject.meshBrain Mapping-
dc.subject.meshEmotions-
dc.subject.meshFear-
dc.subject.meshFemale-
dc.subject.meshHot Temperature-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshOsteoarthritis, Knee-
dc.subject.meshPain-
dc.subject.meshPain Measurement-
dc.subject.meshPhysical Stimulation-
dc.subject.meshPositron-Emission Tomography-
dc.titleArthritic pain is processed in brain areas concerned with emotions and fear.en
dc.typeArticleen
dc.contributor.departmentHuman Pain Research Group, University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford, UK. bhavna.kulkarni@manchester.ac.uken
dc.identifier.journalArthritis and Rheumatismen

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