Distinct roles of free leptin, bound leptin and soluble leptin receptor during the metabolic-inflammatory response in patients with liver cirrhosis.

2.50
Hdl Handle:
http://hdl.handle.net/10541/71958
Title:
Distinct roles of free leptin, bound leptin and soluble leptin receptor during the metabolic-inflammatory response in patients with liver cirrhosis.
Authors:
Ockenga, J; Tietge, U J F; Böker, K H W; Manns, M P; Brabant, Georg E; Bahr, M J
Abstract:
BACKGROUND: Alteration of the leptin system appears to play a role in the inflammatory-metabolic response in catabolic diseases such as chronic liver diseases. AIM: To investigate the association between leptin components, inflammatory markers and hepatic energy and substrate metabolism. METHODS: We investigated in vivo hepatic substrate and leptin metabolism in 40 patients employing a combination of arterial and hepatic vein catheterization techniques and hepatic blood flow measurements. In addition to metabolic, inflammatory and neuroendocrine parameters, circulating levels of free leptin, bound leptin and soluble leptin receptor were determined. RESULTS: Compared with controls, bound leptin and soluble leptin receptor levels were significantly elevated in cirrhosis, while free leptin did not increase. In cirrhosis bound leptin was correlated with soluble leptin receptor (r = 0.70, P < 0.001). Free leptin was positively correlated with metabolic parameters such as energy storage (body fat mass; r = 0.36, P < 0.05), insulin and insulin resistance (r = 0.48; r = 0.46, P < 0.01) as well as with hepatic glucose and energy release (r = 0.35 and r = 0.40, P < 0.05). In contrast, bound leptin and soluble leptin receptor were linked to proinflammatory cytokines and sympathetic activity (r = 0.61 and r = 0.56, P < 0.01). CONCLUSION: The components of the leptin system (free leptin, bound leptin and soluble leptin receptor) have distinct roles in metabolic and inflammatory processes in patients with liver cirrhosis. The better understanding of this metabolic and inflammatory tissue-repair response may lead to innovative new therapeutic strategies in liver disease as well as in various other catabolic diseases.
Affiliation:
Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany. johann.ockenga@charite.de
Citation:
Distinct roles of free leptin, bound leptin and soluble leptin receptor during the metabolic-inflammatory response in patients with liver cirrhosis. 2007, 25 (11):1301-9 Aliment. Pharmacol. Ther.
Journal:
Alimentary Pharmacology & Therapeutics
Issue Date:
1-Jun-2007
URI:
http://hdl.handle.net/10541/71958
DOI:
10.1111/j.1365-2036.2007.03327.x
PubMed ID:
17509098
Type:
Article
Language:
en
ISSN:
0269-2813
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorOckenga, J-
dc.contributor.authorTietge, U J F-
dc.contributor.authorBöker, K H W-
dc.contributor.authorManns, M P-
dc.contributor.authorBrabant, Georg E-
dc.contributor.authorBahr, M J-
dc.date.accessioned2009-06-30T14:11:34Z-
dc.date.available2009-06-30T14:11:34Z-
dc.date.issued2007-06-01-
dc.identifier.citationDistinct roles of free leptin, bound leptin and soluble leptin receptor during the metabolic-inflammatory response in patients with liver cirrhosis. 2007, 25 (11):1301-9 Aliment. Pharmacol. Ther.en
dc.identifier.issn0269-2813-
dc.identifier.pmid17509098-
dc.identifier.doi10.1111/j.1365-2036.2007.03327.x-
dc.identifier.urihttp://hdl.handle.net/10541/71958-
dc.description.abstractBACKGROUND: Alteration of the leptin system appears to play a role in the inflammatory-metabolic response in catabolic diseases such as chronic liver diseases. AIM: To investigate the association between leptin components, inflammatory markers and hepatic energy and substrate metabolism. METHODS: We investigated in vivo hepatic substrate and leptin metabolism in 40 patients employing a combination of arterial and hepatic vein catheterization techniques and hepatic blood flow measurements. In addition to metabolic, inflammatory and neuroendocrine parameters, circulating levels of free leptin, bound leptin and soluble leptin receptor were determined. RESULTS: Compared with controls, bound leptin and soluble leptin receptor levels were significantly elevated in cirrhosis, while free leptin did not increase. In cirrhosis bound leptin was correlated with soluble leptin receptor (r = 0.70, P < 0.001). Free leptin was positively correlated with metabolic parameters such as energy storage (body fat mass; r = 0.36, P < 0.05), insulin and insulin resistance (r = 0.48; r = 0.46, P < 0.01) as well as with hepatic glucose and energy release (r = 0.35 and r = 0.40, P < 0.05). In contrast, bound leptin and soluble leptin receptor were linked to proinflammatory cytokines and sympathetic activity (r = 0.61 and r = 0.56, P < 0.01). CONCLUSION: The components of the leptin system (free leptin, bound leptin and soluble leptin receptor) have distinct roles in metabolic and inflammatory processes in patients with liver cirrhosis. The better understanding of this metabolic and inflammatory tissue-repair response may lead to innovative new therapeutic strategies in liver disease as well as in various other catabolic diseases.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshCase-Control Studies-
dc.subject.meshCytokines-
dc.subject.meshFemale-
dc.subject.meshHepatitis-
dc.subject.meshHumans-
dc.subject.meshLeptin-
dc.subject.meshLiver Cirrhosis-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshReceptors, Leptin-
dc.titleDistinct roles of free leptin, bound leptin and soluble leptin receptor during the metabolic-inflammatory response in patients with liver cirrhosis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany. johann.ockenga@charite.deen
dc.identifier.journalAlimentary Pharmacology & Therapeuticsen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.