Low-dose lenograstim is as effective as standard dose in shortening neutrophil engraftment time following myeloablative chemotherapy and peripheral blood progenitor cell rescue.

2.50
Hdl Handle:
http://hdl.handle.net/10541/71928
Title:
Low-dose lenograstim is as effective as standard dose in shortening neutrophil engraftment time following myeloablative chemotherapy and peripheral blood progenitor cell rescue.
Authors:
Nolan, L; Lorigan, Paul C ( 0000-0002-8875-2164 ) ; Chilton, S; Newman, J; Else, R; Smith, P; Linch, David C; Sweetenham, J W; Johnson, Peter W
Abstract:
Granulocyte colony-stimulating factor (G-CSF) is widely used following myeloablative chemotherapy (high-dose therapy; HDT) and peripheral blood progenitor cell rescue (PBPCR) to reduce neutrophil engraftment time. The dose and duration required to gain maximum clinical and economic benefit has not been fully investigated. This double blind placebo-controlled randomised trial was performed to determine whether short course low-dose or standard-dose Lenograstim (L) would influence recovery of haematopoiesis following HDT and PBPCR. Sixty-one patients were randomised between May 1999 and November 2004, to receive standard-dose lenograstim (263 microg/d), low-dose lenograstim (105 microg/d) or placebo injections. These commenced on day +5 following PBPCR and continued until neutrophil engraftment [absolute neutrophil count (ANC)] > or = 0.5 x 10(9)/l. Patients received standard supportive care until haemopoietic recovery. Both standard- and low-dose lenograstim resulted in a significantly shorter median time to neutrophil recovery (ANC > or = 0.1 x 10(9)/l:10.0 vs. 11.0 d, P = 0.025; ANC > or = 0.5 x 10(9)/l:11.0 vs. 14.0 d, P = 0.0002) compared with placebo. There was no significant difference in blood product support, antibiotic usage, documented infection, overall survival or relapse-free survival between the groups. Short course low-dose lenograstim is as effective as standard-dose in reducing neutrophil engraftment time following HDT and PBPCR.
Affiliation:
Cancer Research UK Clinical Centre, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, UK.
Citation:
Low-dose lenograstim is as effective as standard dose in shortening neutrophil engraftment time following myeloablative chemotherapy and peripheral blood progenitor cell rescue. 2007, 137 (5):436-42 Br. J. Haematol.
Journal:
British Journal of Haematology
Issue Date:
Jun-2007
URI:
http://hdl.handle.net/10541/71928
DOI:
10.1111/j.1365-2141.2007.06587.x
PubMed ID:
17433027
Type:
Article
Language:
en
ISSN:
0007-1048
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorNolan, L-
dc.contributor.authorLorigan, Paul C-
dc.contributor.authorChilton, S-
dc.contributor.authorNewman, J-
dc.contributor.authorElse, R-
dc.contributor.authorSmith, P-
dc.contributor.authorLinch, David C-
dc.contributor.authorSweetenham, J W-
dc.contributor.authorJohnson, Peter W-
dc.date.accessioned2009-06-30T12:15:52Z-
dc.date.available2009-06-30T12:15:52Z-
dc.date.issued2007-06-
dc.identifier.citationLow-dose lenograstim is as effective as standard dose in shortening neutrophil engraftment time following myeloablative chemotherapy and peripheral blood progenitor cell rescue. 2007, 137 (5):436-42 Br. J. Haematol.en
dc.identifier.issn0007-1048-
dc.identifier.pmid17433027-
dc.identifier.doi10.1111/j.1365-2141.2007.06587.x-
dc.identifier.urihttp://hdl.handle.net/10541/71928-
dc.description.abstractGranulocyte colony-stimulating factor (G-CSF) is widely used following myeloablative chemotherapy (high-dose therapy; HDT) and peripheral blood progenitor cell rescue (PBPCR) to reduce neutrophil engraftment time. The dose and duration required to gain maximum clinical and economic benefit has not been fully investigated. This double blind placebo-controlled randomised trial was performed to determine whether short course low-dose or standard-dose Lenograstim (L) would influence recovery of haematopoiesis following HDT and PBPCR. Sixty-one patients were randomised between May 1999 and November 2004, to receive standard-dose lenograstim (263 microg/d), low-dose lenograstim (105 microg/d) or placebo injections. These commenced on day +5 following PBPCR and continued until neutrophil engraftment [absolute neutrophil count (ANC)] > or = 0.5 x 10(9)/l. Patients received standard supportive care until haemopoietic recovery. Both standard- and low-dose lenograstim resulted in a significantly shorter median time to neutrophil recovery (ANC > or = 0.1 x 10(9)/l:10.0 vs. 11.0 d, P = 0.025; ANC > or = 0.5 x 10(9)/l:11.0 vs. 14.0 d, P = 0.0002) compared with placebo. There was no significant difference in blood product support, antibiotic usage, documented infection, overall survival or relapse-free survival between the groups. Short course low-dose lenograstim is as effective as standard-dose in reducing neutrophil engraftment time following HDT and PBPCR.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshBlood Cell Count-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshDisease-Free Survival-
dc.subject.meshDouble-Blind Method-
dc.subject.meshDrug Administration Schedule-
dc.subject.meshFemale-
dc.subject.meshGranulocyte Colony-Stimulating Factor-
dc.subject.meshHodgkin Disease-
dc.subject.meshHumans-
dc.subject.meshLymphoma, Non-Hodgkin-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMyeloablative Agonists-
dc.subject.meshNeutrophils-
dc.subject.meshPeripheral Blood Stem Cell Transplantation-
dc.subject.meshProspective Studies-
dc.subject.meshRecombinant Proteins-
dc.titleLow-dose lenograstim is as effective as standard dose in shortening neutrophil engraftment time following myeloablative chemotherapy and peripheral blood progenitor cell rescue.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Clinical Centre, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, UK.en
dc.identifier.journalBritish Journal of Haematologyen

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