The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.

2.50
Hdl Handle:
http://hdl.handle.net/10541/71361
Title:
The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.
Authors:
Hornillo-Araujo, Ana R; Burrell, Adam J M; Aiertza, Miren K; Shibata, Takayuki; Hammond, David M; Edmont, Dolores; Adams, Harry; Margison, Geoffrey P; Williams, David M
Abstract:
The syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogues of O(6)-methylguanine and S(6)-methylthioguanine are described. The crystal structures and pK(a) values of these analogues are reported. In a standard substrate assay with the human repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity.
Affiliation:
Centre for Chemical Biology, Department of Chemistry, University of Sheffield, Sheffield, United Kingdom.
Citation:
The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine. 2007, 26 (8-9):1099-102 Nucleosides Nucleotides Nucleic Acids
Journal:
Nucleosides, Nucleotides & Nucleic Acids
Issue Date:
2007
URI:
http://hdl.handle.net/10541/71361
DOI:
10.1080/15257770701519221
PubMed ID:
18058544
Type:
Article
Language:
en
ISSN:
1525-7770
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHornillo-Araujo, Ana R-
dc.contributor.authorBurrell, Adam J M-
dc.contributor.authorAiertza, Miren K-
dc.contributor.authorShibata, Takayuki-
dc.contributor.authorHammond, David M-
dc.contributor.authorEdmont, Dolores-
dc.contributor.authorAdams, Harry-
dc.contributor.authorMargison, Geoffrey P-
dc.contributor.authorWilliams, David M-
dc.date.accessioned2009-06-23T15:44:49Z-
dc.date.available2009-06-23T15:44:49Z-
dc.date.issued2007-
dc.identifier.citationThe synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine. 2007, 26 (8-9):1099-102 Nucleosides Nucleotides Nucleic Acidsen
dc.identifier.issn1525-7770-
dc.identifier.pmid18058544-
dc.identifier.doi10.1080/15257770701519221-
dc.identifier.urihttp://hdl.handle.net/10541/71361-
dc.description.abstractThe syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogues of O(6)-methylguanine and S(6)-methylthioguanine are described. The crystal structures and pK(a) values of these analogues are reported. In a standard substrate assay with the human repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity.en
dc.language.isoenen
dc.subject.meshCrystallography, X-Ray-
dc.subject.meshDrug Design-
dc.subject.meshEnzyme Inhibitors-
dc.subject.meshGuanine-
dc.subject.meshHumans-
dc.subject.meshKinetics-
dc.subject.meshMolecular Structure-
dc.subject.meshO(6)-Methylguanine-DNA Methyltransferase-
dc.titleThe synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.en
dc.typeArticleen
dc.contributor.departmentCentre for Chemical Biology, Department of Chemistry, University of Sheffield, Sheffield, United Kingdom.en
dc.identifier.journalNucleosides, Nucleotides & Nucleic Acidsen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.