2.50
Hdl Handle:
http://hdl.handle.net/10541/71279
Title:
A key role for the GINS complex at DNA replication forks
Authors:
Labib, Karim; Gambus, Agnieszka
Abstract:
The GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome replication and also for the normal progression of DNA replication forks. Several recent studies suggest that GINS associates at replication forks with the MCM helicase that is responsible for unwinding the parental DNA duplex. Archaea also have an equivalent GINS complex that can interact with MCM and other replisome components. It seems likely that GINS couples MCM to other key proteins at forks, and we discuss here the current literature regarding this important late-comer to the DNA replication field.
Affiliation:
Cancer Research U.K., Paterson Institute for Cancer Research, University of Manchester, Manchester, UK. klabib@picr.man.ac.uk <klabib@picr.man.ac.uk>
Citation:
A key role for the GINS complex at DNA replication forks. 2007, 17 (6):271-8 Trends Cell Biol.
Journal:
Trends in Cell Biology
Issue Date:
Jun-2007
URI:
http://hdl.handle.net/10541/71279
DOI:
10.1016/j.tcb.2007.04.002
PubMed ID:
17467990
Type:
Article
Language:
en
ISSN:
1879-3088
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLabib, Karim-
dc.contributor.authorGambus, Agnieszka-
dc.date.accessioned2009-06-23T13:31:24Z-
dc.date.available2009-06-23T13:31:24Z-
dc.date.issued2007-06-
dc.identifier.citationA key role for the GINS complex at DNA replication forks. 2007, 17 (6):271-8 Trends Cell Biol.en
dc.identifier.issn1879-3088-
dc.identifier.pmid17467990-
dc.identifier.doi10.1016/j.tcb.2007.04.002-
dc.identifier.urihttp://hdl.handle.net/10541/71279-
dc.description.abstractThe GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome replication and also for the normal progression of DNA replication forks. Several recent studies suggest that GINS associates at replication forks with the MCM helicase that is responsible for unwinding the parental DNA duplex. Archaea also have an equivalent GINS complex that can interact with MCM and other replisome components. It seems likely that GINS couples MCM to other key proteins at forks, and we discuss here the current literature regarding this important late-comer to the DNA replication field.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshArchaeal Proteins-
dc.subject.meshChromosomal Proteins, Non-Histone-
dc.subject.meshDNA Helicases-
dc.subject.meshDNA Replication-
dc.subject.meshFungal Proteins-
dc.subject.meshHumans-
dc.subject.meshMacromolecular Substances-
dc.titleA key role for the GINS complex at DNA replication forksen
dc.typeArticleen
dc.contributor.departmentCancer Research U.K., Paterson Institute for Cancer Research, University of Manchester, Manchester, UK. klabib@picr.man.ac.uk <klabib@picr.man.ac.uk>en
dc.identifier.journalTrends in Cell Biologyen

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