Growth hormone replacement throughout life: Insights into age-related responses to treatment.

2.50
Hdl Handle:
http://hdl.handle.net/10541/71135
Title:
Growth hormone replacement throughout life: Insights into age-related responses to treatment.
Authors:
Clayton, Peter E; Gleeson, Helena K; Monson, John; Popovic, Vera; Shalet, Stephen M; Christiansen, J Sandahl
Abstract:
The adult growth hormone deficiency (GHD) syndrome is a well-defined clinical entity. Although the symptoms of GHD are not age specific, their relative importance differs depending on the patient's age, and the impact of GHD varies throughout adult life. Ceasing growth hormone (GH) therapy soon after final height in patients with severe GHD potentially limits somatic development by reducing accrual of bone and muscle mass. It is now recognized that the continuation of GH therapy in the transition years is required to achieve adult levels of somatic development. In middle age, the most worrying feature of GHD is the increase in cardiovascular risk, an important component of which is GHD-related dyslipidemia. One of the most profound effects of GH therapy in this age group is the durable reduction in cholesterol levels. Elderly GH-deficient patients experience the symptoms of GHD over and above the signs of normal aging. Perhaps most importantly, these patients have impaired quality of life, with fatigue as a major component. Evidence is growing for improved quality of life with GH therapy in the elderly. This review describes the diagnosis, symptoms and treatment of GHD specific to the different age groups.
Affiliation:
Endocrine Science Research Group, Division of Human Development, The Medical School, University of Manchester, UK.
Citation:
Growth hormone replacement throughout life: Insights into age-related responses to treatment. 2007, 17 (5):369-82 Growth Horm IGF Res.
Journal:
Growth Hormone & IGF Research
Issue Date:
Oct-2007
URI:
http://hdl.handle.net/10541/71135
DOI:
10.1016/j.ghir.2007.04.010
PubMed ID:
17560153
Type:
Article
Language:
en
ISSN:
1096-6374
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorClayton, Peter E-
dc.contributor.authorGleeson, Helena K-
dc.contributor.authorMonson, John-
dc.contributor.authorPopovic, Vera-
dc.contributor.authorShalet, Stephen M-
dc.contributor.authorChristiansen, J Sandahl-
dc.date.accessioned2009-06-22T11:54:50Z-
dc.date.available2009-06-22T11:54:50Z-
dc.date.issued2007-10-
dc.identifier.citationGrowth hormone replacement throughout life: Insights into age-related responses to treatment. 2007, 17 (5):369-82 Growth Horm IGF Res.en
dc.identifier.issn1096-6374-
dc.identifier.pmid17560153-
dc.identifier.doi10.1016/j.ghir.2007.04.010-
dc.identifier.urihttp://hdl.handle.net/10541/71135-
dc.description.abstractThe adult growth hormone deficiency (GHD) syndrome is a well-defined clinical entity. Although the symptoms of GHD are not age specific, their relative importance differs depending on the patient's age, and the impact of GHD varies throughout adult life. Ceasing growth hormone (GH) therapy soon after final height in patients with severe GHD potentially limits somatic development by reducing accrual of bone and muscle mass. It is now recognized that the continuation of GH therapy in the transition years is required to achieve adult levels of somatic development. In middle age, the most worrying feature of GHD is the increase in cardiovascular risk, an important component of which is GHD-related dyslipidemia. One of the most profound effects of GH therapy in this age group is the durable reduction in cholesterol levels. Elderly GH-deficient patients experience the symptoms of GHD over and above the signs of normal aging. Perhaps most importantly, these patients have impaired quality of life, with fatigue as a major component. Evidence is growing for improved quality of life with GH therapy in the elderly. This review describes the diagnosis, symptoms and treatment of GHD specific to the different age groups.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAging-
dc.subject.meshCardiovascular Diseases-
dc.subject.meshChild-
dc.subject.meshHormone Replacement Therapy-
dc.subject.meshHuman Growth Hormone-
dc.subject.meshHumans-
dc.subject.meshPuberty-
dc.titleGrowth hormone replacement throughout life: Insights into age-related responses to treatment.en
dc.typeArticleen
dc.contributor.departmentEndocrine Science Research Group, Division of Human Development, The Medical School, University of Manchester, UK.en
dc.identifier.journalGrowth Hormone & IGF Researchen

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