The impact of age and clinical factors on quality of life in early breast cancer: an analysis of 2208 women recruited to the UK START Trial (Standardisation of Breast Radiotherapy Trial).

2.50
Hdl Handle:
http://hdl.handle.net/10541/71122
Title:
The impact of age and clinical factors on quality of life in early breast cancer: an analysis of 2208 women recruited to the UK START Trial (Standardisation of Breast Radiotherapy Trial).
Authors:
Hopwood, Penelope; Haviland, Joanne; Mills, Judith; Sumo, Georges; Bliss, Judith M
Abstract:
Quality of life (QOL) assessments of women entering a UK randomised trial of adjuvant radiotherapy (START) were investigated to estimate the independent effects on QOL of age, time since surgery, type of breast surgery, chemotherapy and endocrine therapy. QOL was evaluated using the EORTC general cancer QOL scale (EORTC QLQ-C30), breast cancer module (BR23), the Body Image Scale (BIS) and the Hospital Anxiety and Depression Scale (HADS). Independent effects of age and clinical factors were tested using multiple regression analysis. A total of 2208 (mean age 56.9 years, range 26-87) consented to the QOL study prior to radiotherapy; 17.1% had undergone mastectomy (Mx) and the remainder had undergone a wide local excision (WLE). 33.3% had received adjuvant chemotherapy (CT) and 56.7% were taking endocrine therapy (ET). Age had significant effects on QOL with older and younger subgroups predicting poorer QOL for different domains. CT affected most QOL domains and resulted in worse body image, sexual functioning, breast and arm symptoms (<0.001). Mx was associated with greater body image concerns (p<0.001), and WLE with more arm symptoms (p=0.01). There were no effects of ET on QOL. Women <50 years (proxy pre-menopausal) had worse QOL in respect of anxiety, body image and breast symptoms but age and clinical factors had no effect on depression. Overall, QOL and mental health were favourable for most women about to start RT, but younger age and receiving CT were significant risk factors for poorer QOL, and so patients in these subgroups warrant further monitoring. Surgery had a limited impact and ET had no effect on QOL.
Affiliation:
Christie Hospital NHS Trust, Wilmslow road, Withington, Manchester M20 4BX, UK. penny.hopwood@christie-tr.nwest.nhs.uk <penny.hopwood@christie-tr.nwest.nhs.uk>
Citation:
The impact of age and clinical factors on quality of life in early breast cancer: an analysis of 2208 women recruited to the UK START Trial (Standardisation of Breast Radiotherapy Trial). 2007, 16 (3):241-51 Breast
Journal:
Breast
Issue Date:
Jun-2007
URI:
http://hdl.handle.net/10541/71122
DOI:
10.1016/j.breast.2006.11.003
PubMed ID:
17236771
Type:
Article
Language:
en
ISSN:
0960-9776
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHopwood, Penelope-
dc.contributor.authorHaviland, Joanne-
dc.contributor.authorMills, Judith-
dc.contributor.authorSumo, Georges-
dc.contributor.authorBliss, Judith M-
dc.date.accessioned2009-06-22T13:58:54Z-
dc.date.available2009-06-22T13:58:54Z-
dc.date.issued2007-06-
dc.identifier.citationThe impact of age and clinical factors on quality of life in early breast cancer: an analysis of 2208 women recruited to the UK START Trial (Standardisation of Breast Radiotherapy Trial). 2007, 16 (3):241-51 Breasten
dc.identifier.issn0960-9776-
dc.identifier.pmid17236771-
dc.identifier.doi10.1016/j.breast.2006.11.003-
dc.identifier.urihttp://hdl.handle.net/10541/71122-
dc.description.abstractQuality of life (QOL) assessments of women entering a UK randomised trial of adjuvant radiotherapy (START) were investigated to estimate the independent effects on QOL of age, time since surgery, type of breast surgery, chemotherapy and endocrine therapy. QOL was evaluated using the EORTC general cancer QOL scale (EORTC QLQ-C30), breast cancer module (BR23), the Body Image Scale (BIS) and the Hospital Anxiety and Depression Scale (HADS). Independent effects of age and clinical factors were tested using multiple regression analysis. A total of 2208 (mean age 56.9 years, range 26-87) consented to the QOL study prior to radiotherapy; 17.1% had undergone mastectomy (Mx) and the remainder had undergone a wide local excision (WLE). 33.3% had received adjuvant chemotherapy (CT) and 56.7% were taking endocrine therapy (ET). Age had significant effects on QOL with older and younger subgroups predicting poorer QOL for different domains. CT affected most QOL domains and resulted in worse body image, sexual functioning, breast and arm symptoms (<0.001). Mx was associated with greater body image concerns (p<0.001), and WLE with more arm symptoms (p=0.01). There were no effects of ET on QOL. Women <50 years (proxy pre-menopausal) had worse QOL in respect of anxiety, body image and breast symptoms but age and clinical factors had no effect on depression. Overall, QOL and mental health were favourable for most women about to start RT, but younger age and receiving CT were significant risk factors for poorer QOL, and so patients in these subgroups warrant further monitoring. Surgery had a limited impact and ET had no effect on QOL.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshActivities of Daily Living-
dc.subject.meshAdult-
dc.subject.meshAge Factors-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAnxiety-
dc.subject.meshBody Image-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshDepression-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMastectomy-
dc.subject.meshMiddle Aged-
dc.subject.meshQuality of Life-
dc.subject.meshRadiotherapy, Adjuvant-
dc.subject.meshRandomized Controlled Trials as Topic-
dc.subject.meshStress, Psychological-
dc.titleThe impact of age and clinical factors on quality of life in early breast cancer: an analysis of 2208 women recruited to the UK START Trial (Standardisation of Breast Radiotherapy Trial).en
dc.typeArticleen
dc.contributor.departmentChristie Hospital NHS Trust, Wilmslow road, Withington, Manchester M20 4BX, UK. penny.hopwood@christie-tr.nwest.nhs.uk <penny.hopwood@christie-tr.nwest.nhs.uk>en
dc.identifier.journalBreasten

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