Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation

2.50
Hdl Handle:
http://hdl.handle.net/10541/70469
Title:
Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation
Authors:
Raiber, Eun-Ang; Wilkinson, James A; Manetti, Fabrizio; Botta, Maurizio; Deakin, Jon A; Gallagher, John T; Lyon, Malcolm; Ducki, Sylvie W
Abstract:
The synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF).
Affiliation:
Centre for Molecular Drug Design, Cockcroft Building, University of Salford, Salford, UK.
Citation:
Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation. 2007, 17 (22):6321-5 Bioorg. Med. Chem. Lett.
Journal:
Bioorganic & Medicinal Chemistry Letters
Issue Date:
15-Nov-2007
URI:
http://hdl.handle.net/10541/70469
DOI:
10.1016/j.bmcl.2007.08.074
PubMed ID:
17870532
Type:
Article
Language:
en
ISSN:
0960-894X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorRaiber, Eun-Ang-
dc.contributor.authorWilkinson, James A-
dc.contributor.authorManetti, Fabrizio-
dc.contributor.authorBotta, Maurizio-
dc.contributor.authorDeakin, Jon A-
dc.contributor.authorGallagher, John T-
dc.contributor.authorLyon, Malcolm-
dc.contributor.authorDucki, Sylvie W-
dc.date.accessioned2009-06-15T12:22:12Z-
dc.date.available2009-06-15T12:22:12Z-
dc.date.issued2007-11-15-
dc.identifier.citationNovel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation. 2007, 17 (22):6321-5 Bioorg. Med. Chem. Lett.en
dc.identifier.issn0960-894X-
dc.identifier.pmid17870532-
dc.identifier.doi10.1016/j.bmcl.2007.08.074-
dc.identifier.urihttp://hdl.handle.net/10541/70469-
dc.description.abstractThe synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF).en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCell Line-
dc.subject.meshCell Movement-
dc.subject.meshComputer Simulation-
dc.subject.meshDogs-
dc.subject.meshHeparin-
dc.subject.meshHeparitin Sulfate-
dc.subject.meshHepatocyte Growth Factor-
dc.subject.meshModels, Molecular-
dc.subject.meshMolecular Mimicry-
dc.subject.meshMolecular Structure-
dc.subject.meshProto-Oncogene Proteins-
dc.subject.meshReceptors, Growth Factor-
dc.titleNovel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activationen
dc.typeArticleen
dc.contributor.departmentCentre for Molecular Drug Design, Cockcroft Building, University of Salford, Salford, UK.en
dc.identifier.journalBioorganic & Medicinal Chemistry Lettersen

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