Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells.

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Hdl Handle:
http://hdl.handle.net/10541/70464
Title:
Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells.
Authors:
Barraclough, Jane; Hodgkinson, Cassandra L; Hogg, Alison; Dive, Caroline ( 0000-0002-1726-8850 ) ; Welman, Arkadiusz
Abstract:
Increases in the levels and/or activity of nonreceptor tyrosine kinases c-Src and c-Yes are often associated with colorectal carcinogenesis. The physiological consequences of increased c-Yes activity during the early and late stages of tumorigenesis, in addition to the degree of redundancy between c-Yes and c-Src in colorectal cancer cells, remain elusive. To study the consequences of increases in c-Yes levels and activity in later stages of colorectal carcinogenesis, we developed human colorectal cancer cell lines in which c-Yes levels and activity can be inducibly increased by a tightly controlled expression of wild-type c-Yes or by constitutively active mutants of c-Yes, c-YesY537F, and c-Yes Delta t6aa. c-Yes induction resulted in increased cell motility but did not promote proliferation either in vitro or in vivo. These results suggest that in later stages of colorectal carcinogenesis, elevations in c-Yes levels/activity may promote cancer spread and metastasis rather than tumor growth.
Affiliation:
Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
Citation:
Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells. 2007, 9 (9):745-54 Neoplasia
Journal:
Neoplasia
Issue Date:
Sep-2007
URI:
http://hdl.handle.net/10541/70464
DOI:
10.1593/neo.07442
PubMed ID:
17898870
Type:
Article
Language:
en
ISSN:
1476-5586
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorBarraclough, Jane-
dc.contributor.authorHodgkinson, Cassandra L-
dc.contributor.authorHogg, Alison-
dc.contributor.authorDive, Caroline-
dc.contributor.authorWelman, Arkadiusz-
dc.date.accessioned2009-06-15T11:58:43Z-
dc.date.available2009-06-15T11:58:43Z-
dc.date.issued2007-09-
dc.identifier.citationIncreases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells. 2007, 9 (9):745-54 Neoplasiaen
dc.identifier.issn1476-5586-
dc.identifier.pmid17898870-
dc.identifier.doi10.1593/neo.07442-
dc.identifier.urihttp://hdl.handle.net/10541/70464-
dc.description.abstractIncreases in the levels and/or activity of nonreceptor tyrosine kinases c-Src and c-Yes are often associated with colorectal carcinogenesis. The physiological consequences of increased c-Yes activity during the early and late stages of tumorigenesis, in addition to the degree of redundancy between c-Yes and c-Src in colorectal cancer cells, remain elusive. To study the consequences of increases in c-Yes levels and activity in later stages of colorectal carcinogenesis, we developed human colorectal cancer cell lines in which c-Yes levels and activity can be inducibly increased by a tightly controlled expression of wild-type c-Yes or by constitutively active mutants of c-Yes, c-YesY537F, and c-Yes Delta t6aa. c-Yes induction resulted in increased cell motility but did not promote proliferation either in vitro or in vivo. These results suggest that in later stages of colorectal carcinogenesis, elevations in c-Yes levels/activity may promote cancer spread and metastasis rather than tumor growth.en
dc.language.isoenen
dc.subjectCell Line Tumouren
dc.subjectColorectal Canceren
dc.subjectCancer Proteinsen
dc.subjectCancer Transplantationen
dc.subject.meshAdenocarcinoma-
dc.subject.meshAnimals-
dc.subject.meshCell Adhesion-
dc.subject.meshCell Division-
dc.subject.meshCell Line, Tumor-
dc.subject.meshCell Movement-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshDoxycycline-
dc.subject.meshEnzyme Induction-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMice-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshNeoplasm Transplantation-
dc.subject.meshProto-Oncogene Proteins c-yes-
dc.subject.meshRecombinant Fusion Proteins-
dc.subject.meshsrc-Family Kinases-
dc.titleIncreases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.en
dc.identifier.journalNeoplasiaen

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