An annotation infrastructure for the analysis and interpretation of Affymetrix exon array data.

2.50
Hdl Handle:
http://hdl.handle.net/10541/70462
Title:
An annotation infrastructure for the analysis and interpretation of Affymetrix exon array data.
Authors:
Okoniewski, Michal J; Yates, Tim; Dibben, Sian; Miller, Crispin J
Abstract:
Affymetrix exon arrays contain probesets intended to target every known and predicted exon in the entire genome, posing significant challenges for high-throughput genome-wide data analysis. X:MAP http://xmap.picr.man.ac.uk, an annotation database, and exonmap http://www.bioconductor.org/packages/2.0/bioc/html/exonmap.html, a BioConductor/R package, are designed to support fine-grained analysis of exon array data. The system supports the application of standard statistical techniques, prior to the use of genome scale annotation to provide gene-, transcript- and exon-level summaries and visualization tools.
Affiliation:
Bioinformatics Group, Cancer Research UK, Paterson Institute for Cancer Research, The University of Manchester, Christie Hospital Site, Wilmslow Road, Manchester M20 4BX, UK. mokoniewski@picr.man.ac.uk
Citation:
An annotation infrastructure for the analysis and interpretation of Affymetrix exon array data. 2007, 8 (5):R79 Genome Biol.
Journal:
Genome Biology
Issue Date:
2007
URI:
http://hdl.handle.net/10541/70462
DOI:
10.1186/gb-2007-8-5-r79
PubMed ID:
17498294
Type:
Article
Language:
en
ISSN:
1465-6914
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorOkoniewski, Michal J-
dc.contributor.authorYates, Tim-
dc.contributor.authorDibben, Sian-
dc.contributor.authorMiller, Crispin J-
dc.date.accessioned2009-06-15T11:49:20Z-
dc.date.available2009-06-15T11:49:20Z-
dc.date.issued2007-
dc.identifier.citationAn annotation infrastructure for the analysis and interpretation of Affymetrix exon array data. 2007, 8 (5):R79 Genome Biol.en
dc.identifier.issn1465-6914-
dc.identifier.pmid17498294-
dc.identifier.doi10.1186/gb-2007-8-5-r79-
dc.identifier.urihttp://hdl.handle.net/10541/70462-
dc.description.abstractAffymetrix exon arrays contain probesets intended to target every known and predicted exon in the entire genome, posing significant challenges for high-throughput genome-wide data analysis. X:MAP http://xmap.picr.man.ac.uk, an annotation database, and exonmap http://www.bioconductor.org/packages/2.0/bioc/html/exonmap.html, a BioConductor/R package, are designed to support fine-grained analysis of exon array data. The system supports the application of standard statistical techniques, prior to the use of genome scale annotation to provide gene-, transcript- and exon-level summaries and visualization tools.en
dc.language.isoenen
dc.subject.meshComputer Graphics-
dc.subject.meshDNA Probes-
dc.subject.meshDatabases, Nucleic Acid-
dc.subject.meshExons-
dc.subject.meshGenome, Human-
dc.subject.meshHumans-
dc.subject.meshModels, Statistical-
dc.subject.meshSoftware-
dc.titleAn annotation infrastructure for the analysis and interpretation of Affymetrix exon array data.en
dc.typeArticleen
dc.contributor.departmentBioinformatics Group, Cancer Research UK, Paterson Institute for Cancer Research, The University of Manchester, Christie Hospital Site, Wilmslow Road, Manchester M20 4BX, UK. mokoniewski@picr.man.ac.uken
dc.identifier.journalGenome Biologyen
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