2.50
Hdl Handle:
http://hdl.handle.net/10541/70329
Title:
How will haematologists use proteomics?
Authors:
Unwin, Richard D; Whetton, Anthony D
Abstract:
Proteomics technologies are emerging as a useful tool in the identification of disease biomarkers, and in defining and characterising both normal physiological and disease processes. Many cellular changes in protein expression in response to an external stimulus or mutation can only be characterised at the proteome level. In these cases protein expression is often controlled by altered rates of translation and/or degradation, making proteomics an important tool in the analysis of biological systems. In the leukaemias, post-translational modification of proteins (e.g. phosphorylation, acetylation) plays a key role in the molecular pathology of the disease: such modifications can now be detected with novel proteomic methods. In a clinical setting, serum remains a relatively un-mined source of information for prognosis and response to therapy. This protein rich fluid represents an opportunity for proteomics research to benefit hematologists and others. In this review, we discuss the technologies available for the study of the proteome that offer realistic opportunities in haematology.
Affiliation:
Stem Cell and Leukaemia Proteomics Laboratory, Faculty of Medical and Human Sciences, University of Manchester, Christie Hospital, Kinnaird House, Kinnaird Road, Withington, Manchester, UK M20 4QL. runwin@manchester.ac.uk
Citation:
How will haematologists use proteomics? 2007, 21 (6):315-26 Blood Rev.
Journal:
Blood Reviews
Issue Date:
Nov-2007
URI:
http://hdl.handle.net/10541/70329
DOI:
10.1016/j.blre.2007.07.002
PubMed ID:
17889973
Type:
Article
Language:
en
ISSN:
0268-960X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorUnwin, Richard D-
dc.contributor.authorWhetton, Anthony D-
dc.date.accessioned2009-06-12T14:13:23Z-
dc.date.available2009-06-12T14:13:23Z-
dc.date.issued2007-11-
dc.identifier.citationHow will haematologists use proteomics? 2007, 21 (6):315-26 Blood Rev.en
dc.identifier.issn0268-960X-
dc.identifier.pmid17889973-
dc.identifier.doi10.1016/j.blre.2007.07.002-
dc.identifier.urihttp://hdl.handle.net/10541/70329-
dc.description.abstractProteomics technologies are emerging as a useful tool in the identification of disease biomarkers, and in defining and characterising both normal physiological and disease processes. Many cellular changes in protein expression in response to an external stimulus or mutation can only be characterised at the proteome level. In these cases protein expression is often controlled by altered rates of translation and/or degradation, making proteomics an important tool in the analysis of biological systems. In the leukaemias, post-translational modification of proteins (e.g. phosphorylation, acetylation) plays a key role in the molecular pathology of the disease: such modifications can now be detected with novel proteomic methods. In a clinical setting, serum remains a relatively un-mined source of information for prognosis and response to therapy. This protein rich fluid represents an opportunity for proteomics research to benefit hematologists and others. In this review, we discuss the technologies available for the study of the proteome that offer realistic opportunities in haematology.en
dc.language.isoenen
dc.subjectHaematologyen
dc.subjectLeukaemiaen
dc.subject.meshBiological Markers-
dc.subject.meshHematology-
dc.subject.meshHumans-
dc.subject.meshLeukemia-
dc.subject.meshProteomics-
dc.titleHow will haematologists use proteomics?en
dc.typeArticleen
dc.contributor.departmentStem Cell and Leukaemia Proteomics Laboratory, Faculty of Medical and Human Sciences, University of Manchester, Christie Hospital, Kinnaird House, Kinnaird Road, Withington, Manchester, UK M20 4QL. runwin@manchester.ac.uken
dc.identifier.journalBlood Reviewsen

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