Adult weight gain and central obesity in women with and without a family history of breast cancer: a case control study.

2.50
Hdl Handle:
http://hdl.handle.net/10541/70313
Title:
Adult weight gain and central obesity in women with and without a family history of breast cancer: a case control study.
Authors:
Harvie, Michelle N; Bokhari, Saba; Shenton, Andrew; Ashcroft, Linda; Evans, D Gareth R; Swindell, Ric; Howell, Anthony ( 0000-0002-3879-5991 )
Abstract:
Adult weight gain and central obesity can increase breast cancer risk. We determined the prevalence of adult weight gain and central obesity amongst women with a family history (FH) as compared to women with a population risk to determine whether adiposity could contribute to their increased risk. Adult weight gain, waist and waist:hip ratio (WHR) were determined amongst 475 women (aged 20-60 years) attending a regional FH breast cancer risk clinic, compared to 312 age matched women at population risk. Patterns of adult weight gain did not differ between women with and without a FH of breast cancer. The majority of weight gain occurred between the ages of 20 and 40 in both groups. Mean (sd) weight gain for women aged >40 years with a FH was 8.9 (10.3) kg compared to 9.1 (10.6) kg for controls (p = 0.85). Women with a FH had a significantly greater waist and WHR than controls. Mean (sd) waist was 83.7 (13) cm compared to 81.6 (11.3) cm for controls (p < 0.01). Mean (sd) WHR was 0.82 (0.1) compared to 0.80 (0.1) for controls (p < 0.01). FH of breast cancer was an independent predictor of having a WHR of >0.85; odds ratio (95% CI) = 1.42 (1.01-2.01) (p = 0.044). Significant weight gain between the ages of 20 and 40 and the prevalence of central obesity amongst FH women suggest the need for weight management within FH clinics.
Affiliation:
Breast Cancer Prevention Centre, South Manchester University Hospitals NHS Trust, Manchester M20 2LR, UK. Maria.Parker@christie-tr.nwest.nhs.uk
Citation:
Adult weight gain and central obesity in women with and without a family history of breast cancer: a case control study. 2007, 6 (3):287-94 Fam. Cancer
Journal:
Familial Cancer
Issue Date:
2007
URI:
http://hdl.handle.net/10541/70313
DOI:
10.1007/s10689-007-9122-3
PubMed ID:
17429760
Type:
Article
Language:
en
ISSN:
1389-9600
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHarvie, Michelle N-
dc.contributor.authorBokhari, Saba-
dc.contributor.authorShenton, Andrew-
dc.contributor.authorAshcroft, Linda-
dc.contributor.authorEvans, D Gareth R-
dc.contributor.authorSwindell, Ric-
dc.contributor.authorHowell, Anthony-
dc.date.accessioned2009-06-12T11:26:52Z-
dc.date.available2009-06-12T11:26:52Z-
dc.date.issued2007-
dc.identifier.citationAdult weight gain and central obesity in women with and without a family history of breast cancer: a case control study. 2007, 6 (3):287-94 Fam. Canceren
dc.identifier.issn1389-9600-
dc.identifier.pmid17429760-
dc.identifier.doi10.1007/s10689-007-9122-3-
dc.identifier.urihttp://hdl.handle.net/10541/70313-
dc.description.abstractAdult weight gain and central obesity can increase breast cancer risk. We determined the prevalence of adult weight gain and central obesity amongst women with a family history (FH) as compared to women with a population risk to determine whether adiposity could contribute to their increased risk. Adult weight gain, waist and waist:hip ratio (WHR) were determined amongst 475 women (aged 20-60 years) attending a regional FH breast cancer risk clinic, compared to 312 age matched women at population risk. Patterns of adult weight gain did not differ between women with and without a FH of breast cancer. The majority of weight gain occurred between the ages of 20 and 40 in both groups. Mean (sd) weight gain for women aged >40 years with a FH was 8.9 (10.3) kg compared to 9.1 (10.6) kg for controls (p = 0.85). Women with a FH had a significantly greater waist and WHR than controls. Mean (sd) waist was 83.7 (13) cm compared to 81.6 (11.3) cm for controls (p < 0.01). Mean (sd) WHR was 0.82 (0.1) compared to 0.80 (0.1) for controls (p < 0.01). FH of breast cancer was an independent predictor of having a WHR of >0.85; odds ratio (95% CI) = 1.42 (1.01-2.01) (p = 0.044). Significant weight gain between the ages of 20 and 40 and the prevalence of central obesity amongst FH women suggest the need for weight management within FH clinics.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshAdult-
dc.subject.meshBody Composition-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCase-Control Studies-
dc.subject.meshComorbidity-
dc.subject.meshFemale-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGreat Britain-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshObesity-
dc.subject.meshPrevalence-
dc.subject.meshRisk Factors-
dc.subject.meshWeight Gain-
dc.titleAdult weight gain and central obesity in women with and without a family history of breast cancer: a case control study.en
dc.typeArticleen
dc.contributor.departmentBreast Cancer Prevention Centre, South Manchester University Hospitals NHS Trust, Manchester M20 2LR, UK. Maria.Parker@christie-tr.nwest.nhs.uken
dc.identifier.journalFamilial Canceren

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