Distortion-corrected T2 weighted MRI: a novel approach to prostate radiotherapy planning.

2.50
Hdl Handle:
http://hdl.handle.net/10541/70296
Title:
Distortion-corrected T2 weighted MRI: a novel approach to prostate radiotherapy planning.
Authors:
Jackson, Andrew; Reinsberg, S A; Sohaib, S A; Charles-Edwards, E M; Mangar, Stephen A; South, C P; Leach, Martin O; Dearnaley, David P
Abstract:
The purpose of this study was to evaluate distortion-corrected MRI as a radiotherapy planning tool for prostate cancer and the resultant implications for dose sparing of organs at risk. 11 men who were to be treated with radical conformal radiotherapy for localized prostate cancer had an MRI scan under radiotherapy planning conditions, which was corrected for geometric distortion. Radiotherapy plans were created for planning target volumes derived from the MRI- and CT-defined prostate. Dose volume histograms were produced for the rectum, bladder and penile bulb. The mean volume of the prostate as defined on CT and MRI was 41 cm3 and 36 cm3, respectively (p = 0.009). The predicted percentage of the rectum treated to dose levels of 45-65 Gy was significantly lower for plans delineating the prostate with MRI than for those with CT. The rectal-sparing effect was confined to the lowermost 4 cm of the rectum (anal canal). There were no differences between the predicted doses to bladder or penile bulb (as defined using MRI) between plans. In conclusion, prostate radiotherapy planning based on distortion-corrected MRI is feasible and results in a smaller target volume than does CT. This leads to a lower predicted proportion of the rectum, in particular the lower rectum (anal canal), treated to a given dose than with CT.
Affiliation:
Academic Department of Radiotherapy and Oncology, Royal Marsden Hospital and Institute of Cancer Research, Downs Rd, Sutton SM2 5PT, UK. Andrew.Jackson@manchester.ac.uk
Citation:
Distortion-corrected T2 weighted MRI: a novel approach to prostate radiotherapy planning. 2007, 80 (959):926-33 Br J Radiol
Journal:
The British Journal of Radiology
Issue Date:
Nov-2007
URI:
http://hdl.handle.net/10541/70296
DOI:
10.1259/bjr/51363812
PubMed ID:
17908816
Type:
Article
Language:
en
ISSN:
1748-880X
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorJackson, Andrew-
dc.contributor.authorReinsberg, S A-
dc.contributor.authorSohaib, S A-
dc.contributor.authorCharles-Edwards, E M-
dc.contributor.authorMangar, Stephen A-
dc.contributor.authorSouth, C P-
dc.contributor.authorLeach, Martin O-
dc.contributor.authorDearnaley, David P-
dc.date.accessioned2009-06-12T10:59:53Z-
dc.date.available2009-06-12T10:59:53Z-
dc.date.issued2007-11-
dc.identifier.citationDistortion-corrected T2 weighted MRI: a novel approach to prostate radiotherapy planning. 2007, 80 (959):926-33 Br J Radiolen
dc.identifier.issn1748-880X-
dc.identifier.pmid17908816-
dc.identifier.doi10.1259/bjr/51363812-
dc.identifier.urihttp://hdl.handle.net/10541/70296-
dc.description.abstractThe purpose of this study was to evaluate distortion-corrected MRI as a radiotherapy planning tool for prostate cancer and the resultant implications for dose sparing of organs at risk. 11 men who were to be treated with radical conformal radiotherapy for localized prostate cancer had an MRI scan under radiotherapy planning conditions, which was corrected for geometric distortion. Radiotherapy plans were created for planning target volumes derived from the MRI- and CT-defined prostate. Dose volume histograms were produced for the rectum, bladder and penile bulb. The mean volume of the prostate as defined on CT and MRI was 41 cm3 and 36 cm3, respectively (p = 0.009). The predicted percentage of the rectum treated to dose levels of 45-65 Gy was significantly lower for plans delineating the prostate with MRI than for those with CT. The rectal-sparing effect was confined to the lowermost 4 cm of the rectum (anal canal). There were no differences between the predicted doses to bladder or penile bulb (as defined using MRI) between plans. In conclusion, prostate radiotherapy planning based on distortion-corrected MRI is feasible and results in a smaller target volume than does CT. This leads to a lower predicted proportion of the rectum, in particular the lower rectum (anal canal), treated to a given dose than with CT.en
dc.language.isoenen
dc.subjectProstate Canceren
dc.subject.meshAged-
dc.subject.meshHumans-
dc.subject.meshImage Enhancement-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshProstatic Neoplasms-
dc.subject.meshRadiotherapy Dosage-
dc.subject.meshRadiotherapy Planning, Computer-Assisted-
dc.subject.meshRadiotherapy, Conformal-
dc.subject.meshTomography, X-Ray Computed-
dc.titleDistortion-corrected T2 weighted MRI: a novel approach to prostate radiotherapy planning.en
dc.typeArticleen
dc.contributor.departmentAcademic Department of Radiotherapy and Oncology, Royal Marsden Hospital and Institute of Cancer Research, Downs Rd, Sutton SM2 5PT, UK. Andrew.Jackson@manchester.ac.uken
dc.identifier.journalThe British Journal of Radiologyen

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