2.50
Hdl Handle:
http://hdl.handle.net/10541/70240
Title:
The genomics revolution and radiotherapy
Authors:
West, Catharine M L; Elliott, Rebecca M; Burnet, N G
Abstract:
The expansion of our knowledge through the Human Genome Project has been accompanied by the development of new high-throughput techniques, which provide extensive capabilities for the analysis of a large number of genes or the whole genome. These assays can be carried out in various clinical samples at the DNA (genome), RNA (transcriptome) or protein (proteome) level. There is a belief that this genomic revolution, i.e. sequencing of the human genome and developments in high-throughput technology, heralds a future of personalised medicine. For clinical oncology, this progress should increase the possibility of predicting individual patient responses to radiotherapy. This review highlights some of the work involving sparsely ionising radiation and the new technologies.
Affiliation:
Academic Radiation Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester M20 4BX, UK. catharine.west@manchester.ac.uk
Citation:
The genomics revolution and radiotherapy. 2007, 19 (6):470-80 Clin Oncol
Journal:
Clinical Oncology
Issue Date:
Aug-2007
URI:
http://hdl.handle.net/10541/70240
DOI:
10.1016/j.clon.2007.02.016
PubMed ID:
17419040
Type:
Article
Language:
en
ISSN:
0936-6555
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorWest, Catharine M L-
dc.contributor.authorElliott, Rebecca M-
dc.contributor.authorBurnet, N G-
dc.date.accessioned2009-06-11T16:13:13Z-
dc.date.available2009-06-11T16:13:13Z-
dc.date.issued2007-08-
dc.identifier.citationThe genomics revolution and radiotherapy. 2007, 19 (6):470-80 Clin Oncolen
dc.identifier.issn0936-6555-
dc.identifier.pmid17419040-
dc.identifier.doi10.1016/j.clon.2007.02.016-
dc.identifier.urihttp://hdl.handle.net/10541/70240-
dc.description.abstractThe expansion of our knowledge through the Human Genome Project has been accompanied by the development of new high-throughput techniques, which provide extensive capabilities for the analysis of a large number of genes or the whole genome. These assays can be carried out in various clinical samples at the DNA (genome), RNA (transcriptome) or protein (proteome) level. There is a belief that this genomic revolution, i.e. sequencing of the human genome and developments in high-throughput technology, heralds a future of personalised medicine. For clinical oncology, this progress should increase the possibility of predicting individual patient responses to radiotherapy. This review highlights some of the work involving sparsely ionising radiation and the new technologies.en
dc.language.isoenen
dc.subjectCanceren
dc.subjectRadiotherapyen
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshGenomics-
dc.subject.meshGenotype-
dc.subject.meshHuman Genome Project-
dc.subject.meshHumans-
dc.subject.meshNeoplasms-
dc.subject.meshOligonucleotide Array Sequence Analysis-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshRadiation Tolerance-
dc.subject.meshTranscription, Genetic-
dc.titleThe genomics revolution and radiotherapyen
dc.typeArticleen
dc.contributor.departmentAcademic Radiation Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester M20 4BX, UK. catharine.west@manchester.ac.uken
dc.identifier.journalClinical Oncologyen

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