Salvaging locoregional recurrence with radiotherapy after surgery in early cervical cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10541/70225
Title:
Salvaging locoregional recurrence with radiotherapy after surgery in early cervical cancer.
Authors:
Jain, Pooja; Hunter, Robin D; Livsey, Jacqueline E; Coyle, C A; Swindell, Ric; Davidson, Susan E
Abstract:
AIMS: To determine the outcome and morbidity after radiotherapy for locally recurrent cervical cancer. MATERIALS AND METHODS: Women who presented with locally recurrent cervical cancer after surgery alone during 1985 and 1997 were identified from the hospital database. Data were collected and analysed to include the stage at first diagnosis, staging investigations before surgery, the surgical procedure, the indication for radiotherapy, the type of radiotherapy, morbidity and survival. RESULTS: In total, 130 women had radical external beam radiotherapy and/or intracavitary brachytherapy for locoregional recurrence during the defined study period. The 5-year disease-specific survival for the study population was 40.2%. Women who were treated for vault recurrence had a significantly better 5-year disease-free survival compared with women who developed nodal recurrence alone (55.4% vs 12.5%). This group of women also had a significantly slower rate of disease progression after radiotherapy than women with nodal recurrence (48.7% vs 87.5%, P=0.0001). CONCLUSION: Radical radiotherapy alone is able to salvage 55% of vaginal vault recurrences after surgery for cervical cancer with minimal late toxicity. Salvage rates in women with pelvic nodal recurrences are considerably lower. Chemoradiotherapy using intensity-modulated radiotherapy to deliver an escalated radiotherapy dose needs to be pursued to improve locoregional control.
Affiliation:
Clinical Oncology, Christie Hospital NHS Trust, Manchester, UK. pooja.jain@christie.nhs.uk
Citation:
Salvaging locoregional recurrence with radiotherapy after surgery in early cervical cancer. 2007, 19 (10):763-8 Clin Oncol
Journal:
Clinical Oncology
Issue Date:
Dec-2007
URI:
http://hdl.handle.net/10541/70225
DOI:
10.1016/j.clon.2007.08.015
PubMed ID:
17931845
Type:
Article
Language:
en
ISSN:
0936-6555
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorJain, Pooja-
dc.contributor.authorHunter, Robin D-
dc.contributor.authorLivsey, Jacqueline E-
dc.contributor.authorCoyle, C A-
dc.contributor.authorSwindell, Ric-
dc.contributor.authorDavidson, Susan E-
dc.date.accessioned2009-06-11T14:19:12Z-
dc.date.available2009-06-11T14:19:12Z-
dc.date.issued2007-12-
dc.identifier.citationSalvaging locoregional recurrence with radiotherapy after surgery in early cervical cancer. 2007, 19 (10):763-8 Clin Oncolen
dc.identifier.issn0936-6555-
dc.identifier.pmid17931845-
dc.identifier.doi10.1016/j.clon.2007.08.015-
dc.identifier.urihttp://hdl.handle.net/10541/70225-
dc.description.abstractAIMS: To determine the outcome and morbidity after radiotherapy for locally recurrent cervical cancer. MATERIALS AND METHODS: Women who presented with locally recurrent cervical cancer after surgery alone during 1985 and 1997 were identified from the hospital database. Data were collected and analysed to include the stage at first diagnosis, staging investigations before surgery, the surgical procedure, the indication for radiotherapy, the type of radiotherapy, morbidity and survival. RESULTS: In total, 130 women had radical external beam radiotherapy and/or intracavitary brachytherapy for locoregional recurrence during the defined study period. The 5-year disease-specific survival for the study population was 40.2%. Women who were treated for vault recurrence had a significantly better 5-year disease-free survival compared with women who developed nodal recurrence alone (55.4% vs 12.5%). This group of women also had a significantly slower rate of disease progression after radiotherapy than women with nodal recurrence (48.7% vs 87.5%, P=0.0001). CONCLUSION: Radical radiotherapy alone is able to salvage 55% of vaginal vault recurrences after surgery for cervical cancer with minimal late toxicity. Salvage rates in women with pelvic nodal recurrences are considerably lower. Chemoradiotherapy using intensity-modulated radiotherapy to deliver an escalated radiotherapy dose needs to be pursued to improve locoregional control.en
dc.language.isoenen
dc.subjectCancer Recurrenceen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBrachytherapy-
dc.subject.meshDisease-Free Survival-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshHysterectomy-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshRetrospective Studies-
dc.subject.meshSalvage Therapy-
dc.subject.meshTreatment Outcome-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleSalvaging locoregional recurrence with radiotherapy after surgery in early cervical cancer.en
dc.typeArticleen
dc.contributor.departmentClinical Oncology, Christie Hospital NHS Trust, Manchester, UK. pooja.jain@christie.nhs.uken
dc.identifier.journalClinical Oncologyen

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