Role of colony stimulating factors (CSFs) in solid tumours: results of an expert panel

2.50
Hdl Handle:
http://hdl.handle.net/10541/70224
Title:
Role of colony stimulating factors (CSFs) in solid tumours: results of an expert panel
Authors:
Gridelli, Cesare; Aapro, Matti S; Barni, Sandro; Beretta, Giordano Domenico; Colucci, Giuseppe; Daniele, Bruno; Del Mastro, Lucia; Di Maio, Massimo; De Petris, Luigi; Perrone, Francesco; Thatcher, Nick; De Marinis, Filippo
Abstract:
Febrile neutropenia is a relatively frequent event in cancer patients treated with chemotherapy. A relevant body of scientific evidence has been produced in the last 2 decades, through clinical trials addressing the efficacy of colony stimulating factors (CSFs) in the prevention and treatment of febrile neutropenia. The correct use of CSFs needs to be optimized, and several guidelines have been produced and periodically updated, in order to uniform and guide clinical practice. The aim of this review is to synthesize the most relevant clinical trials and the most important existing guidelines about the role of CSFs in solid tumours. Role of CSFs as primary prophylaxis, secondary prophylaxis and treatment of afebrile and febrile neutropenia is discussed. A special focus is dedicated to neutropenia and the use of CSFs in the treatment of the three "big killers" among the solid tumours: breast cancer, lung cancer and colorectal cancer.
Affiliation:
Division of Medical Oncology, S.G. Moscati Hospital, Contrada Amoretta, 83100 Avellino, Italy. cgridelli@libero.it
Citation:
Role of colony stimulating factors (CSFs) in solid tumours: results of an expert panel. 2007, 63 (1):53-64 Crit. Rev. Oncol. Hematol.
Journal:
Critical Reviews in Oncology/Hematology
Issue Date:
Jul-2007
URI:
http://hdl.handle.net/10541/70224
DOI:
10.1016/j.critrevonc.2007.01.008
PubMed ID:
17368037
Type:
Article
Language:
en
ISSN:
1040-8428
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorGridelli, Cesare-
dc.contributor.authorAapro, Matti S-
dc.contributor.authorBarni, Sandro-
dc.contributor.authorBeretta, Giordano Domenico-
dc.contributor.authorColucci, Giuseppe-
dc.contributor.authorDaniele, Bruno-
dc.contributor.authorDel Mastro, Lucia-
dc.contributor.authorDi Maio, Massimo-
dc.contributor.authorDe Petris, Luigi-
dc.contributor.authorPerrone, Francesco-
dc.contributor.authorThatcher, Nick-
dc.contributor.authorDe Marinis, Filippo-
dc.date.accessioned2009-06-11T14:16:01Z-
dc.date.available2009-06-11T14:16:01Z-
dc.date.issued2007-07-
dc.identifier.citationRole of colony stimulating factors (CSFs) in solid tumours: results of an expert panel. 2007, 63 (1):53-64 Crit. Rev. Oncol. Hematol.en
dc.identifier.issn1040-8428-
dc.identifier.pmid17368037-
dc.identifier.doi10.1016/j.critrevonc.2007.01.008-
dc.identifier.urihttp://hdl.handle.net/10541/70224-
dc.description.abstractFebrile neutropenia is a relatively frequent event in cancer patients treated with chemotherapy. A relevant body of scientific evidence has been produced in the last 2 decades, through clinical trials addressing the efficacy of colony stimulating factors (CSFs) in the prevention and treatment of febrile neutropenia. The correct use of CSFs needs to be optimized, and several guidelines have been produced and periodically updated, in order to uniform and guide clinical practice. The aim of this review is to synthesize the most relevant clinical trials and the most important existing guidelines about the role of CSFs in solid tumours. Role of CSFs as primary prophylaxis, secondary prophylaxis and treatment of afebrile and febrile neutropenia is discussed. A special focus is dedicated to neutropenia and the use of CSFs in the treatment of the three "big killers" among the solid tumours: breast cancer, lung cancer and colorectal cancer.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectColorectal Canceren
dc.subjectLung Canceren
dc.subject.meshAntineoplastic Agents-
dc.subject.meshBreast Neoplasms-
dc.subject.meshClinical Trials as Topic-
dc.subject.meshColony-Stimulating Factors-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshFemale-
dc.subject.meshFever-
dc.subject.meshFilgrastim-
dc.subject.meshHumans-
dc.subject.meshLung Neoplasms-
dc.subject.meshMale-
dc.subject.meshNeutropenia-
dc.subject.meshPractice Guidelines as Topic-
dc.titleRole of colony stimulating factors (CSFs) in solid tumours: results of an expert panelen
dc.typeArticleen
dc.contributor.departmentDivision of Medical Oncology, S.G. Moscati Hospital, Contrada Amoretta, 83100 Avellino, Italy. cgridelli@libero.iten
dc.identifier.journalCritical Reviews in Oncology/Hematologyen

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