2.50
Hdl Handle:
http://hdl.handle.net/10541/70214
Title:
Aluminium in human breast tissue.
Authors:
Exley, Christopher; Charles, Lisa M; Barr, Lester; Martin, Claire; Polwart, Anthony; Darbre, Philippa D
Abstract:
Aluminium is omnipresent in everyday life and increased exposure is resulting in a burgeoning body burden of this non-essential metal. Personal care products are potential contributors to the body burden of aluminium and recent evidence has linked breast cancer with aluminium-based antiperspirants. We have used graphite furnace atomic absorption spectrometry (GFAAS) to measure the aluminium content in breast biopsies obtained following mastectomies. The aluminium content of breast tissue and breast tissue fat were in the range 4-437 nmol/g dry wt. and 3-192 nmol/g oil, respectively. The aluminium content of breast tissue in the outer regions (axilla and lateral) was significantly higher (P=0.033) than the inner regions (middle and medial) of the breast. Whether differences in the regional distribution of aluminium in the breast are related to the known higher incidence of tumours in the outer upper quadrant of the breast remains to be ascertained.
Affiliation:
Birchall Centre for Inorganic Chemistry and Materials Science, Lennard-Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK. c.exley@chem.keele.ac.uk
Citation:
Aluminium in human breast tissue. 2007, 101 (9):1344-6 J. Inorg. Biochem.
Journal:
Journal of Inorganic Biochemistry
Issue Date:
6-Jun-2007
URI:
http://hdl.handle.net/10541/70214
DOI:
10.1016/j.jinorgbio.2007.06.005
PubMed ID:
17629949
Type:
Article
Language:
en
ISSN:
0162-0134
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorExley, Christopher-
dc.contributor.authorCharles, Lisa M-
dc.contributor.authorBarr, Lester-
dc.contributor.authorMartin, Claire-
dc.contributor.authorPolwart, Anthony-
dc.contributor.authorDarbre, Philippa D-
dc.date.accessioned2009-06-11T13:14:01Z-
dc.date.available2009-06-11T13:14:01Z-
dc.date.issued2007-06-06-
dc.identifier.citationAluminium in human breast tissue. 2007, 101 (9):1344-6 J. Inorg. Biochem.en
dc.identifier.issn0162-0134-
dc.identifier.pmid17629949-
dc.identifier.doi10.1016/j.jinorgbio.2007.06.005-
dc.identifier.urihttp://hdl.handle.net/10541/70214-
dc.description.abstractAluminium is omnipresent in everyday life and increased exposure is resulting in a burgeoning body burden of this non-essential metal. Personal care products are potential contributors to the body burden of aluminium and recent evidence has linked breast cancer with aluminium-based antiperspirants. We have used graphite furnace atomic absorption spectrometry (GFAAS) to measure the aluminium content in breast biopsies obtained following mastectomies. The aluminium content of breast tissue and breast tissue fat were in the range 4-437 nmol/g dry wt. and 3-192 nmol/g oil, respectively. The aluminium content of breast tissue in the outer regions (axilla and lateral) was significantly higher (P=0.033) than the inner regions (middle and medial) of the breast. Whether differences in the regional distribution of aluminium in the breast are related to the known higher incidence of tumours in the outer upper quadrant of the breast remains to be ascertained.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectBreast Faten
dc.subjectBreast Tissueen
dc.subjectAnitperspiranten
dc.subject.meshAluminum-
dc.subject.meshBiopsy-
dc.subject.meshBody Burden-
dc.subject.meshBreast-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshSpectrophotometry, Atomic-
dc.titleAluminium in human breast tissue.en
dc.typeArticleen
dc.contributor.departmentBirchall Centre for Inorganic Chemistry and Materials Science, Lennard-Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK. c.exley@chem.keele.ac.uken
dc.identifier.journalJournal of Inorganic Biochemistryen

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