2.50
Hdl Handle:
http://hdl.handle.net/10541/70177
Title:
Allergy and risk of childhood leukaemia: results from the UKCCS.
Authors:
Hughes, Ann M; Lightfoot, Tracy; Simpson, Jill; Ansell, Pat; McKinney, Patricia A; Kinsey, Sally E; Mitchell, Christopher D; Eden, Tim O B; Greaves, Mel F; Roman, Eve
Abstract:
We investigated the relationship between childhood leukaemia and preceding history of allergy. A nationwide case-control study of childhood cancers was conducted in the United Kingdom with population-based sampling of cases (n = 839) and controls (n = 1,337), matched on age, sex and region of residence. Information about clinically diagnosed allergies was obtained from primary care records. More than a third of subjects had at least one allergy diagnosed prior to leukaemia diagnosis (cases) or pseudo-diagnosis (controls). For both total acute lymphoblastic leukaemia (ALL) and common-ALL/precursor B-cell ALL (c-ALL), a history of eczema was associated with a 30% significant reduction in risk: the odds ratios (OR) and 95% confidence intervals (CI) were 0.70 (0.51-0.97) and 0.68 (0.48-0.98), respectively. Similar associations were observed for hayfever (OR = 0.47; 95% CI: 0.26-0.85 and OR = 0.62; 95% CI: 0.33-1.16 for ALL and c-ALL, respectively). No such patterns were seen either for asthma and ALL, or for any allergy and acute myeloid leukaemia. A comparative analysis of primary care records with parents recall of allergy revealed only moderate agreement with contemporaneous clinical diagnoses for both cases and controls--confirming the unreliability of parental report at interview. Our finding of a reciprocal relationship between allergy and ALL in children is compatible with the hypothesis that a dysregulated immune response is a critical determinant of childhood ALL.
Affiliation:
Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, United Kingdom.
Citation:
Allergy and risk of childhood leukaemia: results from the UKCCS. 2007, 121 (4):819-24 Int. J. Cancer
Journal:
International Journal of Cancer
Issue Date:
15-Aug-2007
URI:
http://hdl.handle.net/10541/70177
DOI:
10.1002/ijc.22702
PubMed ID:
17390373
Type:
Article
Language:
en
ISSN:
0020-7136
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHughes, Ann M-
dc.contributor.authorLightfoot, Tracy-
dc.contributor.authorSimpson, Jill-
dc.contributor.authorAnsell, Pat-
dc.contributor.authorMcKinney, Patricia A-
dc.contributor.authorKinsey, Sally E-
dc.contributor.authorMitchell, Christopher D-
dc.contributor.authorEden, Tim O B-
dc.contributor.authorGreaves, Mel F-
dc.contributor.authorRoman, Eve-
dc.date.accessioned2009-06-11T11:27:00Z-
dc.date.available2009-06-11T11:27:00Z-
dc.date.issued2007-08-15-
dc.identifier.citationAllergy and risk of childhood leukaemia: results from the UKCCS. 2007, 121 (4):819-24 Int. J. Canceren
dc.identifier.issn0020-7136-
dc.identifier.pmid17390373-
dc.identifier.doi10.1002/ijc.22702-
dc.identifier.urihttp://hdl.handle.net/10541/70177-
dc.description.abstractWe investigated the relationship between childhood leukaemia and preceding history of allergy. A nationwide case-control study of childhood cancers was conducted in the United Kingdom with population-based sampling of cases (n = 839) and controls (n = 1,337), matched on age, sex and region of residence. Information about clinically diagnosed allergies was obtained from primary care records. More than a third of subjects had at least one allergy diagnosed prior to leukaemia diagnosis (cases) or pseudo-diagnosis (controls). For both total acute lymphoblastic leukaemia (ALL) and common-ALL/precursor B-cell ALL (c-ALL), a history of eczema was associated with a 30% significant reduction in risk: the odds ratios (OR) and 95% confidence intervals (CI) were 0.70 (0.51-0.97) and 0.68 (0.48-0.98), respectively. Similar associations were observed for hayfever (OR = 0.47; 95% CI: 0.26-0.85 and OR = 0.62; 95% CI: 0.33-1.16 for ALL and c-ALL, respectively). No such patterns were seen either for asthma and ALL, or for any allergy and acute myeloid leukaemia. A comparative analysis of primary care records with parents recall of allergy revealed only moderate agreement with contemporaneous clinical diagnoses for both cases and controls--confirming the unreliability of parental report at interview. Our finding of a reciprocal relationship between allergy and ALL in children is compatible with the hypothesis that a dysregulated immune response is a critical determinant of childhood ALL.en
dc.language.isoenen
dc.subjectLeukaemiaen
dc.subject.meshAdolescent-
dc.subject.meshAsthma-
dc.subject.meshCase-Control Studies-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshEczema-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshHypersensitivity-
dc.subject.meshInterviews as Topic-
dc.subject.meshLeukemia-
dc.subject.meshMale-
dc.subject.meshMedical Records-
dc.subject.meshRhinitis, Allergic, Seasonal-
dc.subject.meshRisk Factors-
dc.titleAllergy and risk of childhood leukaemia: results from the UKCCS.en
dc.typeArticleen
dc.contributor.departmentEpidemiology and Genetics Unit, Department of Health Sciences, University of York, York, United Kingdom.en
dc.identifier.journalInternational Journal of Canceren

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