2.50
Hdl Handle:
http://hdl.handle.net/10541/70162
Title:
Origins of breast cancer subtypes and therapeutic implications.
Authors:
Sims, Andrew H; Howell, Anthony ( 0000-0002-3879-5991 ) ; Howell, Sacha J; Clarke, Robert B
Abstract:
This Review summarizes and evaluates the current evidence for the cellular origins of breast cancer subtypes identified by different approaches such as histology, molecular pathology, genetic and gene-expression analysis. Emerging knowledge of the normal breast cell types has led to the hypothesis that the subtypes of breast cancer might arise from mutations or genetic rearrangements occurring in different populations of stem cells and progenitor cells. We describe the common distinguishing features of these breast cancer subtypes and explain how these features relate both to prognosis and to selection of the most appropriate therapy. Recent data indicate that breast tumors may originate from cancer stem cells. Consequently, inhibition of stem-cell self-renewal pathways should be explored because of the likelihood that residual stem cells might be resistant to current therapies.
Affiliation:
Breast Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.
Citation:
Origins of breast cancer subtypes and therapeutic implications. 2007, 4 (9):516-25 Nat Clin Pract Oncol
Journal:
Nature Clinical Practice Oncology
Issue Date:
Sep-2007
URI:
http://hdl.handle.net/10541/70162
DOI:
10.1038/ncponc0908
PubMed ID:
17728710
Type:
Article
Language:
en
ISSN:
1743-4262
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorSims, Andrew H-
dc.contributor.authorHowell, Anthony-
dc.contributor.authorHowell, Sacha J-
dc.contributor.authorClarke, Robert B-
dc.date.accessioned2009-06-11T11:32:17Z-
dc.date.available2009-06-11T11:32:17Z-
dc.date.issued2007-09-
dc.identifier.citationOrigins of breast cancer subtypes and therapeutic implications. 2007, 4 (9):516-25 Nat Clin Pract Oncolen
dc.identifier.issn1743-4262-
dc.identifier.pmid17728710-
dc.identifier.doi10.1038/ncponc0908-
dc.identifier.urihttp://hdl.handle.net/10541/70162-
dc.description.abstractThis Review summarizes and evaluates the current evidence for the cellular origins of breast cancer subtypes identified by different approaches such as histology, molecular pathology, genetic and gene-expression analysis. Emerging knowledge of the normal breast cell types has led to the hypothesis that the subtypes of breast cancer might arise from mutations or genetic rearrangements occurring in different populations of stem cells and progenitor cells. We describe the common distinguishing features of these breast cancer subtypes and explain how these features relate both to prognosis and to selection of the most appropriate therapy. Recent data indicate that breast tumors may originate from cancer stem cells. Consequently, inhibition of stem-cell self-renewal pathways should be explored because of the likelihood that residual stem cells might be resistant to current therapies.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectTumour Markersen
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshFemale-
dc.subject.meshGene Expression Profiling-
dc.subject.meshHumans-
dc.subject.meshSelective Estrogen Receptor Modulators-
dc.subject.meshStem Cells-
dc.subject.meshTumor Markers, Biological-
dc.titleOrigins of breast cancer subtypes and therapeutic implications.en
dc.typeArticleen
dc.contributor.departmentBreast Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.en
dc.identifier.journalNature Clinical Practice Oncologyen

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