Affiliation
Breast Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.Issue Date
2007-09
Metadata
Show full item recordAbstract
This Review summarizes and evaluates the current evidence for the cellular origins of breast cancer subtypes identified by different approaches such as histology, molecular pathology, genetic and gene-expression analysis. Emerging knowledge of the normal breast cell types has led to the hypothesis that the subtypes of breast cancer might arise from mutations or genetic rearrangements occurring in different populations of stem cells and progenitor cells. We describe the common distinguishing features of these breast cancer subtypes and explain how these features relate both to prognosis and to selection of the most appropriate therapy. Recent data indicate that breast tumors may originate from cancer stem cells. Consequently, inhibition of stem-cell self-renewal pathways should be explored because of the likelihood that residual stem cells might be resistant to current therapies.Citation
Origins of breast cancer subtypes and therapeutic implications. 2007, 4 (9):516-25 Nat Clin Pract OncolJournal
Nature Clinical Practice OncologyDOI
10.1038/ncponc0908PubMed ID
17728710Type
ArticleLanguage
enISSN
1743-4262ae974a485f413a2113503eed53cd6c53
10.1038/ncponc0908