2.50
Hdl Handle:
http://hdl.handle.net/10541/70154
Title:
Defining growth hormone status in adults with hypopituitarism.
Authors:
Kaushal, K; Shalet, Stephen M
Abstract:
The identification of adults with severe growth hormone (GH) deficiency (GHD) is not straightforward. The insulin tolerance test remains the gold standard diagnostic test, although other stimuli such as GH-releasing hormone-arginine are gaining acceptance. Insulin-like growth factor-I has a poor diagnostic sensitivity in adult-onset GHD, but is more useful in the subgroup of adults with childhood-onset GHD. Therapeutic developments include increasing recognition of the need to continue GH therapy beyond final height in young adults with severe GHD on retesting. Consensus guidelines have provided a useful algorithm to identify individuals requiring retesting and the number of tests needed. The concept of partial GHD, recognized by paediatric endocrinologists for many years, is being examined in adults with hypothalamic-pituitary disease. Preliminary evidence suggests that this entity is associated with metabolic and anthropometric abnormalities intermediate between those in severe GHD and in healthy controls. It remains to be seen whether this subgroup will derive benefit from GH therapy. To date, therapeutic benefits of GH have been demonstrated only in adults with severe GHD. It is, therefore, imperative that these individuals are unequivocally identified; the diagnosis becomes more uncertain in the presence of obesity, increasing age, and in the absence of additional pituitary hormone deficits.
Affiliation:
Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Defining growth hormone status in adults with hypopituitarism. 2007, 68 (4):185-94 Horm. Res.
Journal:
Hormone Research
Issue Date:
2007
URI:
http://hdl.handle.net/10541/70154
DOI:
10.1159/000101286
PubMed ID:
17389809
Type:
Article
Language:
en
ISSN:
1423-0046
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorKaushal, K-
dc.contributor.authorShalet, Stephen M-
dc.date.accessioned2009-06-11T10:55:55Z-
dc.date.available2009-06-11T10:55:55Z-
dc.date.issued2007-
dc.identifier.citationDefining growth hormone status in adults with hypopituitarism. 2007, 68 (4):185-94 Horm. Res.en
dc.identifier.issn1423-0046-
dc.identifier.pmid17389809-
dc.identifier.doi10.1159/000101286-
dc.identifier.urihttp://hdl.handle.net/10541/70154-
dc.description.abstractThe identification of adults with severe growth hormone (GH) deficiency (GHD) is not straightforward. The insulin tolerance test remains the gold standard diagnostic test, although other stimuli such as GH-releasing hormone-arginine are gaining acceptance. Insulin-like growth factor-I has a poor diagnostic sensitivity in adult-onset GHD, but is more useful in the subgroup of adults with childhood-onset GHD. Therapeutic developments include increasing recognition of the need to continue GH therapy beyond final height in young adults with severe GHD on retesting. Consensus guidelines have provided a useful algorithm to identify individuals requiring retesting and the number of tests needed. The concept of partial GHD, recognized by paediatric endocrinologists for many years, is being examined in adults with hypothalamic-pituitary disease. Preliminary evidence suggests that this entity is associated with metabolic and anthropometric abnormalities intermediate between those in severe GHD and in healthy controls. It remains to be seen whether this subgroup will derive benefit from GH therapy. To date, therapeutic benefits of GH have been demonstrated only in adults with severe GHD. It is, therefore, imperative that these individuals are unequivocally identified; the diagnosis becomes more uncertain in the presence of obesity, increasing age, and in the absence of additional pituitary hormone deficits.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAge of Onset-
dc.subject.meshBody Height-
dc.subject.meshDiagnostic Techniques, Endocrine-
dc.subject.meshGrowth Disorders-
dc.subject.meshGrowth Hormone-
dc.subject.meshHumans-
dc.subject.meshHypopituitarism-
dc.subject.meshObesity-
dc.titleDefining growth hormone status in adults with hypopituitarism.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalHormone Researchen

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