Primary small cell malignant melanoma of the rectum: case report of a very rare tumor.

2.50
Hdl Handle:
http://hdl.handle.net/10541/70058
Title:
Primary small cell malignant melanoma of the rectum: case report of a very rare tumor.
Authors:
Wang, Guofeng; Eyden, Brian P; Yao, Li Fang; Chen, Shui Zhen; Banerjee, Saumitra S
Abstract:
Rectal/anorectal malignant melanomas are highly aggressive tumors with a poor prognosis and low 5-year survival rate. They are also very rare. Of the well-known histological variants of malignant melanoma, the small cell subtype is also very uncommon; consequently, small cell anorectal malignant melanoma is an exceedingly rare occurrence. In this article, the authors provide a detailed clinicopathological description of small cell malignant melanoma of the rectum, documenting clinical, histological, immunohistochemical, and ultrastructural features, to add to the sparse references on this tumor in the literature. The patient was a 53-year-old woman with a mass 2 cm from the anus, which was surgically removed. In histological sections, the tumor was a small cell malignant melanoma, with a tumor cell diameter of 7.6+/-1.0 microm, and a range of 5.5-10.7 microm (N = 100). Tumor cells were positive for S-100 protein and HMB-45 and contained sparse but unambiguous type II melanosomes. This article is one of the few detailed clinicopathological documentations of a small cell malignant melanoma of the rectum (anorectum) and the first to have the diagnosis confirmed ultrastructurally by the identification of melanosomes. The present case adds to the 3 mainly or entirely small cell anorectal malignant melanomas described in the literature. There are also at least 12 other cases with less well-defined numbers of small tumor cells or with small cells admixed with other cell morphologies. Documentation of these unusual morphological variants is important for identifying any distinctive outcome they might exhibit compared with conventional malignant melanoma.
Affiliation:
Department of Pathology, Second Affiliated Hospital to the Medical School of Zhejiang University, Hangzhou, China.
Citation:
Primary small cell malignant melanoma of the rectum: case report of a very rare tumor., 31 (4):315-20 Ultrastruct Pathol
Journal:
Ultrastructural Pathology
Issue Date:
2007
URI:
http://hdl.handle.net/10541/70058
DOI:
10.1080/01913120701465510
PubMed ID:
17786832
Type:
Article
Language:
en
ISSN:
1521-0758
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorWang, Guofeng-
dc.contributor.authorEyden, Brian P-
dc.contributor.authorYao, Li Fang-
dc.contributor.authorChen, Shui Zhen-
dc.contributor.authorBanerjee, Saumitra S-
dc.date.accessioned2009-06-09T16:46:13Z-
dc.date.available2009-06-09T16:46:13Z-
dc.date.issued2007-
dc.identifier.citationPrimary small cell malignant melanoma of the rectum: case report of a very rare tumor., 31 (4):315-20 Ultrastruct Patholen
dc.identifier.issn1521-0758-
dc.identifier.pmid17786832-
dc.identifier.doi10.1080/01913120701465510-
dc.identifier.urihttp://hdl.handle.net/10541/70058-
dc.description.abstractRectal/anorectal malignant melanomas are highly aggressive tumors with a poor prognosis and low 5-year survival rate. They are also very rare. Of the well-known histological variants of malignant melanoma, the small cell subtype is also very uncommon; consequently, small cell anorectal malignant melanoma is an exceedingly rare occurrence. In this article, the authors provide a detailed clinicopathological description of small cell malignant melanoma of the rectum, documenting clinical, histological, immunohistochemical, and ultrastructural features, to add to the sparse references on this tumor in the literature. The patient was a 53-year-old woman with a mass 2 cm from the anus, which was surgically removed. In histological sections, the tumor was a small cell malignant melanoma, with a tumor cell diameter of 7.6+/-1.0 microm, and a range of 5.5-10.7 microm (N = 100). Tumor cells were positive for S-100 protein and HMB-45 and contained sparse but unambiguous type II melanosomes. This article is one of the few detailed clinicopathological documentations of a small cell malignant melanoma of the rectum (anorectum) and the first to have the diagnosis confirmed ultrastructurally by the identification of melanosomes. The present case adds to the 3 mainly or entirely small cell anorectal malignant melanomas described in the literature. There are also at least 12 other cases with less well-defined numbers of small tumor cells or with small cells admixed with other cell morphologies. Documentation of these unusual morphological variants is important for identifying any distinctive outcome they might exhibit compared with conventional malignant melanoma.en
dc.language.isoenen
dc.subjectRectal Canceren
dc.subjectCancer Proteinsen
dc.subjectTumour Antigensen
dc.subject.meshAntigens, Neoplasm-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMelanoma-
dc.subject.meshMicroscopy, Electron, Transmission-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshRectal Neoplasms-
dc.titlePrimary small cell malignant melanoma of the rectum: case report of a very rare tumor.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Second Affiliated Hospital to the Medical School of Zhejiang University, Hangzhou, China.en
dc.identifier.journalUltrastructural Pathologyen
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