2.50
Hdl Handle:
http://hdl.handle.net/10541/70056
Title:
Estrogen deprivation for breast cancer prevention.
Authors:
Howell, Anthony ( 0000-0002-3879-5991 ) ; Clarke, Robert B; Evans, D Gareth R; Bundred, Nigel J; Cuzick, Jack; Santen, Richard J; Allred, D Craig
Abstract:
Estrogen deprivation (ED) either as a result of a natural or artificial menopause or the use of aromatase inhibitors in postmenopausal women results in a reduction of the incidence of breast cancer. Two major clinical trials of this approach comparing anastrozole or exemestane with placebo are currently in progress to test their efficacy for prevention. Reduction of contralateral breast lesions by at least 50% compared with tamoxifen indicate this approach has promise. The target lesion within the breast for ED is not known but we argue that hyperplastic enlarged lobular units (HELUs) as well as more advanced lesions are good candidates. A major problem for ED is de novo or acquired resistance to its effectiveness. We discuss potential mechanisms of resistance including high concentrations of tissue estrogens, increase in growth factor, and signal transduction pathways within the epithelial cell and activation of paracrine pathways from breast adipocytes, macrophages and fibroblasts. It may be possible to increase effectiveness of ED by additional preventive agents or by lifestyle alterations.
Affiliation:
CRUK Department of Medical Oncology, Christie Hospital, University of Manchester, UK.
Citation:
Estrogen deprivation for breast cancer prevention. 2007, 174:151-67 Recent Results Cancer Res.
Journal:
Recent results in cancer research.
Issue Date:
2007
URI:
http://hdl.handle.net/10541/70056
PubMed ID:
17302193
Type:
Article
Language:
en
ISSN:
0080-0015
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHowell, Anthony-
dc.contributor.authorClarke, Robert B-
dc.contributor.authorEvans, D Gareth R-
dc.contributor.authorBundred, Nigel J-
dc.contributor.authorCuzick, Jack-
dc.contributor.authorSanten, Richard J-
dc.contributor.authorAllred, D Craig-
dc.date.accessioned2009-06-09T16:28:55Z-
dc.date.available2009-06-09T16:28:55Z-
dc.date.issued2007-
dc.identifier.citationEstrogen deprivation for breast cancer prevention. 2007, 174:151-67 Recent Results Cancer Res.en
dc.identifier.issn0080-0015-
dc.identifier.pmid17302193-
dc.identifier.urihttp://hdl.handle.net/10541/70056-
dc.description.abstractEstrogen deprivation (ED) either as a result of a natural or artificial menopause or the use of aromatase inhibitors in postmenopausal women results in a reduction of the incidence of breast cancer. Two major clinical trials of this approach comparing anastrozole or exemestane with placebo are currently in progress to test their efficacy for prevention. Reduction of contralateral breast lesions by at least 50% compared with tamoxifen indicate this approach has promise. The target lesion within the breast for ED is not known but we argue that hyperplastic enlarged lobular units (HELUs) as well as more advanced lesions are good candidates. A major problem for ED is de novo or acquired resistance to its effectiveness. We discuss potential mechanisms of resistance including high concentrations of tissue estrogens, increase in growth factor, and signal transduction pathways within the epithelial cell and activation of paracrine pathways from breast adipocytes, macrophages and fibroblasts. It may be possible to increase effectiveness of ED by additional preventive agents or by lifestyle alterations.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshAnimals-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshClinical Trials as Topic-
dc.subject.meshEpithelial Cells-
dc.subject.meshEstrogen Antagonists-
dc.subject.meshEstrogens-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMenopause-
dc.titleEstrogen deprivation for breast cancer prevention.en
dc.typeArticleen
dc.contributor.departmentCRUK Department of Medical Oncology, Christie Hospital, University of Manchester, UK.en
dc.identifier.journalRecent results in cancer research.en

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