2.50
Hdl Handle:
http://hdl.handle.net/10541/70048
Title:
High accuracy multiple scatter modelling for 3D whole body PET.
Authors:
Markiewicz, P J; Tamal, M; Julyan, Peter J; Hastings, David L; Reader, Andrew J
Abstract:
A new technique for modelling multiple-order Compton scatter which uses the absolute probabilities relating the image space to the projection space in 3D whole body PET is presented. The details considered in this work give a valuable insight into the scatter problem, particularly for multiple scatter. Such modelling is advantageous for large attenuating media where scatter is a dominant component of the measured data, and where multiple scatter may dominate the total scatter depending on the energy threshold and object size. The model offers distinct features setting it apart from previous research: (1) specification of the scatter distribution for each voxel based on the transmission data, the physics of Compton scattering and the specification of a given PET system; (2) independence from the true activity distribution; (3) in principle no scaling or iterative process is required to find the distribution; (4) explicit multiple scatter modelling; (5) no scatter subtraction or addition to the forward model when included in the system matrix used with statistical image reconstruction methods; (6) adaptability to many different scatter compensation methods from simple and fast to more sophisticated and therefore slower methods; (7) accuracy equivalent to that of a Monte Carlo model. The scatter model has been validated using Monte Carlo simulation (SimSET).
Affiliation:
School of Chemical Engineering and Analytical Science, The University of Manchester, Faraday Building, Sackville Street, Manchester M60 1QD, UK. p.markiewicz@postgrad.manchester.ac.uk
Citation:
High accuracy multiple scatter modelling for 3D whole body PET. 2007, 52 (3):829-47 Phys Med Biol
Journal:
Physics in Medicine and Biology
Issue Date:
7-Feb-2007
URI:
http://hdl.handle.net/10541/70048
DOI:
10.1088/0031-9155/52/3/021
PubMed ID:
17228124
Type:
Article
Language:
en
ISSN:
0031-9155
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMarkiewicz, P J-
dc.contributor.authorTamal, M-
dc.contributor.authorJulyan, Peter J-
dc.contributor.authorHastings, David L-
dc.contributor.authorReader, Andrew J-
dc.date.accessioned2009-06-09T16:56:41Z-
dc.date.available2009-06-09T16:56:41Z-
dc.date.issued2007-02-07-
dc.identifier.citationHigh accuracy multiple scatter modelling for 3D whole body PET. 2007, 52 (3):829-47 Phys Med Biolen
dc.identifier.issn0031-9155-
dc.identifier.pmid17228124-
dc.identifier.doi10.1088/0031-9155/52/3/021-
dc.identifier.urihttp://hdl.handle.net/10541/70048-
dc.description.abstractA new technique for modelling multiple-order Compton scatter which uses the absolute probabilities relating the image space to the projection space in 3D whole body PET is presented. The details considered in this work give a valuable insight into the scatter problem, particularly for multiple scatter. Such modelling is advantageous for large attenuating media where scatter is a dominant component of the measured data, and where multiple scatter may dominate the total scatter depending on the energy threshold and object size. The model offers distinct features setting it apart from previous research: (1) specification of the scatter distribution for each voxel based on the transmission data, the physics of Compton scattering and the specification of a given PET system; (2) independence from the true activity distribution; (3) in principle no scaling or iterative process is required to find the distribution; (4) explicit multiple scatter modelling; (5) no scatter subtraction or addition to the forward model when included in the system matrix used with statistical image reconstruction methods; (6) adaptability to many different scatter compensation methods from simple and fast to more sophisticated and therefore slower methods; (7) accuracy equivalent to that of a Monte Carlo model. The scatter model has been validated using Monte Carlo simulation (SimSET).en
dc.language.isoenen
dc.subject.meshAlgorithms-
dc.subject.meshBiophysical Phenomena-
dc.subject.meshBiophysics-
dc.subject.meshHumans-
dc.subject.meshImaging, Three-Dimensional-
dc.subject.meshModels, Theoretical-
dc.subject.meshMonte Carlo Method-
dc.subject.meshPhotons-
dc.subject.meshPositron-Emission Tomography-
dc.subject.meshScattering, Radiation-
dc.titleHigh accuracy multiple scatter modelling for 3D whole body PET.en
dc.typeArticleen
dc.contributor.departmentSchool of Chemical Engineering and Analytical Science, The University of Manchester, Faraday Building, Sackville Street, Manchester M60 1QD, UK. p.markiewicz@postgrad.manchester.ac.uken
dc.identifier.journalPhysics in Medicine and Biologyen

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