Pulmonary lipomatous hemangiopericytoma: report of a rare tumor and comparison with solitary fibrous tumor.

2.50
Hdl Handle:
http://hdl.handle.net/10541/70045
Title:
Pulmonary lipomatous hemangiopericytoma: report of a rare tumor and comparison with solitary fibrous tumor.
Authors:
Yamazaki, Kazuto; Eyden, Brian P
Abstract:
Lipomatous hemangiopericytoma is a rare mesenchymal tumor showing areas of lipid-containing cells admixed with a spindle-cell component. Like other hemangiopericytomas, it shows a similar vascular pattern to solitary fibrous tumor and, partly for this reason, it and other hemangiopericytomas have been subsumed into solitary fibrous tumor. The present study provides a comprehensive documentation of a single case of pulmonary lipomatous hemangiopericytoma of the lung, the first to be described at this site, and compares it with solitary fibrous tumor, in terms of clinical, histological, immunohistochemical, ultrastructural, and cytogenetic findings. Apart from the lipid-laden-cell component, pulmonary lipomatous hemangiopericytoma and solitary fibrous tumor were similar histologically. Bcl-2 was positive in both. CD34 was minimally expressed in pulmonary lipomatous hemangiopericytoma, which possessed some non-descriptive intercellular junctions, a feature shared by solitary fibrous tumor, which was CD34 positive. However, one of the latter was rich in gap junctions, a feature consistent with strong connexin (Cx) 43 staining and the existence, hitherto unappreciated, of a CD34/Cx43-positive tumor cell network. In pulmonary lipomatous hemangiopericytoma, chromosomal deletions of 43-44, X, -Y were found. In solitary fibrous tumor, 46, XY, del(13)(q?) abnormalities and abnormalities involving chromosome 10 were frequently observed. These similarities and differences are discussed in the context of the currently favored diagnostic fusion of hemangiopericytoma and solitary fibrous tumor.
Affiliation:
Department of Pathology, Saiseikai Central Hospital, Tokyo, Japan. KazutoYamazaki@aol.com
Citation:
Pulmonary lipomatous hemangiopericytoma: report of a rare tumor and comparison with solitary fibrous tumor., 31 (1):51-61 Ultrastruct Pathol
Journal:
Ultrastructural Pathology
Issue Date:
2007
URI:
http://hdl.handle.net/10541/70045
DOI:
10.1080/01913120601172067
PubMed ID:
17455098
Type:
Article
Language:
en
ISSN:
1521-0758
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorYamazaki, Kazuto-
dc.contributor.authorEyden, Brian P-
dc.date.accessioned2009-06-09T16:49:01Z-
dc.date.available2009-06-09T16:49:01Z-
dc.date.issued2007-
dc.identifier.citationPulmonary lipomatous hemangiopericytoma: report of a rare tumor and comparison with solitary fibrous tumor., 31 (1):51-61 Ultrastruct Patholen
dc.identifier.issn1521-0758-
dc.identifier.pmid17455098-
dc.identifier.doi10.1080/01913120601172067-
dc.identifier.urihttp://hdl.handle.net/10541/70045-
dc.description.abstractLipomatous hemangiopericytoma is a rare mesenchymal tumor showing areas of lipid-containing cells admixed with a spindle-cell component. Like other hemangiopericytomas, it shows a similar vascular pattern to solitary fibrous tumor and, partly for this reason, it and other hemangiopericytomas have been subsumed into solitary fibrous tumor. The present study provides a comprehensive documentation of a single case of pulmonary lipomatous hemangiopericytoma of the lung, the first to be described at this site, and compares it with solitary fibrous tumor, in terms of clinical, histological, immunohistochemical, ultrastructural, and cytogenetic findings. Apart from the lipid-laden-cell component, pulmonary lipomatous hemangiopericytoma and solitary fibrous tumor were similar histologically. Bcl-2 was positive in both. CD34 was minimally expressed in pulmonary lipomatous hemangiopericytoma, which possessed some non-descriptive intercellular junctions, a feature shared by solitary fibrous tumor, which was CD34 positive. However, one of the latter was rich in gap junctions, a feature consistent with strong connexin (Cx) 43 staining and the existence, hitherto unappreciated, of a CD34/Cx43-positive tumor cell network. In pulmonary lipomatous hemangiopericytoma, chromosomal deletions of 43-44, X, -Y were found. In solitary fibrous tumor, 46, XY, del(13)(q?) abnormalities and abnormalities involving chromosome 10 were frequently observed. These similarities and differences are discussed in the context of the currently favored diagnostic fusion of hemangiopericytoma and solitary fibrous tumor.en
dc.language.isoenen
dc.subjectLung Canceren
dc.subjectFibrous Tumoursen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAntigens, CD34-
dc.subject.meshChromosome Aberrations-
dc.subject.meshConnexin 43-
dc.subject.meshCytogenetic Analysis-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshFemale-
dc.subject.meshHemangiopericytoma-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshLipoma-
dc.subject.meshLung Neoplasms-
dc.subject.meshMale-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms, Fibrous Tissue-
dc.subject.meshProto-Oncogene Proteins c-bcl-2-
dc.titlePulmonary lipomatous hemangiopericytoma: report of a rare tumor and comparison with solitary fibrous tumor.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Saiseikai Central Hospital, Tokyo, Japan. KazutoYamazaki@aol.comen
dc.identifier.journalUltrastructural Pathologyen

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