Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study.

2.50
Hdl Handle:
http://hdl.handle.net/10541/70039
Title:
Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study.
Authors:
Völzke, Henry; Friedrich, Nele; Schipf, Sabine; Haring, Robin; Lüdemann, Jan; Nauck, Matthias; Dörr, Marcus; Brabant, Georg E; Wallaschofski, Henri
Abstract:
OBJECTIVE: There is current debate on whether serum IGF-I levels are associated with thyroid disorders. The aims of the present study were: 1) to investigate possible associations between serum IGF-I levels and thyroid disorders and 2) to analyze the role of serum IGF binding protein (IGFBP)-3 and TSH levels for these associations. DESIGN: This was a cross-sectional Study of Health in Pomerania. SETTING: The study was conducted in the general population of northeast Germany. Subjects: The study population comprised 3662 subjects (1746 women) without history of thyroid disorders. INTERVENTIONS: No interventions have been performed. MAIN OUTCOME MEASURES: Goiter and thyroid nodules were determined by ultrasound. Serum TSH levels less than 0.25 mIU/liter were considered decreased. RESULTS: Adjusted for major confounders and risk factors for thyroid disorders, subjects with serum IGF-I levels above the upper tertile had higher odds for goiter relative to subjects with serum IGF-I levels below the lower tertile [odds ratio (OR) 1.67; 95% confidence interval (CI) 1.24-2.26 in women; OR 2.04; 95% CI 1.55-2.68 in men]. A similar association was present for thyroid nodules in men (OR 1.64; 95% CI 1.17-2.32) and for decreased serum TSH levels in women (OR 1.65; 95% CI 1.00-2.69). Serum IGFBP-3 levels were not associated with thyroid disorders and did not represent effect modifiers for the association between serum IGF-I levels and the endpoints. CONCLUSIONS: We conclude that high serum IGF-I levels are associated with goiter. Whereas high serum IGF-I levels are also related to thyroid nodules in men, they are related to decreased serum TSH levels in women. Serum IGFBP-3 and TSH levels did not modulate these associations.
Affiliation:
Institute of Community Medicine, University of Greifswald, D-17487 Greifswald, Germany. voelzke@uni-greifswald.de
Citation:
Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study. 2007, 92 (10):4039-45 J. Clin. Endocrinol. Metab.
Journal:
The Journal of Clinical Endocrinology and Metabolism
Issue Date:
Oct-2007
URI:
http://hdl.handle.net/10541/70039
DOI:
10.1210/jc.2007-0816
PubMed ID:
17666480
Type:
Article
Language:
en
ISSN:
0021-972X
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorVölzke, Henry-
dc.contributor.authorFriedrich, Nele-
dc.contributor.authorSchipf, Sabine-
dc.contributor.authorHaring, Robin-
dc.contributor.authorLüdemann, Jan-
dc.contributor.authorNauck, Matthias-
dc.contributor.authorDörr, Marcus-
dc.contributor.authorBrabant, Georg E-
dc.contributor.authorWallaschofski, Henri-
dc.date.accessioned2009-06-09T16:38:48Z-
dc.date.available2009-06-09T16:38:48Z-
dc.date.issued2007-10-
dc.identifier.citationAssociation between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study. 2007, 92 (10):4039-45 J. Clin. Endocrinol. Metab.en
dc.identifier.issn0021-972X-
dc.identifier.pmid17666480-
dc.identifier.doi10.1210/jc.2007-0816-
dc.identifier.urihttp://hdl.handle.net/10541/70039-
dc.description.abstractOBJECTIVE: There is current debate on whether serum IGF-I levels are associated with thyroid disorders. The aims of the present study were: 1) to investigate possible associations between serum IGF-I levels and thyroid disorders and 2) to analyze the role of serum IGF binding protein (IGFBP)-3 and TSH levels for these associations. DESIGN: This was a cross-sectional Study of Health in Pomerania. SETTING: The study was conducted in the general population of northeast Germany. Subjects: The study population comprised 3662 subjects (1746 women) without history of thyroid disorders. INTERVENTIONS: No interventions have been performed. MAIN OUTCOME MEASURES: Goiter and thyroid nodules were determined by ultrasound. Serum TSH levels less than 0.25 mIU/liter were considered decreased. RESULTS: Adjusted for major confounders and risk factors for thyroid disorders, subjects with serum IGF-I levels above the upper tertile had higher odds for goiter relative to subjects with serum IGF-I levels below the lower tertile [odds ratio (OR) 1.67; 95% confidence interval (CI) 1.24-2.26 in women; OR 2.04; 95% CI 1.55-2.68 in men]. A similar association was present for thyroid nodules in men (OR 1.64; 95% CI 1.17-2.32) and for decreased serum TSH levels in women (OR 1.65; 95% CI 1.00-2.69). Serum IGFBP-3 levels were not associated with thyroid disorders and did not represent effect modifiers for the association between serum IGF-I levels and the endpoints. CONCLUSIONS: We conclude that high serum IGF-I levels are associated with goiter. Whereas high serum IGF-I levels are also related to thyroid nodules in men, they are related to decreased serum TSH levels in women. Serum IGFBP-3 and TSH levels did not modulate these associations.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCross-Sectional Studies-
dc.subject.meshFemale-
dc.subject.meshGermany-
dc.subject.meshGoiter-
dc.subject.meshHumans-
dc.subject.meshInsulin-Like Growth Factor Binding Proteins-
dc.subject.meshInsulin-Like Growth Factor I-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshRisk Factors-
dc.subject.meshSex Distribution-
dc.subject.meshThyroid Nodule-
dc.subject.meshThyrotropin-
dc.titleAssociation between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study.en
dc.typeArticleen
dc.contributor.departmentInstitute of Community Medicine, University of Greifswald, D-17487 Greifswald, Germany. voelzke@uni-greifswald.deen
dc.identifier.journalThe Journal of Clinical Endocrinology and Metabolismen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.