Failure of antibody response to polysaccharide antigen in treated panhypopituitary adults.

2.50
Hdl Handle:
http://hdl.handle.net/10541/69761
Title:
Failure of antibody response to polysaccharide antigen in treated panhypopituitary adults.
Authors:
Mukherjee, Annice; Helbert, M; Ryder, W David J; Borrow, R; Davis, Julian R E; Shalet, Stephen M
Abstract:
Although pituitary hormones are known to affect immune function, treated hypopituitarism is not a recognized cause of immune deficiency in humans. We set out to assess integrity of baseline and stimulated immune function in severely hypopituitary adults. Twenty-one panhypopituitary adults (group 1), on stable pituitary replacement including growth hormone, and 12 healthy volunteers (group 2) were studied. Lymphocyte subsets, pneumococcal antibody levels pre- and 1 month after polysaccharide vaccination, T cell numbers and in-vitro interferon (IFN)-gamma response were studied. There were no significant differences in T cell numbers or IFN-gamma secretion. B cell numbers were lower in group 1, especially those with low prolactin levels. Independent of this finding, nine of 21 patients in this group had low antibody response to polysaccharide antigen. This was most striking in those with low insulin-like growth factor 1 levels and appeared to be independent of the use of anti-convulsants or corticosteroid replacement. Significant humoral immune deficiency is seen in panhypopituitarism and may contribute to morbidity.
Affiliation:
Department of Endocrinology, Christie Hospital, Manchester, UK. annice.mukherjee@srht.nhs.uk
Citation:
Failure of antibody response to polysaccharide antigen in treated panhypopituitary adults. 2009, 156 (2):271-7 Clin. Exp. Immunol.
Journal:
Clinical and Experimental Immunology
Issue Date:
May-2009
URI:
http://hdl.handle.net/10541/69761
DOI:
10.1111/j.1365-2249.2009.03881.x
PubMed ID:
19236430
Type:
Article
Language:
en
ISSN:
1365-2249
Appears in Collections:
All Christie Publications ; Endocrinology

Full metadata record

DC FieldValue Language
dc.contributor.authorMukherjee, Annice-
dc.contributor.authorHelbert, M-
dc.contributor.authorRyder, W David J-
dc.contributor.authorBorrow, R-
dc.contributor.authorDavis, Julian R E-
dc.contributor.authorShalet, Stephen M-
dc.date.accessioned2009-06-05T10:11:06Z-
dc.date.available2009-06-05T10:11:06Z-
dc.date.issued2009-05-
dc.identifier.citationFailure of antibody response to polysaccharide antigen in treated panhypopituitary adults. 2009, 156 (2):271-7 Clin. Exp. Immunol.en
dc.identifier.issn1365-2249-
dc.identifier.pmid19236430-
dc.identifier.doi10.1111/j.1365-2249.2009.03881.x-
dc.identifier.urihttp://hdl.handle.net/10541/69761-
dc.description.abstractAlthough pituitary hormones are known to affect immune function, treated hypopituitarism is not a recognized cause of immune deficiency in humans. We set out to assess integrity of baseline and stimulated immune function in severely hypopituitary adults. Twenty-one panhypopituitary adults (group 1), on stable pituitary replacement including growth hormone, and 12 healthy volunteers (group 2) were studied. Lymphocyte subsets, pneumococcal antibody levels pre- and 1 month after polysaccharide vaccination, T cell numbers and in-vitro interferon (IFN)-gamma response were studied. There were no significant differences in T cell numbers or IFN-gamma secretion. B cell numbers were lower in group 1, especially those with low prolactin levels. Independent of this finding, nine of 21 patients in this group had low antibody response to polysaccharide antigen. This was most striking in those with low insulin-like growth factor 1 levels and appeared to be independent of the use of anti-convulsants or corticosteroid replacement. Significant humoral immune deficiency is seen in panhypopituitarism and may contribute to morbidity.en
dc.language.isoenen
dc.subjectAutoimmunityen
dc.subjectHypopituitarismen
dc.subjectImmune Functionen
dc.subjectProlactin Deficiencyen
dc.titleFailure of antibody response to polysaccharide antigen in treated panhypopituitary adults.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Manchester, UK. annice.mukherjee@srht.nhs.uken
dc.identifier.journalClinical and Experimental Immunologyen

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