The impact of radiotherapy late effects on quality of life in gynaecological cancer patients.

2.50
Hdl Handle:
http://hdl.handle.net/10541/69601
Title:
The impact of radiotherapy late effects on quality of life in gynaecological cancer patients.
Authors:
Barker, Claire L; Routledge, Jacqueline A; Farnell, Damian J J; Swindell, Ric; Davidson, Susan E
Abstract:
The aims of this study were to assess changes in quality of life (QoL) scores in relation to radical radiotherapy for gynaecological cancer (before and after treatment up to 3 years), and to identify the effect that late treatment effects have on QoL. This was a prospective study involving 225 gynaecological cancer patients. A QoL instrument (European Organisation for the Research and Treatment of Cancer QLQ-C30) and late treatment effect questionnaire (Late Effects Normal Tissues - Subjective Objective Management Analysis) were completed before and after treatment (immediately after radiotherapy, 6 weeks, 12, 24 and 36 months after treatment). Most patients had acute physical symptoms and impaired functioning immediately after treatment. Levels of fatigue and diarrhoea only returned to those at pre-treatment assessment after 6 weeks. Patients with high treatment toxicity scores had lower global QoL scores. In conclusion, treatment with radiotherapy for gynaecological cancer has a negative effect on QoL, most apparent immediately after treatment. Certain late treatment effects have a negative effect on QoL for at least 2 years after radiotherapy. These treatment effects are centred on symptoms relating to the rectum and bowel, for example, diarrhoea, tenesmus and urgency. Future research will identify specific symptoms resulting from late treatment toxicity that have the greatest effect on QoL; therefore allowing effective management plans to be developed to reduce these symptoms and improve QoL in gynaecological cancer patients.
Affiliation:
Department of Clinical Oncology, the Christie NHS Foundation Trust, Manchester, UK. claire.barker@doctors.org.uk
Citation:
The impact of radiotherapy late effects on quality of life in gynaecological cancer patients. 2009, 100 (10):1558-65 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
19-May-2009
URI:
http://hdl.handle.net/10541/69601
DOI:
10.1038/sj.bjc.6605050
PubMed ID:
19384297
Type:
Article
Language:
en
ISSN:
1532-1827
Appears in Collections:
All Christie Publications ; Clinical Oncology

Full metadata record

DC FieldValue Language
dc.contributor.authorBarker, Claire L-
dc.contributor.authorRoutledge, Jacqueline A-
dc.contributor.authorFarnell, Damian J J-
dc.contributor.authorSwindell, Ric-
dc.contributor.authorDavidson, Susan E-
dc.date.accessioned2009-06-02T14:25:50Z-
dc.date.available2009-06-02T14:25:50Z-
dc.date.issued2009-05-19-
dc.identifier.citationThe impact of radiotherapy late effects on quality of life in gynaecological cancer patients. 2009, 100 (10):1558-65 Br. J. Canceren
dc.identifier.issn1532-1827-
dc.identifier.pmid19384297-
dc.identifier.doi10.1038/sj.bjc.6605050-
dc.identifier.urihttp://hdl.handle.net/10541/69601-
dc.description.abstractThe aims of this study were to assess changes in quality of life (QoL) scores in relation to radical radiotherapy for gynaecological cancer (before and after treatment up to 3 years), and to identify the effect that late treatment effects have on QoL. This was a prospective study involving 225 gynaecological cancer patients. A QoL instrument (European Organisation for the Research and Treatment of Cancer QLQ-C30) and late treatment effect questionnaire (Late Effects Normal Tissues - Subjective Objective Management Analysis) were completed before and after treatment (immediately after radiotherapy, 6 weeks, 12, 24 and 36 months after treatment). Most patients had acute physical symptoms and impaired functioning immediately after treatment. Levels of fatigue and diarrhoea only returned to those at pre-treatment assessment after 6 weeks. Patients with high treatment toxicity scores had lower global QoL scores. In conclusion, treatment with radiotherapy for gynaecological cancer has a negative effect on QoL, most apparent immediately after treatment. Certain late treatment effects have a negative effect on QoL for at least 2 years after radiotherapy. These treatment effects are centred on symptoms relating to the rectum and bowel, for example, diarrhoea, tenesmus and urgency. Future research will identify specific symptoms resulting from late treatment toxicity that have the greatest effect on QoL; therefore allowing effective management plans to be developed to reduce these symptoms and improve QoL in gynaecological cancer patients.en
dc.language.isoenen
dc.subjectRadiotherapyen
dc.subjectLate Toxicityen
dc.subjectQuality of Lifeen
dc.subjectGynaecological Canceren
dc.subjectLongitudinal Studyen
dc.titleThe impact of radiotherapy late effects on quality of life in gynaecological cancer patients.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, the Christie NHS Foundation Trust, Manchester, UK. claire.barker@doctors.org.uken
dc.identifier.journalBritish Journal of Canceren

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