2.50
Hdl Handle:
http://hdl.handle.net/10541/69556
Title:
Risk reducing mastectomy: outcomes in 10 European centres.
Authors:
Evans, D Gareth R; Baildam, Andrew D; Anderson, Elizabeth; Brain, Anne; Shenton, Andrew; Vasen, H F A; Eccles, Diana; Lucassen, A; Pichert, G; Hamed, H; Moller, P; Maehle, Lovise; Morrison, P J; Stoppa-Lyonnet, D; Gregory, H; Smyth, E; Niederacher, Dieter; Nestle-Krämling, C; Campbell, J; Hopwood, Penelope; Lalloo, Fiona; Howell, Anthony ( 0000-0002-3879-5991 )
Abstract:
BACKGROUND: Increasingly women at high risk of breast cancer are opting for risk reducing surgery. The aim of this study was to assess the effectiveness of this approach in women at high risk in both carriers and non-carriers of BRCA1/2. METHODS: Data from 10 European centres that offer a genetic counselling and screening service to women at risk were obtained prospectively from 1995. Breast cancer risks were estimated from life tables and a control group of women at risk who did not undergo surgery. RESULTS: The combined centres have data on 550 women who have undergone risk reducing mastectomy with greater than 3334 women years of follow-up. Operations were carried out on women with lifetime risks of 25-80%, with an average expected incidence rate of 1% per year. No breast cancers have occurred in this cohort in the "at risk" unaffected breast, whereas >34 would have been expected. A high rate (2-3.6%) of occult disease was identified in the at risk breast at the time of surgery. INTERPRETATION: We conclude that risk reducing surgery is highly effective.
Affiliation:
Central Manchester and Manchester Children's University Hospitals NHS Trust, St Mary's Hospital, Manchester, M13 0JH, UK. gareth.evans@cmmc.nhs.uk
Citation:
Risk reducing mastectomy: outcomes in 10 European centres. 2009, 46 (4):254-8 J. Med. Genet.
Journal:
Journal of Medical Genetics
Issue Date:
Apr-2009
URI:
http://hdl.handle.net/10541/69556
DOI:
10.1136/jmg.2008.062232
PubMed ID:
18996907
Type:
Article
Language:
en
ISSN:
1468-6244
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEvans, D Gareth R-
dc.contributor.authorBaildam, Andrew D-
dc.contributor.authorAnderson, Elizabeth-
dc.contributor.authorBrain, Anne-
dc.contributor.authorShenton, Andrew-
dc.contributor.authorVasen, H F A-
dc.contributor.authorEccles, Diana-
dc.contributor.authorLucassen, A-
dc.contributor.authorPichert, G-
dc.contributor.authorHamed, H-
dc.contributor.authorMoller, P-
dc.contributor.authorMaehle, Lovise-
dc.contributor.authorMorrison, P J-
dc.contributor.authorStoppa-Lyonnet, D-
dc.contributor.authorGregory, H-
dc.contributor.authorSmyth, E-
dc.contributor.authorNiederacher, Dieter-
dc.contributor.authorNestle-Krämling, C-
dc.contributor.authorCampbell, J-
dc.contributor.authorHopwood, Penelope-
dc.contributor.authorLalloo, Fiona-
dc.contributor.authorHowell, Anthony-
dc.date.accessioned2009-06-02T11:56:31Z-
dc.date.available2009-06-02T11:56:31Z-
dc.date.issued2009-04-
dc.identifier.citationRisk reducing mastectomy: outcomes in 10 European centres. 2009, 46 (4):254-8 J. Med. Genet.en
dc.identifier.issn1468-6244-
dc.identifier.pmid18996907-
dc.identifier.doi10.1136/jmg.2008.062232-
dc.identifier.urihttp://hdl.handle.net/10541/69556-
dc.description.abstractBACKGROUND: Increasingly women at high risk of breast cancer are opting for risk reducing surgery. The aim of this study was to assess the effectiveness of this approach in women at high risk in both carriers and non-carriers of BRCA1/2. METHODS: Data from 10 European centres that offer a genetic counselling and screening service to women at risk were obtained prospectively from 1995. Breast cancer risks were estimated from life tables and a control group of women at risk who did not undergo surgery. RESULTS: The combined centres have data on 550 women who have undergone risk reducing mastectomy with greater than 3334 women years of follow-up. Operations were carried out on women with lifetime risks of 25-80%, with an average expected incidence rate of 1% per year. No breast cancers have occurred in this cohort in the "at risk" unaffected breast, whereas >34 would have been expected. A high rate (2-3.6%) of occult disease was identified in the at risk breast at the time of surgery. INTERPRETATION: We conclude that risk reducing surgery is highly effective.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBRCA1 Protein-
dc.subject.meshBRCA2 Protein-
dc.subject.meshBreast Neoplasms-
dc.subject.meshEurope-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshGenetic Counseling-
dc.subject.meshGenetic Screening-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshMastectomy-
dc.subject.meshMiddle Aged-
dc.subject.meshOvariectomy-
dc.subject.meshRisk Factors-
dc.subject.meshYoung Adult-
dc.titleRisk reducing mastectomy: outcomes in 10 European centres.en
dc.typeArticleen
dc.contributor.departmentCentral Manchester and Manchester Children's University Hospitals NHS Trust, St Mary's Hospital, Manchester, M13 0JH, UK. gareth.evans@cmmc.nhs.uken
dc.identifier.journalJournal of Medical Geneticsen

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